Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O15127 | SCAMP2 | Secretory carrier-associated membrane protein 2 … | Homo sapiens (Human) | 329 aa |
Protein Details: O15127 (SCAMP2)
Protein Information
| Accession | O15127 |
|---|---|
| Protein Names | Secretory carrier-associated membrane protein 2 (Secretory carrier membrane protein 2) |
| Gene Symbol | SCAMP2 |
| Organism | Homo sapiens (Human) |
| Length | 329 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 24357059 25914232 26111759 29733200 31251020 31382980 32651440 33636221 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSAFDTNPFA11DPVDVNPFQD21PSVTQLTNAP31QGGLAEFNPF41SETNAATTVP
51-10051VTQLPGSSQP61AVLQPSVEPT71QPTPQAVVSA81AQAGLLRQQE91ELDRKAAELE
101-150101RKERELQNTV111ANLHVRQNNW121PPLPSWCPVK131PCFYQDFSTE141IPADYQRICK
151-200151MLYYLWMLHS161VTLFLNLLAC171LAWFSGNSSK181GVDFGLSILW191FLIFTPCAFL
201-250201CWYRPIYKAF211RSDNSFSFFV221FFFVFFCQIG231IYIIQLVGIP241GLGDSGWIAA
251-300251LSTLDNHSLA261ISVIMMVVAG271FFTLCAVLSV281FLLQRVHSLY291RRTGASFQQA
301-329301QEEFSQGIFS311SRTFHRAASS321AAQGAFQGN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 127 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.70
Deep-Palm: 0.40
|
|
| 132 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.78
Deep-Palm: 0.65
|
|
| 149 | - | - | - |
Deep-Palm: 0.08
|
|
| 170 | - | - | - |
Deep-Palm: 0.67
|
|
| 197 | SWISSPALM DBPTM CYSMODDB | SCAMP family | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.66
|
| 201 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.39
|
|
| 227 | - | - | - |
Deep-Palm: 0.05
|
|
| 275 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.82
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
9
Jurkat T cell
Specificity: 0.333
9/9 (100.0%)
4
LNCaP
Specificity: 0.148
4/4 (100.0%)
4
Primary T cell
Specificity: 0.148
4/4 (100.0%)
3
CEM 174 cell
Specificity: 0.111
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.074
2/2 (100.0%)
1
U937 cell
Specificity: 0.037
1/1 (100.0%)
1
293T cell
Specificity: 0.037
1/1 (100.0%)
1
heart
Specificity: 0.037
1/1 (100.0%)
1
HUVECs
Specificity: 0.037
1/1 (100.0%)
1
DU145 cell
Specificity: 0.037
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 207 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 215 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 227 | C → Lfs*30 | 0.002288 | INS | Frame Shift Ins | STAD |
| 227 | C → Vfs*3 | 0.003774 | DEL | Frame Shift Del | UCEC |
| 227 | C → Lfs*30 | 0.001887 | INS | Frame Shift Ins | UCEC |