Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O15143 | ARPC1B | Actin-related protein 2/3 complex subunit … | Homo sapiens (Human) | 372 aa |
Protein Details: O15143 (ARPC1B)
Protein Information
| Accession | O15143 |
|---|---|
| Protein Names | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) |
| Gene Symbol | ARPC1B |
| Organism | Homo sapiens (Human) |
| Length | 372 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 31382980 36430497 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAYHSFLVEP11ISCHAWNKDR21TQIAICPNNH31EVHIYEKSGA41KWTKVHELKE
51-10051HNGQVTGIDW61APESNRIVTC71GTDRNAYVWT81LKGRTWKPTL91VILRINRAAR
101-150101CVRWAPNENK111FAVGSGSRVI121SICYFEQEND131WWVCKHIKKP141IRSTVLSLDW
151-200151HPNNVLLAAG161SCDFKCRIFS171AYIKEVEERP181APTPWGSKMP191FGELMFESSS
201-250201SCGWVHGVCF211SASGSRVAWV221SHDSTVCLAD231ADKKMAVATL241ASETLPLLAL
251-300251TFITDNSLVA261AGHDCFPVLF271TYDAAAGMLS281FGGRLDVPKQ291SSQRGLTARE
301-350301RFQNLDKKAS311SEGGTAAGAG321LDSLHKNSVS331QISVLSGGKA341KCSQFCTTGM
351-372351DGGMSIWDVK361SLESALKDLK371IK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 13 | WD40/YVTN repeat-like-containing domain superfamily Actin-related protein 2/3 complex subunit 1 | - |
Unknown
(32651440)
|
Deep-Palm: 0.03
|
|
| 26 | WD40/YVTN repeat-like-containing domain superfamily Actin-related protein 2/3 complex subunit 1 WD40-repeat-containing domain superfamily | - | - |
Deep-Palm: 0.30
|
|
| 70 | - | - | - |
Deep-Palm: 0.71
|
|
| 101 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.94
|
|
| 123 | - | - | - |
Deep-Palm: 0.11
|
|
| 134 | - | - | - |
Deep-Palm: 0.16
|
|
| 162 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.83
Deep-Palm: 0.39
|
|
| 166 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.72
|
|
| 202 | - | - | - |
Deep-Palm: 0.40
|
|
| 209 | - | - | - |
Deep-Palm: 0.11
|
|
| 227 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.91
|
|
| 265 | - | - | - |
Deep-Palm: 0.81
|
|
| 342 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.31
|
|
| 346 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.25
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
cerebral cortex
Specificity: 0.500
3/3 (100.0%)
1
LNCaP
Specificity: 0.167
1/1 (100.0%)
1
U937 cell
Specificity: 0.167
1/1 (100.0%)
1
293T cell
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 20 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 57 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 86 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 101 | C → G | 0.002288 | SNP | Missense Mutation | STAD |
| 101 | C → C | 0.002506 | SNP | Silent | COAD |
| 70* | C → ? | 0.001764 | SNP | Nonsense Mutation | LUAD |