Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O15243 | LEPROT | Leptin receptor gene-related protein (Endospanin-1) … | Homo sapiens (Human) | 131 aa |
Protein Details: O15243 (LEPROT)
Protein Information
| Accession | O15243 |
|---|---|
| Protein Names | Leptin receptor gene-related protein (Endospanin-1) (Leptin receptor overlapping transcript protein) (OB-R gene-related protein) (OB-RGRP) |
| Gene Symbol | LEPROT |
| Organism | Homo sapiens (Human) |
| Length | 131 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAGVKALVAL11SFSGAIGLTF21LMLGCALEDY31GVYWPLFVLI41FHAISPIPHF
51-10051IAKRVTYDSD61ATSSACRELA71YFFTTGIVVS81AFGFPVILAR91VAVIKWGACG
101-131101LVLAGNAVIF111LTIQGFFLIF121GRGDDFSWEQ131W
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 25 | Vps55/LEPROT Prokaryotic membrane lipoprotein lipid attachment site profile. | - | - |
Deep-Palm: 0.83
|
|
| 66 | SWISSPALM DBPTM CYSMODDB | Vacuolar protein sorting 55 |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
Deep-Palm: 0.94
|
| 99 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.92
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
LNCaP
Specificity: 0.143
1/1 (100.0%)
1
cerebral cortex
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.571
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.143
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 99 | C → C | 0.001887 | SNP | Silent | UCEC |
| 99* | C → ? | 0.002033 | SNP | Nonsense Mutation | LUSC |