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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O15243 LEPROT; LEPR; OBR Leptin receptor gene-related protein (Endospanin-1) … Homo sapiens (Human) 131 aa

Protein Details: O15243 (LEPROT)

Protein Information
Accession O15243
Protein Names Leptin receptor gene-related protein (Endospanin-1) (Leptin receptor overlapping transcript protein) (OB-R gene-related protein) (OB-RGRP)
Gene Symbol LEPROT; LEPR; OBR
Organism Homo sapiens (Human)
Length 131 aa
Isoforms No isoforms
Related PMIDs 31251020 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.929
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
13
LNCaP cells
Specificity: 0.929
13/46 (28.3%)
1
Cerebral cortex
Specificity: 0.071
1/4 (25.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAGVKALVAL11SFSGAIGLTF21LMLGCALEDY31GVYWPLFVLI41FHAISPIPHF
51-10051IAKRVTYDSD61ATSSACRELA71YFFTTGIVVS81AFGFPVILAR91VAVIKWGACG
101-131101LVLAGNAVIF111LTIQGFFLIF121GRGDDFSWEQ131W
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
66 CYSMODDB SWISSPALM DBPTM Vacuolar protein sorting 55 -
99 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
99 C → C 0.001887 SNP Silent UCEC
194 C → G 0.007299 SNP Missense Mutation READ
346 S → C 0.003460 SNP Missense Mutation CESC
418 C → Y 0.001887 SNP Missense Mutation UCEC
421 R → C 0.001969 SNP Missense Mutation HNSC
421 R → C 0.002141 SNP Missense Mutation SKCM
447 C → Y 0.001887 SNP Missense Mutation UCEC
498 C → Y 0.002033 SNP Missense Mutation LUSC
573 R → C 0.002288 SNP Missense Mutation STAD
573 R → C 0.001887 SNP Missense Mutation UCEC
612 R → C 0.002506 SNP Missense Mutation COAD
675 S → C 0.002288 SNP Missense Mutation STAD
687 C → G 0.001764 SNP Missense Mutation LUAD
952 S → C 0.002033 SNP Missense Mutation LUSC
954 C → F 0.001014 SNP Missense Mutation BRCA
1108 C → F 0.001969 SNP Missense Mutation HNSC
1141 Y → C 0.001887 SNP Missense Mutation UCEC
99* C → ? 0.002033 SNP Nonsense Mutation LUSC
1120* C → ? 0.002288 SNP Nonsense Mutation STAD