Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O15427 | SLC16A3; MCT3; MCT4 | Monocarboxylate transporter 4 (MCT 4) … | Homo sapiens (Human) | 465 aa |
Protein Details: O15427 (SLC16A3)
Protein Information
| Accession | O15427 |
|---|---|
| Protein Names | Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3) |
| Gene Symbol | SLC16A3; MCT3; MCT4 |
| Organism | Homo sapiens (Human) |
| Length | 465 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 26111759 29575903 29733200 31382980 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.250
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
4
PC3 cells
Specificity: 0.250
4/4 (100.0%)
4
T cells
Specificity: 0.250
4/4 (100.0%)
4
HAP1 cells
Specificity: 0.250
4/10 (40.0%)
2
DU145 cells
Specificity: 0.125
2/2 (100.0%)
1
U937 cells
Specificity: 0.062
1/1 (100.0%)
1
HeLa cells
Specificity: 0.062
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGGAVVDEGP11TGVKAPDGGW21GWAVLFGCFV31ITGFSYAFPK41AVSVFFKELI
51-10051QEFGIGYSDT61AWISSILLAM71LYGTGPLCSV81CVNRFGCRPV91MLVGGLFASL
101-150101GMVAASFCRS111IIQVYLTTGV121ITGLGLALNF131QPSLIMLNRY141FSKRRPMANG
151-200151LAAAGSPVFL161CALSPLGQLL171QDRYGWRGGF181LILGGLLLNC191CVCAALMRPL
201-250201VVTAQPGSGP211PRPSRRLLDL221SVFRDRGFVL231YAVAASVMVL241GLFVPPVFVV
251-300251SYAKDLGVPD261TKAAFLLTIL271GFIDIFARPA281AGFVAGLGKV291RPYSVYLFSF
301-350301SMFFNGLADL311AGSTAGDYGG321LVVFCIFFGI331SYGMVGALQF341EVLMAIVGTH
351-400351KFSSAIGLVL361LMEAVAVLVG371PPSGGKLLDA381THVYMYVFIL391AGAEVLTSSL
401-450401ILLLGNFFCI411RKKPKEPQPE421VAAAEEEKLH431KPPADSGVDL441REVEHFLKAE
451-465451PEKNGEVVHT461PETSV
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 78 | Prediction (Medium) | - | - |
| 81 | Prediction (Medium) | - | - |
| 87 | Prediction (Medium) | - | - |
| 108 | Prediction (Medium) | - | - |
| 161 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (Low) | Major Facilitator Superfamily | 29575903 |
| 190 | Prediction (High) | - | - |
| 191 | Prediction (High) | - | - |
| 193 | Prediction (High) | - | - |
| 409 | Prediction (High) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 84 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 293 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 81* | C → ? | 0.001764 | SNP | Nonsense Mutation | LUAD |