Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O15427 | SLC16A3 | Monocarboxylate transporter 4 (MCT 4) … | Homo sapiens (Human) | 465 aa |
Protein Details: O15427 (SLC16A3)
Protein Information
| Accession | O15427 |
|---|---|
| Protein Names | Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3) |
| Gene Symbol | SLC16A3 |
| Organism | Homo sapiens (Human) |
| Length | 465 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 29575903 29733200 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGGAVVDEGP11TGVKAPDGGW21GWAVLFGCFV31ITGFSYAFPK41AVSVFFKELI
51-10051QEFGIGYSDT61AWISSILLAM71LYGTGPLCSV81CVNRFGCRPV91MLVGGLFASL
101-150101GMVAASFCRS111IIQVYLTTGV121ITGLGLALNF131QPSLIMLNRY141FSKRRPMANG
151-200151LAAAGSPVFL161CALSPLGQLL171QDRYGWRGGF181LILGGLLLNC191CVCAALMRPL
201-250201VVTAQPGSGP211PRPSRRLLDL221SVFRDRGFVL231YAVAASVMVL241GLFVPPVFVV
251-300251SYAKDLGVPD261TKAAFLLTIL271GFIDIFARPA281AGFVAGLGKV291RPYSVYLFSF
301-350301SMFFNGLADL311AGSTAGDYGG321LVVFCIFFGI331SYGMVGALQF341EVLMAIVGTH
351-400351KFSSAIGLVL361LMEAVAVLVG371PPSGGKLLDA381THVYMYVFIL391AGAEVLTSSL
401-450401ILLLGNFFCI411RKKPKEPQPE421VAAAEEEKLH431KPPADSGVDL441REVEHFLKAE
451-465451PEKNGEVVHT461PETSV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 28 | - | - | - |
Deep-Palm: 0.76
|
|
| 78 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.93
|
|
| 81 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.94
|
|
| 87 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.93
|
|
| 108 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.97
|
|
| 161 | SWISSPALM DBPTM CYSMODDB | Major Facilitator Superfamily |
HeLa
(29575903)
| - |
GPS-Palm: 0.74
Deep-Palm: 0.97
|
| 190 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.94
|
|
| 191 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.97
|
|
| 193 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.97
|
|
| 325 | - | - | - |
Deep-Palm: 0.88
|
|
| 409 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
Primary T cell
Specificity: 0.500
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.167
1/1 (100.0%)
1
U937 cell
Specificity: 0.167
1/1 (100.0%)
1
HeLa cell
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 84 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 293 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 81* | C → ? | 0.001764 | SNP | Nonsense Mutation | LUAD |