Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O15484 CAPN5; NCL3 Calpain-5 (EC 3.4.22.-) (Calpain htra-3) … Homo sapiens (Human) 640 aa

Protein Details: O15484 (CAPN5)

Protein Information
Accession O15484
Protein Names Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3)
Gene Symbol CAPN5; NCL3
Organism Homo sapiens (Human)
Length 640 aa
Isoforms No isoforms
Related PMIDs 22496122 24357059 26111759 31251020 32944167 36430497
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.740
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
37
LNCaP cells
Specificity: 0.740
37/46 (80.4%)
4
PC3 cells
Specificity: 0.080
4/4 (100.0%)
4
Cerebral cortex
Specificity: 0.080
4/4 (100.0%)
3
T cells
Specificity: 0.060
3/4 (75.0%)
2
Endothelial cells
Specificity: 0.040
2/2 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MFSCVKPYED11QNYSALRRDC21RRRKVLFEDP31LFPATDDSLY41YKGTPGPAVR
51-10051WKRPKGICED61PRLFVDGISS71HDLHQGQVGN81CWFVAACSSL91ASRESLWQKV
101-150101IPDWKEQEWD111PEKPNAYAGI121FHFHFWRFGE131WVDVVIDDRL141PTVNNQLIYC
151-200151HSNSRNEFWC161ALVEKAYAKL171AGCYQALDGG181NTADALVDFT191GGVSEPIDLT
201-250201EGDFANDETK211RNQLFERMLK221VHSRGGLISA231SIKAVTAADM241EARLACGLVK
251-300251GHAYAVTDVR261KVRLGHGLLA271FFKSEKLDMI281RLRNPWGERE291WNGPWSDTSE
301-350301EWQKVSKSER311EKMGVTVQDD321GEFWMTFEDV331CRYFTDIIKC341RVINTSHLSI
351-400351HKTWEEARLH361GAWTLHEDPR371QNRGGGCINH381KDTFFQNPQY391IFEVKKPEDE
401-450401VLICIQQRPK411RSTRREGKGE421NLAIGFDIYK431VEENRQYRMH441SLQHKAASSI
451-500451YINSRSVFLR461TDQPEGRYVI471IPTTFEPGHT481GEFLLRVFTD491VPSNCRELRL
501-550501DEPPHTCWSS511LCGYPQLVTQ521VHVLGAAGLK531DSPTGANSYV541IIKCEGDKVR
551-600551SAVQKGTSTP561EYNVKGIFYR571KKLSQPITVQ581VWNHRVLKDE591FLGQVHLKAD
601-640601PDNLQALHTL611HLRDRNSRQP621SNLPGTVAVH631ILSSTSLMAV
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
4 Prediction (High) - -
20 Prediction (Medium) - -
58 Prediction (Medium) - -
87 Prediction (Medium) - -
173 Prediction (Medium) - -
246 Prediction (Medium) - -
331 Prediction (Low) - -
340 Prediction (Low) - -
377 Prediction (Low) - -
404 Prediction (High) - -
495 Prediction (Medium) - -
544 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
254 Y → C 0.002427 SNP Missense Mutation BLCA
263 R → C 0.002033 SNP Missense Mutation LUSC
267 G → C 0.002545 SNP Missense Mutation GBM
283 R → C 0.003460 SNP Missense Mutation CESC
286 W → C 0.003460 SNP Missense Mutation CESC
373 R → C 0.002288 SNP Missense Mutation STAD
419 G → C 0.002506 SNP Missense Mutation COAD
467 R → C 0.007299 SNP Missense Mutation READ
499 R → C 0.001887 SNP Missense Mutation UCEC
570 R → C 0.005618 SNP Missense Mutation PAAD