Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O15551 | CLDN3 | Claudin-3 (Clostridium perfringens enterotoxin receptor … | Homo sapiens (Human) | 220 aa |
Protein Details: O15551 (CLDN3)
Protein Information
| Accession | O15551 |
|---|---|
| Protein Names | Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2) (Rat ventral prostate.1 protein homolog) (hRVP1) |
| Gene Symbol | CLDN3 |
| Organism | Homo sapiens (Human) |
| Length | 220 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 |
| Database Sources | PTMDdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSMGLEITGT11ALAVLGWLGT21IVCCALPMWR31VSAFIGSNII41TSQNIWEGLW
51-10051MNCVVQSTGQ61MQCKVYDSLL71ALPQDLQAAR81ALIVVAILLA91AFGLLVALVG
101-150101AQCTNCVQDD111TAKAKITIVA121GVLFLLAALL131TLVPVSWSAN141TIIRDFYNPV
151-200151VPEAQKREMG161AGLYVGWAAA171ALQLLGGALL181CCSCPPREKK191YTATKVVYSA
201-220201PRSTGPGASL211GTGYDRKDYV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 23 | Claudin | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.94
|
|
| 24 | Claudin | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.94
|
|
| 53 | - | - | - |
Deep-Palm: 0.03
|
|
| 63 | - | - | - |
Deep-Palm: 0.33
|
|
| 103 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
| 106 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.95
|
| 181 | PTMD SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.98
|
| 182 | PTMD DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.98
|
| 184 | PTMD DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
PC3
Specificity: 0.500
4/4 (100.0%)
3
LNCaP
Specificity: 0.375
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 50 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |