Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O35604 | Npc1 | NPC intracellular cholesterol transporter 1 … | Mus musculus (Mouse) | 1277 aa |
Protein Details: O35604 (Npc1)
Protein Information
| Accession | O35604 |
|---|---|
| Protein Names | NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein) |
| Gene Symbol | Npc1 |
| Organism | Mus musculus (Mouse) |
| Length | 1277 aa |
| Isoforms | No isoforms |
| Related PMIDs | 28526873 29217618 31772009 35477839 37925639 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGAHHPALGL11LLLLLCPAQV21FSQSCVWYGE31CGIATGDKRY41NCKYSGPPKP
51-10051LPKDGYDLVQ61ELCPGLFFDN71VSLCCDIQQL81QTLKSNLQLP91LQFLSRCPSC
101-150101FYNLMTLFCE111LTCSPHQSQF121LNVTATEDYF131DPKTQENKTN141VKELEYFVGQ
151-200151SFANAMYNAC161RDVEAPSSNE171KALGLLCGRD181ARACNATNWI191EYMFNKDNGQ
201-250201APFTIIPVFS211DLSILGMEPM221RNATKGCNES231VDEVTGPCSC241QDCSIVCGPK
251-300251PQPPPPPMPW261RIWGLDAMYV271IMWVTYVAFL281FVFFGALLAV291WCHRRRYFVS
301-350301EYTPIDSNIA311FSVNSSDKGE321ASCCDPLGAA331FDDCLRRMFT341KWGAFCVRNP
351-400351TCIIFFSLAF361ITVCSSGLVF371VQVTTNPVEL381WSAPHSQARL391EKEYFDKHFG
401-450401PFFRTEQLII411QAPNTSVHIY421EPYPAGADVP431FGPPLNKEIL441HQVLDLQIAI
451-500451ESITASYNNE461TVTLQDICVA471PLSPYNKNCT481IMSVLNYFQN491SHAVLDSQVG
501-550501DDFYIYADYH511THFLYCVRAP521ASLNDTSLLH531GPCLGTFGGP541VFPWLVLGGY
551-600551DDQNYNNATA561LVITFPVNNY571YNDTERLQRA581WAWEKEFISF591VKNYKNPNLT
601-650601ISFTAERSIE611DELNRESNSD621VFTVIISYVV631MFLYISLALG641HIQSCSRLLV
651-700651DSKISLGIAG661ILIVLSSVAC671SLGIFSYMGM681PLTLIVIEVI691PFLVLAVGVD
701-750701NIFILVQTYQ711RDERLQEETL721DQQLGRILGE731VAPTMFLSSF741SETSAFFFGA
751-800751LSSMPAVHTF761SLFAGMAVLI771DFLLQITCFV781SLLGLDIKRQ791EKNHLDILCC
801-850801VRGADDGQGS811HASESYLFRF821FKNYFAPLLL831KDWLRPIVVA841VFVGVLSFSV
851-900851AVVNKVDIGL861DQSLSMPNDS871YVIDYFKSLA881QYLHSGPPVY891FVLEEGYNYS
901-950901SRKGQNMVCG911GMGCDNDSLV921QQIFNAAELD931TYTRVGFAPS941SWIDDYFDWV
951-1000951SPQSSCCRLY961NVTHQFCNAS971VMDPTCVRCR981PLTPEGKQRP991QGKEFMKFLP
1001-10501001MFLSDNPNPK1011CGKGGHAAYG1021SAVNIVGDDT1031YIGATYFMTY1041HTILKTSADY
1051-11001051TDAMKKARLI1061ASNITETMRS1071KGSDYRVFPY1081SVFYVFYEQY1091LTIIDDTIFN
1101-11501101LSVSLGSIFL1111VTLVVLGCEL1121WSAVIMCITI1131AMILVNMFGV1141MWLWGISLNA
1151-12001151VSLVNLVMSC1161GISVEFCSHI1171TRAFTMSTKG1181SRVSRAEEAL1191AHMGSSVFSG
1201-12501201ITLTKFGGIV1211VLAFAKSQIF1221EIFYFRMYLA1231MVLLGATHGL1241IFLPVLLSYI
1251-12771251GPSVNKAKRH1261TTYERYRGTE1271RERLLNF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 16 | - | - | - |
Deep-Palm: 0.88
|
|
| 25 | - | - | - |
Deep-Palm: 0.92
|
|
| 31 | - | - | - |
Deep-Palm: 0.09
|
|
| 42 | Niemann-Pick C1, N-terminal | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.21
|
|
| 63 | - | - | - |
Deep-Palm: 0.69
|
|
| 74 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.82
|
|
| 75 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.80
|
|
| 97 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.69
|
|
| 100 | - | - | - |
Deep-Palm: 0.43
|
|
| 109 | - | - | - |
Deep-Palm: 0.05
|
|
| 113 | - | - | - |
Deep-Palm: 0.08
|
|
| 160 | - | - | - |
Deep-Palm: 0.85
|
|
| 177 | Niemann-Pick C1 N terminus |
Liver
(28526873)
| - |
GPS-Palm: 0.89
Deep-Palm: 0.96
|
|
| 184 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.90
|
|
| 227 | - | - | - |
Deep-Palm: 0.13
|
|
| 238 | - | - | - |
Deep-Palm: 0.06
|
|
| 240 | - | - | - |
Deep-Palm: 0.04
|
|
| 243 | - | - | - |
Deep-Palm: 0.06
|
|
| 247 | - | - | - |
Deep-Palm: 0.05
|
|
| 292 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.92
|
|
| 323 | SWISSPALM DBPTM CYSMODDB | - |
Forebrain
(28680068)
| - |
Deep-Palm: 0.75
|
| 324 | SWISSPALM DBPTM CYSMODDB | - |
Liver
(28526873)
Forebrain
(28680068)
| - |
Deep-Palm: 0.82
|
| 334 | SWISSPALM DBPTM CYSMODDB | - |
Forebrain
(28680068)
| - |
GPS-Palm: 0.93
Deep-Palm: 0.68
|
| 346 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.21
|
|
| 352 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.14
|
|
| 364 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.21
|
|
| 468 | - | - | - |
Deep-Palm: 0.07
|
|
| 479 | - | - | - |
Deep-Palm: 0.07
|
|
| 516 | - | - | - |
Deep-Palm: 0.13
|
|
| 533 | - | - | - |
Deep-Palm: 0.96
|
|
| 645 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.94
|
|
| 670 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.94
|
|
| 778 | - | - | - |
Deep-Palm: 0.81
|
|
| 799 | SWISSPALM DBPTM CYSMODDB | Sterol-sensing domain of SREBP cleavage-activation |
Forebrain
(28680068)
| - |
Deep-Palm: 0.88
|
| 800 | SWISSPALM DBPTM CYSMODDB | Sterol-sensing domain of SREBP cleavage-activation |
Liver
(28526873)
Forebrain
(28680068)
| - |
GPS-Palm: 0.70
Deep-Palm: 0.86
|
| 909 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.20
|
|
| 914 | - | - | - |
Deep-Palm: 0.27
|
|
| 956 | - | - | - |
Deep-Palm: 0.05
|
|
| 957 | - | - | - |
Deep-Palm: 0.03
|
|
| 967 | - | - | - |
Deep-Palm: 0.07
|
|
| 976 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.10
|
|
| 979 | - |
brain
(39008777)
| - |
GPS-Palm: 0.66
Deep-Palm: 0.22
|
|
| 1011 | - | - | - |
Deep-Palm: 0.45
|
|
| 1118 | - | - | - |
Deep-Palm: 0.83
|
|
| 1127 | - | - | - |
Deep-Palm: 0.06
|
|
| 1160 | - | - | - |
Deep-Palm: 0.23
|
|
| 1167 | - | - | - |
Deep-Palm: 0.09
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
Liver
Specificity: 0.500
4/4 (100.0%)
2
Testis
Specificity: 0.250
2/2 (100.0%)
1
Raw 264.7
Specificity: 0.125
1/1 (100.0%)
1
NSC
Specificity: 0.125
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.