Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O43175 | PHGDH; PGDH3 | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) … | Homo sapiens (Human) | 533 aa |
Protein Details: O43175 (PHGDH)
Protein Information
| Accession | O43175 |
|---|---|
| Protein Names | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) |
| Gene Symbol | PHGDH; PGDH3 |
| Organism | Homo sapiens (Human) |
| Length | 533 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29575903 29733200 31251020 31382980 32944167 36430497 37611173 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.590
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.590
36/46 (78.3%)
10
HAP1 cells
Specificity: 0.164
10/10 (100.0%)
4
PC3 cells
Specificity: 0.066
4/4 (100.0%)
4
293T cells
Specificity: 0.066
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.066
4/4 (100.0%)
2
Jurkat T cells
Specificity: 0.033
2/25 (8.0%)
1
U937 cells
Specificity: 0.016
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAFANLRKVL11ISDSLDPCCR21KILQDGGLQV31VEKQNLSKEE41LIAELQDCEG
51-10051LIVRSATKVT61ADVINAAEKL71QVVGRAGTGV81DNVDLEAATR91KGILVMNTPN
101-150101GNSLSAAELT111CGMIMCLARQ121IPQATASMKD131GKWERKKFMG141TELNGKTLGI
151-200151LGLGRIGREV161ATRMQSFGMK171TIGYDPIISP181EVSASFGVQQ191LPLEEIWPLC
201-250201DFITVHTPLL211PSTTGLLNDN221TFAQCKKGVR231VVNCARGGIV241DEGALLRALQ
251-300251SGQCAGAALD261VFTEEPPRDR271ALVDHENVIS281CPHLGASTKE291AQSRCGEEIA
301-350301VQFVDMVKGK311SLTGVVNAQA321LTSAFSPHTK331PWIGLAEALG341TLMRAWAGSP
351-400351KGTIQVITQG361TSLKNAGNCL371SPAVIVGLLK381EASKQADVNL391VNAKLLVKEA
401-450401GLNVTTSHSP411AAPGEQGFGE421CLLAVALAGA431PYQAVGLVQG441TTPVLQGLNG
451-500451AVFRPEVPLR461RDLPLLLFRT471QTSDPAMLPT481MIGLLAEAGV491RLLSYQTSLV
501-533501SDGETWHVMG511ISSLLPSLEA521WKQHVTEAFQ531FHF
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 18 | Experimental Prediction (High) | - | 37611173 |
| 19 | Prediction (Medium) | - | - |
| 48 | Prediction (Medium) | - | - |
| 111 | Prediction (Low) | - | - |
| 116 | Prediction (Medium) | - | - |
| 225 | Prediction (Medium) | - | - |
| 234 | Prediction (Medium) | - | - |
| 254 | Prediction (Medium) | - | - |
| 281 | Prediction (Low) | - | - |
| 369 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | 29575903 |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 254 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 295 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |