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UniProt ID Gene Symbol Protein Name Organism Length Action
O43242 PSMD3 26S proteasome non-ATPase regulatory subunit … Homo sapiens (Human) 534 aa

Protein Details: O43242 (PSMD3)

Protein Information
AccessionO43242
Protein Names26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)
Gene SymbolPSMD3
OrganismHomo sapiens (Human)
Length534 aa
IsoformsNo isoforms
Related PMIDs 29733200
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MKQEGSARRR11GADKAKPPPG21GGEQEPPPPP31APQDVEMKEE41AATGGGSTGE
51-10051ADGKTAAAAA61EHSQRELDTV71TLEDIKEHVK81QLEKAVSGKE91PRFVLRALRM
101-150101LPSTSRRLNH111YVLYKAVQGF121FTSNNATRDF131LLPFLEEPMD141TEADLQFRPR
151-200151TGKAASTPLL161PEVEAYLQLL171VVIFMMNSKR181YKEAQKISDD191LMQKISTQNR
201-250201RALDLVAAKC211YYYHARVYEF221LDKLDVVRSF231LHARLRTATL241RHDADGQATL
251-300251LNLLLRNYLH261YSLYDQAEKL271VSKSVFPEQA281NNNEWARYLY291YTGRIKAIQL
301-350301EYSEARRTMT311NALRKAPQHT321AVGFKQTVHK331LLIVVELLLG341EIPDRLQFRQ
351-400351PSLKRSLMPY361FLLTQAVRTG371NLAKFNQVLD381QFGEKFQADG391TYTLIIRLRH
401-450401NVIKTGVRMI411SLSYSRISLA421DIAQKLQLDS431PEDAEFIVAK441AIRDGVIEAS
451-500451INHEKGYVQS461KEMIDIYSTR471EPQLAFHQRI481SFCLDIHNMS491VKAMRFPPKS
501-534501YNKDLESAEE511RREREQQDLE521FAKEMAEDDD531DSFP
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
210 - - -
GPS-Palm: 0.90
Deep-Palm: 0.82
483 - - -
Deep-Palm: 0.42
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
HAP1 cell
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
119 G → C 0.001764 SNP Missense Mutation LUAD
166 Y → C 0.002288 SNP Missense Mutation STAD
166 Y → C 0.001969 SNP Missense Mutation HNSC
228 R → C 0.001887 SNP Missense Mutation UCEC
314 R → C 0.002506 SNP Missense Mutation COAD
314 R → C 0.001887 SNP Missense Mutation UCEC
479 R → C 0.001887 SNP Missense Mutation UCEC
481 S → C 0.002427 SNP Missense Mutation BLCA