Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O43505 | B4GAT1 | Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) … | Homo sapiens (Human) | 415 aa |
Protein Details: O43505 (B4GAT1)
Protein Information
| Accession | O43505 |
|---|---|
| Protein Names | Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1) |
| Gene Symbol | B4GAT1 |
| Organism | Homo sapiens (Human) |
| Length | 415 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 29733200 31251020 32944167 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MQMSYAIRCA11FYQLLLAALM21LVAMLQLLYL31SLLSGLHGQE41EQDQYFEFFP
51-10051PSPRSVDQVK61AQLRTALASG71GVLDASGDYR81VYRGLLKTTM91DPNDVILATH
101-150101ASVDNLLHLS111GLLERWEGPL121SVSVFAATKE131EAQLATVLAY141ALSSHCPDMR
151-200151ARVAMHLVCP161SRYEAAVPDP171REPGEFALLR181SCQEVFDKLA191RVAQPGINYA
201-250201LGTNVSYPNN211LLRNLAREGA221NYALVIDVDM231VPSEGLWRGL241REMLDQSNQW
251-300251GGTALVVPAF261EIRRARRMPM271NKNELVQLYQ281VGEVRPFYYG291LCTPCQAPTN
301-350301YSRWVNLPEE311SLLRPAYVVP321WQDPWEPFYV331AGGKVPTFDE341RFRQYGFNRI
351-400351SQACELHVAG361FDFEVLNEGF371LVHKGFKEAL381KFHPQKEAEN391QHNKILYRQF
401-415401KQELKAKYPN411SPRRC
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 9 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.02
|
| 146 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.86
|
|
| 159 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.90
Deep-Palm: 0.64
|
|
| 182 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.97
|
|
| 292 | - | - | - |
Deep-Palm: 0.38
|
|
| 295 | - | - | - |
Deep-Palm: 0.44
|
|
| 354 | - | - | - |
Deep-Palm: 0.46
|
|
| 415 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
4
LNCaP
Specificity: 0.235
4/4 (100.0%)
3
Jurkat T cell
Specificity: 0.176
3/3 (100.0%)
3
PC3
Specificity: 0.176
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.059
1/1 (100.0%)
1
heart
Specificity: 0.059
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
Cerebral Cortex (Mass)
Specificity: 0.176
3/4 (75.0%)
2
LNCaP cells (Mass)
Specificity: 0.118
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 162 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 182 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 266 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 266 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 288 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |