Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O43561 | LAT | Linker for activation of T-cells … | Homo sapiens (Human) | 262 aa |
Protein Details: O43561 (LAT)
Protein Information
| Accession | O43561 |
|---|---|
| Protein Names | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) |
| Gene Symbol | LAT |
| Organism | Homo sapiens (Human) |
| Length | 262 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 26111759 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEEAILVPCV11LGLLLLPILA21MLMALCVHCH31RLPGSYDSTS41SDSLYPRGIQ
51-10051FKRPHTVAPW61PPAYPPVTSY71PPLSQPDLLP81IPRSPQPLGG91SHRTPSSRRD
101-150101SDGANSVASY111ENEGASGIRG121AQAGWGVWGP131SWTRLTPVSL141PPEPACEDAD
151-200151EDEDDYHNPG161YLVVLPDSTP171ATSTAAPSAP181ALSTPGIRDS191AFSMESIDDY
201-250201VNVPESGESA211EASLDGSREY221VNVSQELHPG231AAKTEPAALS241SQEAEEVEEE
251-262251GAPDYENLQE261LN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 9 | Linker-for-activation of T cells (LAT) protein | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.14
|
|
| 26 | DBPTM SWISSPALM | Linker-for-activation of T cells (LAT) protein Linker for activation of T-cells | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.98
|
| 29 | DBPTM SWISSPALM | Linker-for-activation of T cells (LAT) protein Linker for activation of T-cells | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.96
|
| 146 | - | - | - |
Deep-Palm: 0.27
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
6
Jurkat T cell
Specificity: 0.667
6/6 (100.0%)
3
Primary T cell
Specificity: 0.333
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| ? | ? → ? | 0.001969 | SNP | Missense Mutation | LGG |