Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O43597 | SPRY2 | Protein sprouty homolog 2 (Spry-2) | Homo sapiens (Human) | 315 aa |
Protein Details: O43597 (SPRY2)
Protein Information
| Accession | O43597 |
|---|---|
| Protein Names | Protein sprouty homolog 2 (Spry-2) |
| Gene Symbol | SPRY2 |
| Organism | Homo sapiens (Human) |
| Length | 315 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 25914232 32944167 36430497 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
4
Cerebral cortex
Specificity: 0.444
4/4 (100.0%)
2
DU145 cells
Specificity: 0.222
2/2 (100.0%)
2
PC3 cells
Specificity: 0.222
2/4 (50.0%)
1
CEMx174 cells
Specificity: 0.111
1/3 (33.3%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MEARAQSGNG11SQPLLQTPRD21GGRQRGEPDP31RDALTQQVHV41LSLDQIRAIR
51-10051NTNEYTEGPT61VVPRPGLKPA71PRPSTQHKHE81RLHGLPEHRQ91PPRLQHSQVH
101-150101SSARAPLSRS111ISTVSSGSRS121STRTSTSSSS131SEQRLLGSSF141SSGPVADGII
151-200151RVQPKSELKP161GELKPLSKED171LGLHAYRCED181CGKCKCKECT191YPRPLPSDWI
201-250201CDKQCLCSAQ211NVIDYGTCVC221CVKGLFYHCS231NDDEDNCADN241PCSCSQSHCC
251-300251TRWSAMGVMS261LFLPCLWCYL271PAKGCLKLCQ281GCYDRVNRPG291CRCKNSNTVC
301-315301CKVPTVPPRN311FEKPT
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 201 | Prediction (Low) | - | - |
| 265 | SWISSPALM Prediction (Medium) | Sprouty protein (Spry) | - |
| 268 | SWISSPALM Prediction (Medium) | Sprouty protein (Spry) | - |
| 275 | Prediction (Medium) | - | - |
| 279 | Prediction (High) | - | - |
| 282 | Prediction (Medium) | - | - |
| 300 | Prediction (Medium) | - | - |
| 301 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 172 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 201 | C → C | 0.001014 | SNP | Silent | BRCA |
| 201 | C → Afs*12 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 201 | C → C | 0.001887 | SNP | Silent | UCEC |
| 221 | C → Y | 0.002427 | SNP | Missense Mutation | BLCA |
| 249 | C → Y | 0.002976 | SNP | Missense Mutation | KIRC |
| 265 | C → delins* | 0.001764 | INS | Nonsense Mutation | LUAD |
| 291 | C → R | 0.002506 | SNP | Missense Mutation | COAD |
| 292 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 244* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |