Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O43597 | SPRY2 | Protein sprouty homolog 2 (Spry-2) | Homo sapiens (Human) | 315 aa |
Protein Details: O43597 (SPRY2)
Protein Information
| Accession | O43597 |
|---|---|
| Protein Names | Protein sprouty homolog 2 (Spry-2) |
| Gene Symbol | SPRY2 |
| Organism | Homo sapiens (Human) |
| Length | 315 aa |
| Isoforms | No isoforms |
| Related PMIDs | 25914232 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEARAQSGNG11SQPLLQTPRD21GGRQRGEPDP31RDALTQQVHV41LSLDQIRAIR
51-10051NTNEYTEGPT61VVPRPGLKPA71PRPSTQHKHE81RLHGLPEHRQ91PPRLQHSQVH
101-150101SSARAPLSRS111ISTVSSGSRS121STRTSTSSSS131SEQRLLGSSF141SSGPVADGII
151-200151RVQPKSELKP161GELKPLSKED171LGLHAYRCED181CGKCKCKECT191YPRPLPSDWI
201-250201CDKQCLCSAQ211NVIDYGTCVC221CVKGLFYHCS231NDDEDNCADN241PCSCSQSHCC
251-300251TRWSAMGVMS261LFLPCLWCYL271PAKGCLKLCQ281GCYDRVNRPG291CRCKNSNTVC
301-315301CKVPTVPPRN311FEKPT
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 178 | - | - | - |
Deep-Palm: 0.56
|
|
| 181 | - | - | - |
Deep-Palm: 0.10
|
|
| 184 | - | - | - |
Deep-Palm: 0.05
|
|
| 186 | - | - | - |
Deep-Palm: 0.05
|
|
| 189 | - | - | - |
Deep-Palm: 0.02
|
|
| 201 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.09
|
|
| 205 | - | - | - |
Deep-Palm: 0.09
|
|
| 207 | - | - | - |
Deep-Palm: 0.07
|
|
| 218 | - | - | - |
Deep-Palm: 0.04
|
|
| 220 | - | - | - |
Deep-Palm: 0.03
|
|
| 221 | - | - | - |
Deep-Palm: 0.03
|
|
| 229 | - | - | - |
Deep-Palm: 0.02
|
|
| 237 | - | - | - |
Deep-Palm: 0.03
|
|
| 242 | - | - | - |
Deep-Palm: 0.02
|
|
| 244 | - | - | - |
Deep-Palm: 0.02
|
|
| 249 | - | - | - |
Deep-Palm: 0.04
|
|
| 250 | - | - | - |
Deep-Palm: 0.04
|
|
| 265 | SWISSPALM | Sprouty protein (Spry) | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.84
|
| 268 | SWISSPALM | Sprouty protein (Spry) | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.82
|
| 275 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.90
|
|
| 279 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.10
|
|
| 282 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.13
|
|
| 291 | - | - | - |
Deep-Palm: 0.06
|
|
| 293 | - | - | - |
Deep-Palm: 0.05
|
|
| 300 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.13
|
|
| 301 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.11
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.400
4/4 (100.0%)
2
PC3
Specificity: 0.200
2/2 (100.0%)
1
CEM 174 cell
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.300
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 172 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 201 | C → C | 0.001014 | SNP | Silent | BRCA |
| 201 | C → Afs*12 | 0.002747 | DEL | Frame Shift Del | LIHC |
| 201 | C → C | 0.001887 | SNP | Silent | UCEC |
| 221 | C → Y | 0.002427 | SNP | Missense Mutation | BLCA |
| 249 | C → Y | 0.002976 | SNP | Missense Mutation | KIRC |
| 265 | C → delins* | 0.001764 | INS | Nonsense Mutation | LUAD |
| 291 | C → R | 0.002506 | SNP | Missense Mutation | COAD |
| 292 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 244* | C → ? | 0.002545 | SNP | Nonsense Mutation | GBM |