Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O43707-2 | ACTN4 | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | Homo sapiens (Human) | 692 aa |
Protein Details: O43707-2 (ACTN4)
Protein Information
| Accession | O43707-2 |
|---|---|
| Protein Names | Alpha-actinin-4 (Non-muscle alpha-actinin 4) |
| Gene Symbol | ACTN4 |
| Organism | Homo sapiens (Human) |
| Length | 692 aa |
| Isoforms | |
| Related PMIDs | 31251020 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MVDYHAANQS11YQYGPSSAGN21GAGGGGSMGD31YMAQEDDWDR41DLLLDPAWEK
51-10051QQRKAETAAN61RICKVLAVNQ71ENEHLMEDYE81KLASDLLEWI91RRTIPWLEDR
101-150101VPQKTIQEMQ111QKLEDFRDYR121RVHKPPKVQE131KCQLEINFNT141LQTKLRLSNR
151-200151PAFMPSEGKM161VSDINNGWQH171LEQAEKGYEE181WLLNEIRRLE191RLDHLAEKFR
201-250201QKASIHEAWT211DGKEAMLKHR221DYETATLSDI231KALIRKHEAF241ESDLAAHQDR
251-300251VEQIAAIAQE261LNELDYYDSH271NVNTRCQKIC281DQWDALGSLT291HSRREALEKT
301-350301EKQLEAIDQL311HLEYAKRAAP321FNNWMESAME331DLQDMFIVHT341IEEIEGLISA
351-400351HDQFKSTLPD361ADREREAILA371IHKEAQRIAE381SNHIKLSGSN391PYTTVTPQII
401-450401NSKWEKVQQL411VPKRDHALLE421EQSKQQSNEH431LRRQFASQAN441VVGPWIQTKM
451-500451EEIGRISIEM461NGTLEDQLSH471LKQYERSIVD481YKPNLDLLEQ491QHQLIQEALI
501-550501FDNKHTNYTM511EHIRVGWEQL521LTTIARTINE531VENQILTRDA541KGISQEQMQE
551-600551FRASFNHFDK561DHGGALGPEE571FKACLISLGY581DVENDRQGEA591EFNRIMSLVD
601-650601PNHSGLVTFQ611AFIDFMSRET621TDTDTADQVI631ASFKVLAGDK641NFITAEELRR
651-692651ELPPDQAEYC661IARMAPYQGP671DAVPGALDYK681SFSTALYGES691DL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 60 | - | - | - |
Deep-Palm: 0.68
|
|
| 173 | - | - | - |
Deep-Palm: 0.96
|
|
| 280 | - |
HeLa
(29575903)
| - | - | |
| 282 | - | - | - |
Deep-Palm: 0.81
|
|
| 351 | - | - | - |
Deep-Palm: 0.82
|
|
| 495 | - | - | - |
Deep-Palm: 0.09
|
|
| 499 | - | - | - |
Deep-Palm: 0.11
|
|
| 574 | - |
HeLa
(29575903)
| - | - | |
| 793 | - | - | - |
Deep-Palm: 0.93
|
|
| 879 | - | - | - |
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
LNCaP
Specificity: 0.500
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.500
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 195 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 311 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 319 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 340 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 365 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 365 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 423 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 469 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 502 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 512 | R → C | 0.012195 | SNP | Missense Mutation | MESO |
| 536 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 584 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 651 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 695 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 813 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 823 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 902 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |