Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O43823 | AKAP8 | A-kinase anchor protein 8 (AKAP-8) … | Homo sapiens (Human) | 692 aa |
Protein Details: O43823 (AKAP8)
Protein Information
| Accession | O43823 |
|---|---|
| Protein Names | A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95) |
| Gene Symbol | AKAP8 |
| Organism | Homo sapiens (Human) |
| Length | 692 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDQGYGGYGA11WSAGPANTQG21AYGTGVASWQ31GYENYNYYGA41QNTSVTTGAT
51-10051YSYGPASWEA61AKANDGGLAA71GAPAMHMASY81GPEPCTDNSD91SLIAKINQRL
101-150101DMMSKEGGRG111GSGGGGEGIQ121DRESSFRFQP131FESYDSRPCL141PEHNPYRPSY
151-200151SYDYEFDLGS161DRNGSFGGQY171SECRDPARER181GSLDGFMRGR191GQGRFQDRSN
201-250201PGTFMRSDPF211VPPAASSEPL221STPWNELNYV231GGRGLGGPSP241SRPPPSLFSQ
251-300251SMAPDYGVMG261MQGAGGYDST271MPYGCGRSQP281RMRDRDRPKR291RGFDRFGPDG
301-350301TGRKRKQFQL311YEEPDTKLAR321VDSEGDFSEN331DDAAGDFRSG341DEEFKGEDEL
351-400351CDSGRQRGEK361EDEDEDVKKR371REKQRRRDRT381RDRAADRIQF391ACSVCKFRSF
401-450401DDEEIQKHLQ411SKFHKETLRF421ISTKLPDKTV431EFLQEYIVNR441NKKIEKRRQE
451-500451LMEKETAKPK461PDPFKGIGQE471HFFKKIEAAH481CLACDMLIPA491QPQLLQRHLH
501-550501SVDHNHNRRL511AAEQFKKTSL521HVAKSVLNNR531HIVKMLEKYL541KGEDPFTSET
551-600551VDPEMEGDDN561LGGEDKKETP571EEVAADVLAE581VITAAVRAVD591GEGAPAPESS
601-650601GEPAEDEGPT611DTAEAGSDPQ621AEQLLEEQVP631CGTAHEKGVP641KARSEAAEAG
651-692651NGAETMAAEA661ESAQTRVAPA671PAAADAEVEQ681TDAESKDAVP691TE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 85 | - | - | - |
Deep-Palm: 0.47
|
|
| 139 | - | - | - |
Deep-Palm: 0.12
|
|
| 173 | - | - | - |
Deep-Palm: 0.88
|
|
| 275 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.46
|
|
| 351 | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.88
|
|
| 392 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.55
|
|
| 395 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.31
|
|
| 481 | - | - | - |
Deep-Palm: 0.66
|
|
| 484 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.30
|
|
| 631 | - | - | - |
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
2
LNCaP
Specificity: 0.667
2/2 (100.0%)
1
U937 cell
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 85 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 127 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 152 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 173 | C → C | 0.002506 | SNP | Silent | COAD |
| 251 | S → C | 0.012195 | SNP | Missense Mutation | MESO |
| 383 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 398 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 448 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 484 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |