Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O43823 AKAP8; AKAP95 A-kinase anchor protein 8 (AKAP-8) … Homo sapiens (Human) 692 aa

Protein Details: O43823 (AKAP8)

Protein Information
Accession O43823
Protein Names A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)
Gene Symbol AKAP8; AKAP95
Organism Homo sapiens (Human)
Length 692 aa
Isoforms No isoforms
Related PMIDs 31251020 31382980
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.958
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
23
LNCaP cells
Specificity: 0.958
23/46 (50.0%)
1
U937 cells
Specificity: 0.042
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MDQGYGGYGA11WSAGPANTQG21AYGTGVASWQ31GYENYNYYGA41QNTSVTTGAT
51-10051YSYGPASWEA61AKANDGGLAA71GAPAMHMASY81GPEPCTDNSD91SLIAKINQRL
101-150101DMMSKEGGRG111GSGGGGEGIQ121DRESSFRFQP131FESYDSRPCL141PEHNPYRPSY
151-200151SYDYEFDLGS161DRNGSFGGQY171SECRDPARER181GSLDGFMRGR191GQGRFQDRSN
201-250201PGTFMRSDPF211VPPAASSEPL221STPWNELNYV231GGRGLGGPSP241SRPPPSLFSQ
251-300251SMAPDYGVMG261MQGAGGYDST271MPYGCGRSQP281RMRDRDRPKR291RGFDRFGPDG
301-350301TGRKRKQFQL311YEEPDTKLAR321VDSEGDFSEN331DDAAGDFRSG341DEEFKGEDEL
351-400351CDSGRQRGEK361EDEDEDVKKR371REKQRRRDRT381RDRAADRIQF391ACSVCKFRSF
401-450401DDEEIQKHLQ411SKFHKETLRF421ISTKLPDKTV431EFLQEYIVNR441NKKIEKRRQE
451-500451LMEKETAKPK461PDPFKGIGQE471HFFKKIEAAH481CLACDMLIPA491QPQLLQRHLH
501-550501SVDHNHNRRL511AAEQFKKTSL521HVAKSVLNNR531HIVKMLEKYL541KGEDPFTSET
551-600551VDPEMEGDDN561LGGEDKKETP571EEVAADVLAE581VITAAVRAVD591GEGAPAPESS
601-650601GEPAEDEGPT611DTAEAGSDPQ621AEQLLEEQVP631CGTAHEKGVP641KARSEAAEAG
651-692651NGAETMAAEA661ESAQTRVAPA671PAAADAEVEQ681TDAESKDAVP691TE
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
275 Prediction (Medium) - -
351 Prediction (Low) - -
392 Prediction (Medium) - -
395 Prediction (Medium) - -
484 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
85 C → Y 0.001887 SNP Missense Mutation UCEC
127 R → C 0.002545 SNP Missense Mutation GBM
152 Y → C 0.001887 SNP Missense Mutation UCEC
173 C → C 0.002506 SNP Silent COAD
251 S → C 0.012195 SNP Missense Mutation MESO
383 R → C 0.002288 SNP Missense Mutation STAD
398 R → C 0.001014 SNP Missense Mutation BRCA
448 R → C 0.002545 SNP Missense Mutation GBM
484 C → Y 0.002288 SNP Missense Mutation STAD