Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O60603 | TLR2 | Toll-like receptor 2 (Toll/interleukin-1 receptor-like … | Homo sapiens (Human) | 784 aa |
Protein Details: O60603 (TLR2)
Protein Information
| Accession | O60603 |
|---|---|
| Protein Names | Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282) |
| Gene Symbol | TLR2 |
| Organism | Homo sapiens (Human) |
| Length | 784 aa |
| Isoforms | No isoforms |
| Related PMIDs | 33636221 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPHTLWMVWV11LGVIISLSKE21ESSNQASLSC31DRNGICKGSS41GSLNSIPSGL
51-10051TEAVKSLDLS61NNRITYISNS71DLQRCVNLQA81LVLTSNGINT91IEEDSFSSLG
101-150101SLEHLDLSYN111YLSNLSSSWF121KPLSSLTFLN131LLGNPYKTLG141ETSLFSHLTK
151-200151LQILRVGNMD161TFTKIQRKDF171AGLTFLEELE181IDASDLQSYE191PKSLKSIQNV
201-250201SHLILHMKQH211ILLLEIFVDV221TSSVECLELR231DTDLDTFHFS241ELSTGETNSL
251-300251IKKFTFRNVK261ITDESLFQVM271KLLNQISGLL281ELEFDDCTLN291GVGNFRASDN
301-350301DRVIDPGKVE311TLTIRRLHIP321RFYLFYDLST331LYSLTERVKR341ITVENSKVFL
351-400351VPCLLSQHLK361SLEYLDLSEN371LMVEEYLKNS381ACEDAWPSLQ391TLILRQNHLA
401-450401SLEKTGETLL411TLKNLTNIDI421SKNSFHSMPE431TCQWPEKMKY441LNLSSTRIHS
451-500451VTGCIPKTLE461ILDVSNNNLN471LFSLNLPQLK481ELYISRNKLM491TLPDASLLPM
501-550501LLVLKISRNA511ITTFSKEQLD521SFHTLKTLEA531GGNNFICSCE541FLSFTQEQQA
551-600551LAKVLIDWPA561NYLCDSPSHV571RGQQVQDVRL581SVSECHRTAL591VSGMCCALFL
601-650601LILLTGVLCH611RFHGLWYMKM621MWAWLQAKRK631PRKAPSRNIC641YDAFVSYSER
651-700651DAYWVENLMV661QELENFNPPF671KLCLHKRDFI681PGKWIIDNII691DSIEKSHKTV
701-750701FVLSENFVKS711EWCKYELDFS721HFRLFDENND731AAILILLEPI741EKKAIPQRFC
751-784751KLRKIMNTKT761YLEWPMDEAQ771REGFWVNLRA781AIKS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 30 | - | - | - |
Deep-Palm: 0.89
|
|
| 36 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.90
|
|
| 75 | - | - | - |
Deep-Palm: 0.62
|
|
| 226 | - | - | - |
Deep-Palm: 0.86
|
|
| 287 | - | - | - |
Deep-Palm: 0.93
|
|
| 353 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.90
|
|
| 382 | - | - | - |
Deep-Palm: 0.74
|
|
| 432 | - | - | - |
Deep-Palm: 0.06
|
|
| 454 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.79
|
|
| 537 | - | - | - |
Deep-Palm: 0.71
|
|
| 539 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.80
|
|
| 564 | - | - | - |
Deep-Palm: 0.81
|
|
| 585 | - | - | - |
Deep-Palm: 0.87
|
|
| 595 | - | - | - |
Deep-Palm: 0.96
|
|
| 596 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.97
|
|
| 609 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.55
|
| 640 | - | - | - |
Deep-Palm: 0.76
|
|
| 673 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.66
|
|
| 713 | - | - | - |
Deep-Palm: 0.32
|
|
| 750 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.86
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
heart
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 95 | S → C | 0.010870 | SNP | Missense Mutation | ACC |
| 146 | S → C | 0.002545 | SNP | Missense Mutation | GBM |
| 385 | A → Cfs*2 | 0.002033 | INS | Nonsense Mutation | THCA |
| 454 | C → R | 0.002288 | SNP | Missense Mutation | STAD |
| 465 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 473 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 611 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |