Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O60603 TLR2; TIL4 Toll-like receptor 2 (Toll/interleukin-1 receptor-like … Homo sapiens (Human) 784 aa

Protein Details: O60603 (TLR2)

Protein Information
Accession O60603
Protein Names Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene Symbol TLR2; TIL4
Organism Homo sapiens (Human)
Length 784 aa
Isoforms No isoforms
Related PMIDs 32944167 33636221
Database Sources dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
4
PC3 cells
Specificity: 0.800
4/4 (100.0%)
1
Liver membrane
Specificity: 0.200
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MPHTLWMVWV11LGVIISLSKE21ESSNQASLSC31DRNGICKGSS41GSLNSIPSGL
51-10051TEAVKSLDLS61NNRITYISNS71DLQRCVNLQA81LVLTSNGINT91IEEDSFSSLG
101-150101SLEHLDLSYN111YLSNLSSSWF121KPLSSLTFLN131LLGNPYKTLG141ETSLFSHLTK
151-200151LQILRVGNMD161TFTKIQRKDF171AGLTFLEELE181IDASDLQSYE191PKSLKSIQNV
201-250201SHLILHMKQH211ILLLEIFVDV221TSSVECLELR231DTDLDTFHFS241ELSTGETNSL
251-300251IKKFTFRNVK261ITDESLFQVM271KLLNQISGLL281ELEFDDCTLN291GVGNFRASDN
301-350301DRVIDPGKVE311TLTIRRLHIP321RFYLFYDLST331LYSLTERVKR341ITVENSKVFL
351-400351VPCLLSQHLK361SLEYLDLSEN371LMVEEYLKNS381ACEDAWPSLQ391TLILRQNHLA
401-450401SLEKTGETLL411TLKNLTNIDI421SKNSFHSMPE431TCQWPEKMKY441LNLSSTRIHS
451-500451VTGCIPKTLE461ILDVSNNNLN471LFSLNLPQLK481ELYISRNKLM491TLPDASLLPM
501-550501LLVLKISRNA511ITTFSKEQLD521SFHTLKTLEA531GGNNFICSCE541FLSFTQEQQA
551-600551LAKVLIDWPA561NYLCDSPSHV571RGQQVQDVRL581SVSECHRTAL591VSGMCCALFL
601-650601LILLTGVLCH611RFHGLWYMKM621MWAWLQAKRK631PRKAPSRNIC641YDAFVSYSER
651-700651DAYWVENLMV661QELENFNPPF671KLCLHKRDFI681PGKWIIDNII691DSIEKSHKTV
701-750701FVLSENFVKS711EWCKYELDFS721HFRLFDENND731AAILILLEPI741EKKAIPQRFC
751-784751KLRKIMNTKT761YLEWPMDEAQ771REGFWVNLRA781AIKS
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
36 Prediction (Low) - -
353 Prediction (Medium) - -
454 Prediction (High) - -
539 Prediction (Low) - -
596 Prediction (Low) - -
609 DBPTM SWISSPALM Prediction (Medium) - -
673 Prediction (Medium) - -
750 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
95 S → C 0.010870 SNP Missense Mutation ACC
146 S → C 0.002545 SNP Missense Mutation GBM
385 A → Cfs*2 0.002033 INS Nonsense Mutation THCA
454 C → R 0.002288 SNP Missense Mutation STAD
465 S → C 0.001764 SNP Missense Mutation LUAD
473 S → C 0.003460 SNP Missense Mutation CESC
611 R → C 0.001887 SNP Missense Mutation UCEC