Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O60810 PRAMEF4 PRAME family member 4 Homo sapiens (Human) 478 aa

Protein Details: O60810 (PRAMEF4)

Protein Information
AccessionO60810
Protein NamesPRAME family member 4
Gene SymbolPRAMEF4
OrganismHomo sapiens (Human)
Length478 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MKMSIWTPPR11LLELAGRSLL21RDQALAMSTL31EELPTELFPP41LFMEAFSRRR
51-10051CEALKLMVQS61WPFRRLPLRP71LIKMPCLEAF81QAVLDGLDAL91LNLGVRPRRW
101-150101KLQVLDLQDV111CENFWMVWSE121AMAHGCFLNA131KRNKKPVEDC141PRMKGRQPLT
151-200151VFVELWLKNR161TLDEYLTCLL171LWVKQRKDLL181HLCCKKLKIL191GMPFRNIRSI
201-250201LKMVNLDCIQ211EVEVNCKWVL221PILTQFTPYL231GHMRNLQKLI241LSHMDVSRYV
251-300251SPEQKKEIVT261QFTTQFLKLR271CLQKLYMNSV281SFLEGHLDQL291LSCLKTSLKF
301-350301LTITNCVLLE311SDLKHLSQCP321SISQLKTLDL331SGIRLTNYSL341VPLQILLEKV
351-400351AATLEYLDLD361DCGIIDSQVN371AILPALSRCF381ELNTFSFCGN391PICMATLENL
401-450401LSHTIILKNL411CVELYPAPRE421SYGADGTLCW431SRFAQIRAEL441MNRVRDLRHP
451-478451KRILFCTDYC461PDCGNRSFYD471LEADQYCC
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
51 - - -
GPS-Palm: 0.81
Deep-Palm: 0.93
76 - - -
GPS-Palm: 0.88
Deep-Palm: 0.98
111 - - -
Deep-Palm: 0.24
126 - - -
GPS-Palm: 0.86
Deep-Palm: 0.11
140 - - -
GPS-Palm: 0.91
Deep-Palm: 0.84
168 - - -
GPS-Palm: 0.93
Deep-Palm: 0.96
183 SWISSPALM DBPTM CYSMODDB - - -
GPS-Palm: 0.92
Deep-Palm: 0.89
184 SWISSPALM DBPTM CYSMODDB - - -
GPS-Palm: 0.84
Deep-Palm: 0.94
208 - - -
GPS-Palm: 0.84
Deep-Palm: 0.83
216 - - -
GPS-Palm: 0.66
Deep-Palm: 0.63
271 - - -
GPS-Palm: 0.78
Deep-Palm: 0.78
293 - - -
GPS-Palm: 0.76
Deep-Palm: 0.97
306 - - -
GPS-Palm: 0.86
Deep-Palm: 0.94
319 - - -
GPS-Palm: 0.69
Deep-Palm: 0.95
362 - - -
Deep-Palm: 0.95
379 - - -
Deep-Palm: 0.51
388 - - -
Deep-Palm: 0.78
393 - - -
Deep-Palm: 0.45
411 - - -
GPS-Palm: 0.74
Deep-Palm: 0.92
429 - - -
GPS-Palm: 0.78
Deep-Palm: 0.96
456 - - -
GPS-Palm: 0.87
Deep-Palm: 0.08
460 - - -
GPS-Palm: 0.65
Deep-Palm: 0.08
463 - - -
Deep-Palm: 0.02
477 - - -
GPS-Palm: 0.95
Deep-Palm: 0.02
478 - - -
GPS-Palm: 0.97
Deep-Palm: 0.01
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
42 F → C 0.005435 SNP Missense Mutation ESCA
50 R → C 0.005618 SNP Missense Mutation PAAD
65 R → C 0.027027 SNP Missense Mutation DLBC
96 R → C 0.010707 SNP Missense Mutation SKCM
140 C → S 0.002747 SNP Missense Mutation LIHC
168 C → S 0.001764 SNP Missense Mutation LUAD
216 C → R 0.002141 SNP Missense Mutation SKCM
248 R → C 0.002141 SNP Missense Mutation SKCM
306 C → R 0.002288 SNP Missense Mutation STAD
319 C → Y 0.002506 SNP Missense Mutation COAD
338 Y → C 0.001887 SNP Missense Mutation UCEC
377 S → C 0.001764 SNP Missense Mutation LUAD
478 C → S 0.002545 SNP Missense Mutation GBM
429* C → ? 0.001969 SNP Nonsense Mutation HNSC