Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O75131 | CPNE3 | Copine-3 (Copine III) | Homo sapiens (Human) | 537 aa |
Protein Details: O75131 (CPNE3)
Protein Information
| Accession | O75131 |
|---|---|
| Protein Names | Copine-3 (Copine III) |
| Gene Symbol | CPNE3 |
| Organism | Homo sapiens (Human) |
| Length | 537 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAQCVTKVA11LNVSCANLLD21KDIGSKSDPL31CVLFLNTSGQ41QWYEVERTER
51-10051IKNCLNPQFS61KTFIIDYYFE71VVQKLKFGVY81DIDNKTIELS91DDDFLGECEC
101-150101TLGQIVSSKK111LTRPLVMKTG121RPAGKGSITI131SAEEIKDNRV141VLFEMEARKL
151-200151DNKDLFGKSD161PYLEFHKQTS171DGNWLMVHRT181EVVKNNLNPV191WRPFKISLNS
201-250201LCYGDMDKTI211KVECYDYDND221GSHDLIGTFQ231TTMTKLKEAS241RSSPVEFECI
251-300251NEKKRQKKKS261YKNSGVISVK271QCEITVECTF281LDYIMGGCQL291NFTVGVDFTG
301-350301SNGDPRSPDS311LHYISPNGVN321EYLTALWSVG331LVIQDYDADK341MFPAFGFGAQ
351-400351IPPQWQVSHE361FPMNFNPSNP371YCNGIQGIVE381AYRSCLPQIK391LYGPTNFSPI
401-450401INHVARFAAA411ATQQQTASQY421FVLLIITDGV431ITDLDETRQA441IVNASRLPMS
451-500451IIIVGVGGAD461FSAMEFLDGD471GGSLRSPLGE481VAIRDIVQFV491PFRQFQNAPK
501-537501EALAQCVLAE511IPQQVVGYFN521TYKLLPPKNP531ATKQQKQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 5 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.02
|
|
| 15 | - |
HeLa
(37611173)
|
Unknown
(32651440)
|
GPS-Palm: 0.84
Deep-Palm: 0.90
|
|
| 31 | C2 domain superfamily Copine |
HeLa
(37611173)
| - |
GPS-Palm: 0.74
Deep-Palm: 0.75
|
|
| 54 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.05
|
|
| 98 | - | - | - |
Deep-Palm: 0.26
|
|
| 100 | - | - | - |
Deep-Palm: 0.27
|
|
| 202 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.27
|
|
| 214 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.03
|
|
| 249 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.83
Deep-Palm: 0.92
|
|
| 272 | - | - | - |
Deep-Palm: 0.23
|
|
| 278 | - | - | - |
Deep-Palm: 0.09
|
|
| 288 | - | - | - |
Deep-Palm: 0.09
|
|
| 372 | - | - | - |
Deep-Palm: 0.08
|
|
| 385 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.67
|
|
| 506 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.88
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
3
LNCaP
Specificity: 0.273
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.273
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.091
1/1 (100.0%)
1
293T cell
Specificity: 0.091
1/1 (100.0%)
1
heart
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.182
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 54 | C → F | 0.002033 | SNP | Missense Mutation | LUSC |
| 54 | C → S | 0.002033 | SNP | Missense Mutation | LUSC |
| 288 | C → C | 0.002506 | SNP | Silent | COAD |
| 336 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 392 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |