Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O75326 | SEMA7A | Semaphorin-7A (CDw108) (JMH blood group … | Homo sapiens (Human) | 666 aa |
Protein Details: O75326 (SEMA7A)
Protein Information
| Accession | O75326 |
|---|---|
| Protein Names | Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108) |
| Gene Symbol | SEMA7A |
| Organism | Homo sapiens (Human) |
| Length | 666 aa |
| Isoforms | No isoforms |
| Related PMIDs | 25914232 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTPPPPGRAA11PSAPRARVPG21PPARLGLPLR31LRLLLLLWAA41AASAQGHLRS
51-10051GPRIFAVWKG61HVGQDRVDFG71QTEPHTVLFH81EPGSSSVWVG91GRGKVYLFDF
101-150101PEGKNASVRT111VNIGSTKGSC121LDKRDCENYI131TLLERRSEGL141LACGTNARHP
151-200151SCWNLVNGTV161VPLGEMRGYA171PFSPDENSLV181LFEGDEVYST191IRKQEYNGKI
201-250201PRFRRIRGES211ELYTSDTVMQ221NPQFIKATIV231HQDQAYDDKI241YYFFREDNPD
251-300251KNPEAPLNVS261RVAQLCRGDQ271GGESSLSVSK281WNTFLKAMLV291CSDAATNKNF
301-350301NRLQDVFLLP311DPSGQWRDTR321VYGVFSNPWN331YSAVCVYSLG341DIDKVFRTSS
351-400351LKGYHSSLPN361PRPGKCLPDQ371QPIPTETFQV381ADRHPEVAQR391VEPMGPLKTP
401-450401LFHSKYHYQK411VAVHRMQASH421GETFHVLYLT431TDRGTIHKVV441EPGEQEHSFA
451-500451FNIMEIQPFR461RAAAIQTMSL471DAERRKLYVS481SQWEVSQVPL491DLCEVYGGGC
501-550501HGCLMSRDPY511CGWDQGRCIS521IYSSERSVLQ531SINPAEPHKE541CPNPKPDKAP
551-600551LQKVSLAPNS561RYYLSCPMES571RHATYSWRHK581ENVEQSCEPG591HQSPNCILFI
601-650601ENLTAQQYGH611YFCEAQEGSY621FREAQHWQLL631PEDGIMAEHL641LGHACALAAS
651-666651LWLGVLPTLT661LGLLVH
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 120 | - | - | - |
Deep-Palm: 0.81
|
|
| 126 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.94
|
|
| 143 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.67
|
|
| 152 | - | - | - |
Deep-Palm: 0.66
|
|
| 266 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.95
|
|
| 291 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.80
|
|
| 335 | - | - | - |
Deep-Palm: 0.11
|
|
| 366 | - | - | - |
Deep-Palm: 0.56
|
|
| 493 | - | - | - |
Deep-Palm: 0.26
|
|
| 500 | - | - | - |
Deep-Palm: 0.06
|
|
| 503 | - | - | - |
Deep-Palm: 0.04
|
|
| 511 | - | - | - |
Deep-Palm: 0.03
|
|
| 518 | - | - | - |
Deep-Palm: 0.09
|
|
| 541 | - | - | - |
Deep-Palm: 0.73
|
|
| 566 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.60
|
|
| 587 | - | - | - |
Deep-Palm: 0.06
|
|
| 596 | - | - | - |
Deep-Palm: 0.05
|
|
| 613 | - | - | - |
Deep-Palm: 0.03
|
|
| 645 | - | - | - |
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
CEM 174 cell
Specificity: 1.000
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 204 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 266 | C → Y | 0.005618 | SNP | Missense Mutation | PAAD |
| 291 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 347 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 415 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 541 | C → G | 0.001764 | SNP | Missense Mutation | LUAD |
| 578 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 596 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 613 | C → C | 0.003774 | SNP | Silent | UCEC |
| 511* | C → ? | 0.002033 | SNP | Nonsense Mutation | LUSC |