Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O75390 | CS | Citrate synthase, mitochondrial (EC 2.3.3.1) … | Homo sapiens (Human) | 466 aa |
Protein Details: O75390 (CS)
Protein Information
| Accession | O75390 |
|---|---|
| Protein Names | Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) |
| Gene Symbol | CS |
| Organism | Homo sapiens (Human) |
| Length | 466 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 33636221 36430497 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.591
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
26
LNCaP cells
Specificity: 0.591
26/46 (56.5%)
6
HAP1 cells
Specificity: 0.136
6/10 (60.0%)
4
293T cells
Specificity: 0.091
4/10 (40.0%)
4
Cerebral cortex
Specificity: 0.091
4/4 (100.0%)
3
PC3 cells
Specificity: 0.068
3/4 (75.0%)
1
Liver membrane
Specificity: 0.023
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MALLTAAARL11LGTKNASCLV21LAARHASASS31TNLKDILADL41IPKEQARIKT
51-10051FRQQHGKTVV61GQITVDMMYG71GMRGMKGLVY81ETSVLDPDEG91IRFRGFSIPE
101-150101CQKLLPKAKG111GEEPLPEGLF121WLLVTGHIPT131EEQVSWLSKE141WAKRAALPSH
151-200151VVTMLDNFPT161NLHPMSQLSA171AVTALNSESN181FARAYAQGIS191RTKYWELIYE
201-250201DSMDLIAKLP211CVAAKIYRNL221YREGSGIGAI231DSNLDWSHNF241TNMLGYTDHQ
251-300251FTELTRLYLT261IHSDHEGGNV271SAHTSHLVGS281ALSDPYLSFA291AAMNGLAGPL
301-350301HGLANQEVLV311WLTQLQKEVG321KDVSDEKLRD331YIWNTLNSGR341VVPGYGHAVL
351-400351RKTDPRYTCQ361REFALKHLPN371DPMFKLVAQL381YKIVPNVLLE391QGKAKNPWPN
401-450401VDAHSGVLLQ411YYGMTEMNYY421TVLFGVSRAL431GVLAQLIWSR441ALGFPLERPK
451-466451SMSTEGLMKF461VDSKSG
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 18 | Prediction (High) | - | - |
| 101 | Prediction (High) | - | - |
| 211 | Prediction (Medium) | - | - |
| 359 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 92 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 166 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 256 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 256 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 279 | G → C | 0.002294 | SNP | Missense Mutation | OV |
| 420 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 439 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 443 | G → C | 0.002506 | SNP | Missense Mutation | COAD |