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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O75509 TNFRSF21; DR6; UNQ437/PRO868 Tumor necrosis factor receptor superfamily … Homo sapiens (Human) 655 aa

Protein Details: O75509 (TNFRSF21)

Protein Information
Accession O75509
Protein Names Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
Gene Symbol TNFRSF21; DR6; UNQ437/PRO868
Organism Homo sapiens (Human)
Length 655 aa
Isoforms No isoforms
Related PMIDs 32944167
Database Sources dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
3
PC3 cells
Specificity: 1.000
3/4 (75.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGTSPSSSTA11LASCSRIARR21ATATMIAGSL31LLLGFLSTTT41AQPEQKASNL
51-10051IGTYRHVDRA61TGQVLTCDKC71PAGTYVSEHC81TNTSLRVCSS91CPVGTFTRHE
101-150101NGIEKCHDCS111QPCPWPMIEK121LPCAALTDRE131CTCPPGMFQS141NATCAPHTVC
151-200151PVGWGVRKKG161TETEDVRCKQ171CARGTFSDVP181SSVMKCKAYT191DCLSQNLVVI
201-250201KPGTKETDNV211CGTLPSFSSS221TSPSPGTAIF231PRPEHMETHE241VPSSTYVPKG
251-300251MNSTESNSSA261SVRPKVLSSI271QEGTVPDNTS281SARGKEDVNK291TLPNLQVVNH
301-350301QQGPHHRHIL311KLLPSMEATG321GEKSSTPIKG331PKRGHPRQNL341HKHFDINEHL
351-400351PWMIVLFLLL361VLVVIVVCSI371RKSSRTLKKG381PRQDPSAIVE391KAGLKKSMTP
401-450401TQNREKWIYY411CNGHGIDILK421LVAAQVGSQW431KDIYQFLCNA441SEREVAAFSN
451-500451GYTADHERAY461AALQHWTIRG471PEASLAQLIS481ALRQHRRNDV491VEKIRGLMED
501-550501TTQLETDKLA511LPMSPSPLSP521SPIPSPNAKL531ENSALLTVEP541SPQDKNKGFF
551-600551VDESEPLLRC561DSTSSGSSAL571SRNGSFITKE581KKDTVLRQVR591LDPCDLQPIF
601-650601DDMLHFLNPE611ELRVIEEIPQ621AEDKLDRLFE631IIGVKSQEAS641QTLLDSVYSH
651-655651LPDLL
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
14 Prediction (High) - -
88 Prediction (Low) - -
91 Prediction (Medium) - -
123 Prediction (Low) - -
150 Prediction (Low) - -
192 Prediction (Medium) - -
368 DBPTM SWISSPALM Prediction (High) - -
411 Prediction (Low) - -
594 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
150 C → R 0.002288 SNP Missense Mutation STAD
186 C → F 0.002033 SNP Missense Mutation LUSC
368 C → C 0.002506 SNP Silent COAD
495 R → C 0.002506 SNP Missense Mutation COAD
590 R → C 0.002020 SNP Missense Mutation PRAD