Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O75581 | LRP6 | Low-density lipoprotein receptor-related protein 6 … | Homo sapiens (Human) | 1613 aa |
Protein Details: O75581 (LRP6)
Protein Information
| Accession | O75581 |
|---|---|
| Protein Names | Low-density lipoprotein receptor-related protein 6 (LRP-6) |
| Gene Symbol | LRP6 |
| Organism | Homo sapiens (Human) |
| Length | 1613 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGAVLRSLLA11CSFCVLLRAA21PLLLYANRRD31LRLVDATNGK41ENATIVVGGL
51-10051EDAAAVDFVF61SHGLIYWSDV71SEEAIKRTEF81NKTESVQNVV91VSGLLSPDGL
101-150101ACDWLGEKLY111WTDSETNRIE121VSNLDGSLRK131VLFWQELDQP141RAIALDPSSG
151-200151FMYWTDWGEV161PKIERAGMDG171SSRFIIINSE181IYWPNGLTLD191YEEQKLYWAD
201-250201AKLNFIHKSN211LDGTNRQAVV221KGSLPHPFAL231TLFEDILYWT241DWSTHSILAC
251-300251NKYTGEGLRE261IHSDIFSPMD271IHAFSQQRQP281NATNPCGIDN291GGCSHLCLMS
301-350301PVKPFYQCAC311PTGVKLLENG321KTCKDGATEL331LLLARRTDLR341RISLDTPDFT
351-400351DIVLQLEDIR361HAIAIDYDPV371EGYIYWTDDE381VRAIRRSFID391GSGSQFVVTA
401-450401QIAHPDGIAV411DWVARNLYWT421DTGTDRIEVT431RLNGTMRKIL441ISEDLEEPRA
451-500451IVLDPMVGYM461YWTDWGEIPK471IERAALDGSD481RVVLVNTSLG491WPNGLALDYD
501-550501EGKIYWGDAK511TDKIEVMNTD521GTGRRVLVED531KIPHIFGFTL541LGDYVYWTDW
551-600551QRRSIERVHK561RSAEREVIID571QLPDLMGLKA581TNVHRVIGSN591PCAEENGGCS
601-650601HLCLYRPQGL611RCACPIGFEL621ISDMKTCIVP631EAFLLFSRRA641DIRRISLETN
651-700651NNNVAIPLTG661VKEASALDFD671VTDNRIYWTD681ISLKTISRAF691MNGSALEHVV
701-750701EFGLDYPEGM711AVDWLGKNLY721WADTGTNRIE731VSKLDGQHRQ741VLVWKDLDSP
751-800751RALALDPAEG761FMYWTEWGGK771PKIDRAAMDG781SERTTLVPNV791GRANGLTIDY
801-850801AKRRLYWTDL811DTNLIESSNM821LGLNREVIAD831DLPHPFGLTQ841YQDYIYWTDW
851-900851SRRSIERANK861TSGQNRTIIQ871GHLDYVMDIL881VFHSSRQSGW891NECASSNGHC
901-950901SHLCLAVPVG911GFVCGCPAHY921SLNADNRTCS931APTTFLLFSQ941KSAINRMVID
951-1000951EQQSPDIILP961IHSLRNVRAI971DYDPLDKQLY981WIDSRQNMIR991KAQEDGSQGF
1001-10501001TVVVSSVPSQ1011NLEIQPYDLS1021IDIYSRYIYW1031TCEATNVINV1041TRLDGRSVGV
1051-11001051VLKGEQDRPR1061AVVVNPEKGY1071MYFTNLQERS1081PKIERAALDG1091TEREVLFFSG
1101-11501101LSKPIALALD1111SRLGKLFWAD1121SDLRRIESSD1131LSGANRIVLE1141DSNILQPVGL
1151-12001151TVFENWLYWI1161DKQQQMIEKI1171DMTGREGRTK1181VQARIAQLSD1191IHAVKELNLQ
1201-12501201EYRQHPCAQD1211NGGCSHICLV1221KGDGTTRCSC1231PMHLVLLQDE1241LSCGEPPTCS
1251-13001251PQQFTCFTGE1261IDCIPVAWRC1271DGFTECEDHS1281DELNCPVCSE1291SQFQCASGQC
1301-13501301IDGALRCNGD1311ANCQDKSDEK1321NCEVLCLIDQ1331FRCANGQCIG1341KHKKCDHNVD
1351-14001351CSDKSDELDC1361YPTEEPAPQA1371TNTVGSVIGV1381IVTIFVSGTV1391YFICQRMLCP
1401-14501401RMKGDGETMT1411NDYVVHGPAS1421VPLGYVPHPS1431SLSGSLPGMS1441RGKSMISSLS
1451-15001451IMGGSSGPPY1461DRAHVTGASS1471SSSSSTKGTY1481FPAILNPPPS1491PATERSHYTM
1501-15501501EFGYSSNSPS1511THRSYSYRPY1521SYRHFAPPTT1531PCSTDVCDSD1541YAPSRRMTSV
1551-16001551ATAKGYTSDL1561NYDSEPVPPP1571PTPRSQYLSA1581EENYESCPPS1591PYTERSYSHH
1601-16131601LYPPPPSPCT1611DSS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 11 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.54
|
|
| 14 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.98
|
|
| 102 | - | - | - |
Deep-Palm: 0.81
|
|
| 250 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.10
|
|
| 286 | - | - | - |
Deep-Palm: 0.03
|
|
| 293 | - | - | - |
Deep-Palm: 0.02
|
|
| 297 | - | - | - |
Deep-Palm: 0.02
|
|
| 308 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.37
|
|
| 310 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.59
|
|
| 323 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.97
|
|
| 592 | - | - | - |
Deep-Palm: 0.12
|
|
| 599 | - | - | - |
Deep-Palm: 0.14
|
|
| 603 | - | - | - |
Deep-Palm: 0.15
|
|
| 612 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.13
|
|
| 614 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.11
|
|
| 627 | - | - | - |
Deep-Palm: 0.45
|
|
| 893 | - | - | - |
Deep-Palm: 0.13
|
|
| 900 | - | - | - |
Deep-Palm: 0.05
|
|
| 904 | - | - | - |
Deep-Palm: 0.02
|
|
| 914 | - | - | - |
Deep-Palm: 0.04
|
|
| 916 | - | - | - |
Deep-Palm: 0.20
|
|
| 929 | - | - | - |
Deep-Palm: 0.30
|
|
| 1032 | - | - | - |
Deep-Palm: 0.17
|
|
| 1207 | - | - | - |
Deep-Palm: 0.24
|
|
| 1214 | - | - | - |
Deep-Palm: 0.07
|
|
| 1218 | - | - | - |
Deep-Palm: 0.02
|
|
| 1228 | - | - | - |
Deep-Palm: 0.10
|
|
| 1230 | - | - | - |
Deep-Palm: 0.30
|
|
| 1243 | - | - | - |
Deep-Palm: 0.06
|
|
| 1249 | - | - | - |
Deep-Palm: 0.23
|
|
| 1256 | - | - | - |
Deep-Palm: 0.04
|
|
| 1263 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.03
|
|
| 1270 | - | - | - |
Deep-Palm: 0.02
|
|
| 1276 | - | - | - |
Deep-Palm: 0.02
|
|
| 1285 | - | - | - |
Deep-Palm: 0.02
|
|
| 1288 | - | - | - |
Deep-Palm: 0.02
|
|
| 1295 | - | - | - |
Deep-Palm: 0.08
|
|
| 1300 | - | - | - |
Deep-Palm: 0.13
|
|
| 1307 | - | - | - |
Deep-Palm: 0.05
|
|
| 1313 | - | - | - |
Deep-Palm: 0.04
|
|
| 1322 | - | - | - |
Deep-Palm: 0.03
|
|
| 1326 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.06
|
|
| 1333 | - | - | - |
Deep-Palm: 0.03
|
|
| 1338 | - | - | - |
Deep-Palm: 0.03
|
|
| 1345 | - | - | - |
Deep-Palm: 0.03
|
|
| 1351 | - | - | - |
Deep-Palm: 0.03
|
|
| 1360 | - | - | - |
Deep-Palm: 0.09
|
|
| 1394 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.57
|
| 1399 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.19
|
| 1532 | - | - | - |
Deep-Palm: 0.08
|
|
| 1537 | - | - | - |
Deep-Palm: 0.18
|
|
| 1587 | - | - | - |
Deep-Palm: 0.17
|
|
| 1609 | - | - | - |
Deep-Palm: 0.01
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 66 | Y → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 165 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 259 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 341 | R → _I342insCPIK | 0.002033 | INS | In Frame Ins | THCA |
| 385 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 386 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 386 | R → C | 0.017544 | SNP | Missense Mutation | UCS |
| 481 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 505 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 603 | C → Sfs*12 | 0.002294 | DEL | Frame Shift Del | OV |
| 611 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 636 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 904 | C → C | 0.002141 | SNP | Silent | SKCM |
| 1007 | V → delinsGRDQGCC*TSYNI | 0.001887 | INS | Nonsense Mutation | UCEC |
| 1026 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1026 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 1027 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1256 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 1270 | C → C | 0.005618 | SNP | Silent | PAAD |
| 1288 | C → C | 0.002545 | SNP | Silent | GBM |
| 1447 | S → C | 0.002141 | SNP | Missense Mutation | SKCM |