Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O75600-2 | GCAT | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial … | Homo sapiens (Human) | 445 aa |
Protein Details: O75600-2 (GCAT)
Protein Information
| Accession | O75600-2 |
|---|---|
| Protein Names | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (AKB ligase) (EC 2.3.1.29) (Aminoacetone synthase) (Glycine acetyltransferase) |
| Gene Symbol | GCAT |
| Organism | Homo sapiens (Human) |
| Length | 445 aa |
| Isoforms | |
| Related PMIDs | 31251020 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MWPGNAWRAA11LFWVPRGRRA21QSALAQLRGI31LEGELEGIRG41AGTWKSERVI
51-10051TSRQGPHIRV61DGVSGGPGTV71IFPGLPLPHL81SCCIHLLSFT91SGILNFCANN
101-150101YLGLSSHPEV111IQAGLQALEE121FGAGLSSVRF131ICGTQSIHKN141LEAKIARFHQ
151-200151REDAILYPSC161YDANAGLFEA171LLTPEDAVLS181DELNHASIID191GIRLCKAHKY
201-250201RYRHLDMADL211EAKLQEAQKH221RLRLVATDGA231FSMDGDIAPL241QEICCLASRY
251-300251GALVFMDECH261ATGFLGPTGR271GTDELLGVMD281QVTIINSTLG291KALGGASGGY
301-350301TTGPGPLVSL311LRQRARPYLF321SNSLPPAVVG331CASKALDLLM341GSNTIVQSMA
351-400351AKTQRFRSKM361EAAGFTISGA371SHPICPVMLG381DARLASRMAD391DMLKRGIFVI
401-445401GFSYPVVPKG411KARIRVQISA421VHSEEDIDRC431VEAFVEVGRL441HGALP
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 71 | - | - | - |
Deep-Palm: 0.94
|
|
| 106 | - | - | - |
Deep-Palm: 0.97
|
|
| 132 | - | - | - |
GPS-Palm: 0.93
|
|
| 134 | - | - | - |
Deep-Palm: 0.66
|
|
| 169 | - | - | - |
Deep-Palm: 0.52
|
|
| 218 | - | - | - |
Deep-Palm: 0.93
|
|
| 219 | - | - | - |
Deep-Palm: 0.82
|
|
| 233 | - | - | - |
Deep-Palm: 0.93
|
|
| 305 | - | - | - |
Deep-Palm: 0.96
|
|
| 349 | - | - | - |
Deep-Palm: 0.97
|
|
| 404 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP
Specificity: 1.000
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 177 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 233 | C → Mfs*16 | 0.002033 | INS | Frame Shift Ins | THCA |
| 354 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |