Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O75716 | STK16; MPSK1; PKL12; TSF1 | Serine/threonine-protein kinase 16 (EC 2.7.11.1) … | Homo sapiens (Human) | 305 aa |
Protein Details: O75716 (STK16)
Protein Information
| Accession | O75716 |
|---|---|
| Protein Names | Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK) |
| Gene Symbol | STK16; MPSK1; PKL12; TSF1 |
| Organism | Homo sapiens (Human) |
| Length | 305 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 31251020 32944167 |
| Database Sources | dbPTM |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.875
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
35
LNCaP cells
Specificity: 0.875
35/46 (76.1%)
4
T cells
Specificity: 0.100
4/4 (100.0%)
1
PC3 cells
Specificity: 0.025
1/4 (25.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGHALCVCSR11GTVIIDNKRY21LFIQKLGEGG31FSYVDLVEGL41HDGHFYALKR
51-10051ILCHEQQDRE61EAQREADMHR71LFNHPNILRL81VAYCLRERGA91KHEAWLLLPF
101-150101FKRGTLWNEI111ERLKDKGNFL121TEDQILWLLL131GICRGLEAIH141AKGYAHRDLK
151-200151PTNILLGDEG161QPVLMDLGSM171NQACIHVEGS181RQALTLQDWA191AQRCTISYRA
201-250201PELFSVQSHC211VIDERTDVWS221LGCVLYAMMF231GEGPYDMVFQ241KGDSVALAVQ
251-300251NQLSIPQSPR261HSSALRQLLN271SMMTVDPHQR281PHIPLLLSQL291EALQPPAPGQ
301-305301HTTQI
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 6 | DBPTM Prediction (High) | - | - |
| 8 | DBPTM Prediction (High) | - | - |
| 53 | Prediction (Medium) | - | - |
| 84 | Prediction (High) | - | - |
| 133 | Prediction (Medium) | - | - |
| 174 | Prediction (Low) | - | - |
| 194 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 19 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 79 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 143 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 194 | C → R | 0.002020 | SNP | Missense Mutation | PRAD |
| 223 | C → C | 0.001887 | SNP | Silent | UCEC |
| 280 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |