Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O75828 | CBR3 | Carbonyl reductase [NADPH] 3 (EC … | Homo sapiens (Human) | 277 aa |
Protein Details: O75828 (CBR3)
Protein Information
| Accession | O75828 |
|---|---|
| Protein Names | Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2) |
| Gene Symbol | CBR3 |
| Organism | Homo sapiens (Human) |
| Length | 277 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 31251020 36430497 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSSCSRVALV11TGANRGIGLA21IARELCRQFS31GDVVLTARDV41ARGQAAVQQL
51-10051QAEGLSPRFH61QLDIDDLQSI71RALRDFLRKE81YGGLNVLVNN91AAVAFKSDDP
101-150101MPFDIKAEMT111LKTNFFATRN121MCNELLPIMK131PHGRVVNISS141LQCLRAFENC
151-200151SEDLQERFHS161ETLTEGDLVD171LMKKFVEDTK181NEVHEREGWP191NSPYGVSKLG
201-250201VTVLSRILAR211RLDEKRKADR221ILVNACCPGP231VKTDMDGKDS241IRTVEEGAET
251-277251PVYLALLPPD261ATEPQGQLVH271DKVVQNW
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 4 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.10
|
|
| 26 | CARBONYL REDUCTASE 1-RELATED NAD(P)-binding domain superfamily Short-chain dehydrogenase/reductase SDR | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.98
|
|
| 122 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.93
|
|
| 143 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.89
|
|
| 150 | - | - | - |
Deep-Palm: 0.80
|
|
| 226 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.97
|
|
| 227 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
1
LNCaP
Specificity: 0.333
1/1 (100.0%)
1
cerebral cortex
Specificity: 0.333
1/1 (100.0%)
1
HUVECs
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 158 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 226 | C → G | 0.002141 | SNP | Missense Mutation | SKCM |