Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O88703 Hcn2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel … Mus musculus (Mouse) 863 aa

Protein Details: O88703 (Hcn2)

Protein Information
AccessionO88703
Protein NamesPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1)
Gene SymbolHcn2
OrganismMus musculus (Mouse)
Length863 aa
IsoformsNo isoforms
Related PMIDs 29733200 34200797 35358180 29217618 (mass) 31311849 (mass) 31772009 (mass) 34884899 (mass) 35358180 (mass) 37925639 (mass)
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MDARGGGGRP11GDSPGTTPAP21GPPPPPPPPA31PPQPQPPPAP41PPNPTTPSHP
51-10051ESADEPGPRA61RLCSRDSACT71PGAAKGGANG81ECGRGEPQCS91PEGPARGPKV
101-150101SFSCRGAASG111PSAAEEAGSE121EAGPAGEPRG131SQASFLQRQF141GALLQPGVNK
151-200151FSLRMFGSQK161AVEREQERVK171SAGAWIIHPY181SDFRFYWDFT191MLLFMVGNLI
201-250201IIPVGITFFK211DETTAPWIVF221NVVSDTFFLM231DLVLNFRTGI241VIEDNTEIIL
251-300251DPEKIKKKYL261RTWFVVDFVS271SIPVDYIFLI281VEKGIDSEVY291KTARALRIVR
301-350301FTKILSLLRL311LRLSRLIRYI321HQWEEIFHMT331YDLASAVMRI341CNLISMMLLL
351-400351CHWDGCLQFL361VPMLQDFPSD371CWVSINNMVN381HSWSELYSFA391LFKAMSHMLC
401-450401IGYGRQAPES411MTDIWLTMLS421MIVGATCYAM431FIGHATALIQ441SLDSSRRQYQ
451-500451EKYKQVEQYM461SFHKLPADFR471QKIHDYYEHR481YQGKMFDEDS491ILGELNGPLR
501-550501EEIVNFNCRK511LVASMPLFAN521ADPNFVTAML531TKLKFEVFQP541GDYIIREGTI
551-600551GKKMYFIQHG561VVSVLTKGNK571EMKLSDGSYF581GEICLLTRGR591RTASVRADTY
601-650601CRLYSLSVDN611FNEVLEEYPM621MRRAFETVAI631DRLDRIGKKN641SILLHKVQHD
651-700651LSSGVFNNQE661NAIIQEIVKY671DREMVQQAEL681GQRVGLFPPP691PPPQVTSAIA
701-750701TLQQAVAMSF711CPQVARPLVG721PLALGSPRLV731RRAPPGPLPP741AASPGPPAAS
751-800751PPAAPSSPRA761PRTSPYGVPG771SPATRVGPAL781PARRLSRASR791PLSASQPSLP
801-850801HGVPAPSPAA811SARPASSSTP821RLGPAPTART831AAPSPDRRDS841ASPGAASGLD
851-863851PLDSARSRLS861SNL
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
63 DBPTM SWISSPALM - - -
Deep-Palm: 0.90
69 DBPTM SWISSPALM - - -
GPS-Palm: 0.83
Deep-Palm: 0.91
82 DBPTM SWISSPALM - - -
GPS-Palm: 0.66
Deep-Palm: 0.85
89 DBPTM SWISSPALM - - -
Deep-Palm: 0.86
104 DBPTM SWISSPALM - - -
GPS-Palm: 0.70
Deep-Palm: 0.97
341 - - -
GPS-Palm: 0.67
Deep-Palm: 0.03
351 - - -
Deep-Palm: 0.06
356 - - -
Deep-Palm: 0.04
371 - - -
Deep-Palm: 0.03
400 - - -
GPS-Palm: 0.92
Deep-Palm: 0.45
427 - - -
Deep-Palm: 0.13
508 - - -
GPS-Palm: 0.82
Deep-Palm: 0.95
584 - -
Brain (35358180)
GPS-Palm: 0.92
Deep-Palm: 0.94
601 - - -
Deep-Palm: 0.95
711 - - -
GPS-Palm: 0.87
Deep-Palm: 0.96
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Brain
Specificity: 0.400
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
6
Brain tissue (Mass)
Specificity: 0.600
6/56 (10.7%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine