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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O94923 GLCE; KIAA0836 D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan … Homo sapiens (Human) 617 aa

Protein Details: O94923 (GLCE)

Protein Information
Accession O94923
Protein Names D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase)
Gene Symbol GLCE; KIAA0836
Organism Homo sapiens (Human)
Length 617 aa
Isoforms No isoforms
Related PMIDs 24357059 31251020 32944167 33636221
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.895
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
34
LNCaP cells
Specificity: 0.895
34/46 (73.9%)
2
PC3 cells
Specificity: 0.053
2/4 (50.0%)
1
Endothelial cells
Specificity: 0.026
1/2 (50.0%)
1
Liver membrane
Specificity: 0.026
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MRCLAARVNY11KTLIIICALF21TLVTVLLWNK31CSSDKAIQFP41RRSSSGFRVD
51-10051GFEKRAAASE61SNNYMNHVAK71QQSEEAFPQE81QQKAPPVVGG91FNSNVGSKVL
101-150101GLKYEEIDCL111INDEHTIKGR121REGNEVFLPF131TWVEKYFDVY141GKVVQYDGYD
151-200151RFEFSHSYSK161VYAQRAPYHP171DGVFMSFEGY181NVEVRDRVKC191ISGVEGVPLS
201-250201TQWGPQGYFY211PIQIAQYGLS221HYSKNLTEKP231PHIEVYETAE241DRDKNKPNDW
251-300251TVPKGCFMAN261VADKSRFTNV271KQFIAPETSE281GVSLQLGNTK291DFIISFDLKF
301-350301LTNGSVSVVL311ETTEKNQLFT321IHYVSNAQLI331AFKERDIYYG341IGPRTSWSTV
351-400351TRDLVTDLRK361GVGLSNTKAV371KPTKIMPKKV381VRLIAKGKGF391LDNITISTTA
401-450401HMAAFFAASD411WLVRNQDEKG421GWPIMVTRKL431GEGFKSLEPG441WYSAMAQGQA
451-500451ISTLVRAYLL461TKDHIFLNSA471LRATAPYKFL481SEQHGVKAVF491MNKHDWYEEY
501-550501PTTPSSFVLN511GFMYSLIGLY521DLKETAGEKL531GKEARSLYER541GMESLKAMLP
551-600551LYDTGSGTIY561DLRHFMLGIA571PNLARWDYHT581THINQLQLLS591TIDESPVFKE
601-617601FVKRWKSYLK611GSRAKHN
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
3 Prediction (High) - -
17 Prediction (Low) - -
31 Prediction (Medium) - -
256 Prediction (Medium) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
146 Y → C 0.001969 SNP Missense Mutation HNSC
250 W → C 0.017544 SNP Missense Mutation UCS
481 S → C 0.002976 SNP Missense Mutation KIRC
512 F → C 0.002506 SNP Missense Mutation COAD
540 R → C 0.002288 SNP Missense Mutation STAD
540 R → C 0.001887 SNP Missense Mutation UCEC
563 R → C 0.002141 SNP Missense Mutation SKCM
575 R → C 0.004219 SNP Missense Mutation SARC
? ? → ? 0.002288 SNP Missense Mutation STAD
? ? → ? 0.002033 SNP Missense Mutation LUSC
? ? → ? 0.001887 SNP Missense Mutation UCEC