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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O94923 GLCE D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan … Homo sapiens (Human) 617 aa

Protein Details: O94923 (GLCE)

Protein Information
AccessionO94923
Protein NamesD-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase)
Gene SymbolGLCE
OrganismHomo sapiens (Human)
Length617 aa
IsoformsNo isoforms
Related PMIDs 24357059 31251020 32944167 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MRCLAARVNY11KTLIIICALF21TLVTVLLWNK31CSSDKAIQFP41RRSSSGFRVD
51-10051GFEKRAAASE61SNNYMNHVAK71QQSEEAFPQE81QQKAPPVVGG91FNSNVGSKVL
101-150101GLKYEEIDCL111INDEHTIKGR121REGNEVFLPF131TWVEKYFDVY141GKVVQYDGYD
151-200151RFEFSHSYSK161VYAQRAPYHP171DGVFMSFEGY181NVEVRDRVKC191ISGVEGVPLS
201-250201TQWGPQGYFY211PIQIAQYGLS221HYSKNLTEKP231PHIEVYETAE241DRDKNKPNDW
251-300251TVPKGCFMAN261VADKSRFTNV271KQFIAPETSE281GVSLQLGNTK291DFIISFDLKF
301-350301LTNGSVSVVL311ETTEKNQLFT321IHYVSNAQLI331AFKERDIYYG341IGPRTSWSTV
351-400351TRDLVTDLRK361GVGLSNTKAV371KPTKIMPKKV381VRLIAKGKGF391LDNITISTTA
401-450401HMAAFFAASD411WLVRNQDEKG421GWPIMVTRKL431GEGFKSLEPG441WYSAMAQGQA
451-500451ISTLVRAYLL461TKDHIFLNSA471LRATAPYKFL481SEQHGVKAVF491MNKHDWYEEY
501-550501PTTPSSFVLN511GFMYSLIGLY521DLKETAGEKL531GKEARSLYER541GMESLKAMLP
551-600551LYDTGSGTIY561DLRHFMLGIA571PNLARWDYHT581THINQLQLLS591TIDESPVFKE
601-617601FVKRWKSYLK611GSRAKHN
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
3 - - -
GPS-Palm: 0.93
Deep-Palm: 0.02
17 - - -
GPS-Palm: 0.77
Deep-Palm: 0.85
31 - - -
GPS-Palm: 0.86
Deep-Palm: 0.90
109 - - -
Deep-Palm: 0.94
190 - -
LNCaP (31251020)
Deep-Palm: 0.90
256 - - -
GPS-Palm: 0.84
Deep-Palm: 0.36
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
LNCaP
Specificity: 0.444
4/4 (100.0%)
2
PC3
Specificity: 0.222
2/2 (100.0%)
1
heart
Specificity: 0.111
1/1 (100.0%)
1
HUVECs
Specificity: 0.111
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.111
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
146 Y → C 0.001969 SNP Missense Mutation HNSC
250 W → C 0.017544 SNP Missense Mutation UCS
481 S → C 0.002976 SNP Missense Mutation KIRC
512 F → C 0.002506 SNP Missense Mutation COAD
540 R → C 0.002288 SNP Missense Mutation STAD
540 R → C 0.001887 SNP Missense Mutation UCEC
563 R → C 0.002141 SNP Missense Mutation SKCM
575 R → C 0.004219 SNP Missense Mutation SARC
? ? → ? 0.002288 SNP Missense Mutation STAD
? ? → ? 0.002033 SNP Missense Mutation LUSC
? ? → ? 0.001887 SNP Missense Mutation UCEC