Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O95336 | PGLS | 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) | Homo sapiens (Human) | 258 aa |
Protein Details: O95336 (PGLS)
Protein Information
| Accession | O95336 |
|---|---|
| Protein Names | 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) |
| Gene Symbol | PGLS |
| Organism | Homo sapiens (Human) |
| Length | 258 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 32944167 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAAPAPGLIS11VFSSSQELGA21ALAQLVAQRA31ACCLAGARAR41FALGLSGGSL
51-10051VSMLARELPA61AVAPAGPASL71ARWTLGFCDE81RLVPFDHAES91TYGLYRTHLL
101-150101SRLPIPESQV111ITINPELPVE121EAAEDYAKKL131RQAFQGDSIP141VFDLLILGVG
151-200151PDGHTCSLFP161DHPLLQEREK171IVAPISDSPK181PPPQRVTLTL191PVLNAARTVI
201-250201FVATGEGKAA211VLKRILEDQE221ENPLPAALVQ231PHTGKLCWFL241DEAAARLLTV
251-258251PFEKHSTL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 32 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.98
|
|
| 33 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.98
|
|
| 78 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.95
|
|
| 156 | - | - | - |
Deep-Palm: 0.97
|
|
| 237 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
PC3
Specificity: 0.750
3/3 (100.0%)
1
293T cell
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 69 | S → C | 0.002506 | SNP | Missense Mutation | COAD |
| 101 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 153 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 185 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 214 | R → C | 0.007299 | SNP | Missense Mutation | READ |