Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O95622 | ADCY5 | Adenylate cyclase type 5 (EC … | Homo sapiens (Human) | 1261 aa |
Protein Details: O95622 (ADCY5)
Protein Information
| Accession | O95622 |
|---|---|
| Protein Names | Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) |
| Gene Symbol | ADCY5 |
| Organism | Homo sapiens (Human) |
| Length | 1261 aa |
| Isoforms | No isoforms |
| Related PMIDs | 33636221 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSGSKSVSPP11GYAAQKTAAP21APRGGPEHRS31AWGEADSRAN41GYPHAPGGSA
51-10051RGSTKKPGGA61VTPQQQQRLA71SRWRSDDDDD81PPLSGDDPLA91GGFGFSFRSK
101-150101SAWQERGGDD111CGRGSRRQRR121GAASGGSTRA131PPAGGGGGSA141AAAASAGGTE
151-200151VRPRSVEVGL161EERRGKGRAA171DELEAGAVEG181GEGSGDGGSS191ADSGSGAGPG
201-250201AVLSLGACCL211ALLQIFRSKK221FPSDKLERLY231QRYFFRLNQS241SLTMLMAVLV
251-300251LVCLVMLAFH261AARPPLQLPY271LAVLAAAVGV281ILIMAVLCNR291AAFHQDHMGL
301-350301ACYALIAVVL311AVQVVGLLLP321QPRSASEGIW331WTVFFIYTIY341TLLPVRMRAA
351-400351VLSGVLLSAL361HLAIALRTNA371QDQFLLKQLV381SNVLIFSCTN391IVGVCTHYPA
401-450401EVSQRQAFQE411TRECIQARLH421SQRENQQQER431LLLSVLPRHV441AMEMKADINA
451-500451KQEDMMFHKI461YIQKHDNVSI471LFADIEGFTS481LASQCTAQEL491VMTLNELFAR
501-550501FDKLAAENHC511LRIKILGDCY521YCVSGLPEAR531ADHAHCCVEM541GMDMIEAISL
551-600551VREVTGVNVN561MRVGIHSGRV571HCGVLGLRKW581QFDVWSNDVT591LANHMEAGGK
601-650601AGRIHITKAT611LNYLNGDYEV621EPGCGGERNA631YLKEHSIETF641LILRCTQKRK
651-700651EEKAMIAKMN661RQRTNSIGHN671PPHWGAERPF681YNHLGGNQVS691KEMKRMGFED
701-750701PKDKNAQESA711NPEDEVDEFL721GRAIDARSID731RLRSEHVRKF741LLTFREPDLE
751-800751KKYSKQVDDR761FGAYVACASL771VFLFICFVQI781TIVPHSIFML791SFYLTCSLLL
801-850801TLVVFVSVIY811SCVKLFPSPL821QTLSRKIVRS831KMNSTLVGVF841TITLVFLAAF
851-900851VNMFTCNSRD861LLGCLAQEHN871ISASQVNACH881VAESAVNYSL891GDEQGFCGSP
901-950901WPNCNFPEYF911TYSVLLSLLA921CSVFLQISCI931GKLVLMLAIE941LIYVLIVEVP
951-1000951GVTLFDNADL961LVTANAIDFF971NNGTSQCPEH981ATKVALKVVT991PIIISVFVLA
1001-10501001LYLHAQQVES1011TARLDFLWKL1021QATEEKEEME1031ELQAYNRRLL1041HNILPKDVAA
1051-11001051HFLARERRND1061ELYYQSCECV1071AVMFASIANF1081SEFYVELEAN1091NEGVECLRLL
1101-11501101NEIIADFDEI1111ISEDRFRQLE1121KIKTIGSTYM1131AASGLNDSTY1141DKVGKTHIKA
1151-12001151LADFAMKLMD1161QMKYINEHSF1171NNFQMKIGLN1181IGPVVAGVIG1191ARKPQYDIWG
1201-12501201NTVNVASRMD1211STGVPDRIQV1221TTDMYQVLAA1231NTYQLECRGV1241VKVKGKGEMM
1251-12611251TYFLNGGPPL1261S
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 111 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.95
|
|
| 208 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.98
|
|
| 209 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
|
| 253 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.93
|
|
| 288 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.90
|
|
| 302 | - | - | - |
Deep-Palm: 0.50
|
|
| 388 | - | - | - |
Deep-Palm: 0.50
|
|
| 395 | - | - | - |
Deep-Palm: 0.25
|
|
| 414 | - | - | - |
Deep-Palm: 0.90
|
|
| 485 | - | - | - |
Deep-Palm: 0.75
|
|
| 510 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.66
|
|
| 519 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.61
|
|
| 522 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.76
Deep-Palm: 0.19
|
|
| 536 | - | - | - |
Deep-Palm: 0.07
|
|
| 537 | - | - | - |
Deep-Palm: 0.34
|
|
| 572 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.59
|
|
| 624 | - | - | - |
Deep-Palm: 0.76
|
|
| 645 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.89
|
|
| 767 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.27
|
|
| 776 | - | - | - |
Deep-Palm: 0.18
|
|
| 796 | - | - | - |
Deep-Palm: 0.52
|
|
| 812 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.97
|
|
| 856 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.69
|
|
| 864 | - | - | - |
Deep-Palm: 0.36
|
|
| 879 | - | - | - |
Deep-Palm: 0.44
|
|
| 897 | - | - | - |
Deep-Palm: 0.16
|
|
| 904 | - | - | - |
Deep-Palm: 0.75
|
|
| 921 | - | - | - |
Deep-Palm: 0.91
|
|
| 929 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.93
|
|
| 977 | - | - | - |
Deep-Palm: 0.72
|
|
| 1067 | - | - | - |
Deep-Palm: 0.11
|
|
| 1069 | - | - | - |
Deep-Palm: 0.05
|
|
| 1096 | - | - | - |
Deep-Palm: 0.78
|
|
| 1237 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.91
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
heart
Specificity: 0.333
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
Cerebral Cortex (Mass)
Specificity: 0.667
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 303 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 323 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 323 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 323 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 340 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 358 | S → C | 0.002294 | SNP | Missense Mutation | OV |
| 367 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 510 | C → C | 0.002033 | SNP | Silent | LUSC |
| 512 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 522 | C → C | 0.002506 | SNP | Silent | COAD |
| 522 | C → C | 0.005618 | SNP | Silent | PAAD |
| 537 | C → S | 0.002545 | SNP | Missense Mutation | GBM |
| 572 | C → C | 0.005618 | SNP | Silent | PAAD |
| 573 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 603 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 603 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 722 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 722 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 722 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 738 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 811 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 924 | F → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 1058 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 1058 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1208 | R → C | 0.002288 | SNP | Missense Mutation | STAD |