Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O95757 | HSPA4L; APG1; HSPH3; OSP94 | Heat shock 70 kDa protein … | Homo sapiens (Human) | 839 aa |
Protein Details: O95757 (HSPA4L)
Protein Information
| Accession | O95757 |
|---|---|
| Protein Names | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) |
| Gene Symbol | HSPA4L; APG1; HSPH3; OSP94 |
| Organism | Homo sapiens (Human) |
| Length | 839 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.528
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
19
LNCaP cells
Specificity: 0.528
19/46 (41.3%)
10
HAP1 cells
Specificity: 0.278
10/10 (100.0%)
4
293T cells
Specificity: 0.111
4/10 (40.0%)
3
Cerebral cortex
Specificity: 0.083
3/4 (75.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSVVGIDLGF11LNCYIAVARS21GGIETIANEY31SDRCTPACIS41LGSRTRAIGN
51-10051AAKSQIVTNV61RNTIHGFKKL71HGRSFDDPIV81QTERIRLPYE91LQKMPNGSAG
101-150101VKVRYLEEER111PFAIEQVTGM121LLAKLKETSE131NALKKPVADC141VISIPSFFTD
151-200151AERRSVMAAA161QVAGLNCLRL171MNETTAVALA181YGIYKQDLPP191LDEKPRNVVF
201-250201IDMGHSAYQV211LVCAFNKGKL221KVLATTFDPY231LGGRNFDEAL241VDYFCDEFKT
251-300251KYKINVKENS261RALLRLYQEC271EKLKKLMSAN281ASDLPLNIEC291FMNDLDVSSK
301-350301MNRAQFEQLC311ASLLARVEPP321LKAVMEQANL331QREDISSIEI341VGGATRIPAV
351-400351KEQITKFFLK361DISTTLNADE371AVARGCALQC381AILSPAFKVR391EFSITDLVPY
401-450401SITLRWKTSF411EDGSGECEVF421CKNHPAPFSK431VITFHKKEPF441ELEAFYTNLH
451-500451EVPYPDARIG461SFTIQNVFPQ471SDGDSSKVKV481KVRVNIHGIF491SVASASVIEK
501-550501QNLEGDHSDA511PMETETSFKN521ENKDNMDKMQ531VDQEEGHQKC541HAEHTPEEEI
551-600551DHTGAKTKSA561VSDKQDRLNQ571TLKKGKVKSI581DLPIQSSLCR591QLGQDLLNSY
601-650601IENEGKMIMQ611DKLEKERNDA621KNAVEEYVYD631FRDRLGTVYE641KFITPEDLSK
651-700651LSAVLEDTEN661WLYEDGEDQP671KQVYVDKLQE681LKKYGQPIQM691KYMEHEERPK
701-750701ALNDLGKKIQ711LVMKVIEAYR721NKDERYDHLD731PTEMEKVEKC741ISDAMSWLNS
751-800751KMNAQNKLSL761TQDPVVKVSE771IVAKSKELDN781FCNPIIYKPK791PKAEVPEDKP
801-839801KANSEHNGPM811DGQSGTETKS821DSTKDSSQHT831KSSGEMEVD
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 13 | Prediction (Low) | - | - |
| 34 | Prediction (Low) | - | - |
| 38 | Prediction (Low) | - | - |
| 140 | Prediction (Medium) | - | - |
| 167 | Prediction (High) | - | - |
| 213 | Prediction (Medium) | - | - |
| 245 | Prediction (Medium) | - | - |
| 270 | Prediction (Medium) | - | - |
| 310 | Prediction (High) | - | - |
| 376 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | Hsp70 protein | - |
| 380 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | Hsp70 protein | - |
| 589 | Prediction (Medium) | - | - |
| 782 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 14 | Y → C | 0.007299 | SNP | Missense Mutation | READ |
| 428 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 483 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 483 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 483 | R → C | 0.004283 | SNP | Missense Mutation | SKCM |
| 483 | R → C | 0.011321 | SNP | Missense Mutation | UCEC |
| 518 | F → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 740 | C → R | 0.002427 | SNP | Missense Mutation | BLCA |