Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O95757 | HSPA4L | Heat shock 70 kDa protein … | Homo sapiens (Human) | 839 aa |
Protein Details: O95757 (HSPA4L)
Protein Information
| Accession | O95757 |
|---|---|
| Protein Names | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) |
| Gene Symbol | HSPA4L |
| Organism | Homo sapiens (Human) |
| Length | 839 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSVVGIDLGF11LNCYIAVARS21GGIETIANEY31SDRCTPACIS41LGSRTRAIGN
51-10051AAKSQIVTNV61RNTIHGFKKL71HGRSFDDPIV81QTERIRLPYE91LQKMPNGSAG
101-150101VKVRYLEEER111PFAIEQVTGM121LLAKLKETSE131NALKKPVADC141VISIPSFFTD
151-200151AERRSVMAAA161QVAGLNCLRL171MNETTAVALA181YGIYKQDLPP191LDEKPRNVVF
201-250201IDMGHSAYQV211LVCAFNKGKL221KVLATTFDPY231LGGRNFDEAL241VDYFCDEFKT
251-300251KYKINVKENS261RALLRLYQEC271EKLKKLMSAN281ASDLPLNIEC291FMNDLDVSSK
301-350301MNRAQFEQLC311ASLLARVEPP321LKAVMEQANL331QREDISSIEI341VGGATRIPAV
351-400351KEQITKFFLK361DISTTLNADE371AVARGCALQC381AILSPAFKVR391EFSITDLVPY
401-450401SITLRWKTSF411EDGSGECEVF421CKNHPAPFSK431VITFHKKEPF441ELEAFYTNLH
451-500451EVPYPDARIG461SFTIQNVFPQ471SDGDSSKVKV481KVRVNIHGIF491SVASASVIEK
501-550501QNLEGDHSDA511PMETETSFKN521ENKDNMDKMQ531VDQEEGHQKC541HAEHTPEEEI
551-600551DHTGAKTKSA561VSDKQDRLNQ571TLKKGKVKSI581DLPIQSSLCR591QLGQDLLNSY
601-650601IENEGKMIMQ611DKLEKERNDA621KNAVEEYVYD631FRDRLGTVYE641KFITPEDLSK
651-700651LSAVLEDTEN661WLYEDGEDQP671KQVYVDKLQE681LKKYGQPIQM691KYMEHEERPK
701-750701ALNDLGKKIQ711LVMKVIEAYR721NKDERYDHLD731PTEMEKVEKC741ISDAMSWLNS
751-800751KMNAQNKLSL761TQDPVVKVSE771IVAKSKELDN781FCNPIIYKPK791PKAEVPEDKP
801-839801KANSEHNGPM811DGQSGTETKS821DSTKDSSQHT831KSSGEMEVD
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 13 | ATPase, nucleotide binding domain Heat shock protein 70 family | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.77
|
|
| 34 | ATPase, nucleotide binding domain Heat shock protein 70 family | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.87
|
|
| 38 | ATPase, nucleotide binding domain Heat shock protein 70 family | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.83
|
|
| 140 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.94
|
|
| 167 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.96
|
|
| 213 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.95
|
|
| 245 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.56
|
|
| 270 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.97
|
|
| 290 | - | - | - |
Deep-Palm: 0.57
|
|
| 310 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.98
|
|
| 376 | SWISSPALM DBPTM CYSMODDB | Hsp70 protein |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.84
|
| 380 | SWISSPALM DBPTM CYSMODDB | Hsp70 protein | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.85
Deep-Palm: 0.83
|
| 417 | - | - | - |
Deep-Palm: 0.33
|
|
| 421 | - | - | - |
Deep-Palm: 0.09
|
|
| 540 | - | - | - |
Deep-Palm: 0.03
|
|
| 589 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.92
|
|
| 740 | - | - | - |
Deep-Palm: 0.23
|
|
| 782 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.429
3
cerebral cortex
Specificity: 0.273
3/3 (100.0%)
2
LNCaP
Specificity: 0.182
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.091
1/1 (100.0%)
1
293T cell
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 14 | Y → C | 0.007299 | SNP | Missense Mutation | READ |
| 428 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 483 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 483 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 483 | R → C | 0.004283 | SNP | Missense Mutation | SKCM |
| 483 | R → C | 0.011321 | SNP | Missense Mutation | UCEC |
| 518 | F → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 740 | C → R | 0.002427 | SNP | Missense Mutation | BLCA |