Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O95807 | TMEM50A | Transmembrane protein 50A (Small membrane … | Homo sapiens (Human) | 157 aa |
Protein Details: O95807 (TMEM50A)
Protein Information
| Accession | O95807 |
|---|---|
| Protein Names | Transmembrane protein 50A (Small membrane protein 1) |
| Gene Symbol | TMEM50A |
| Organism | Homo sapiens (Human) |
| Length | 157 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSGFLEGLRC11SECIDWGEKR21NTIASIAAGV31LFFTGWWIII41DAAVIYPTMK
51-10051DFNHSYHACG61VIATIAFLMI71NAVSNGQVRG81DSYSEGCLGQ91TGARIWLFVG
101-150101FMLAFGSLIA111SMWILFGGYV121AKEKDIVYPG131IAVFFQNAFI141FFGGLVFKFG
151-157151RTEDLWQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 10 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.76
Deep-Palm: 0.05
|
| 13 | SWISSPALM DBPTM CYSMODDB | Uncharacterised protein family UPF0220 Uncharacterised protein family (UPF0220) |
HeLa
(29575903)
| - |
GPS-Palm: 0.77
Deep-Palm: 0.32
|
| 59 | - | - | - |
Deep-Palm: 0.03
|
|
| 87 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
LNCaP
Specificity: 0.286
4/4 (100.0%)
3
PC3
Specificity: 0.214
3/3 (100.0%)
2
cerebral cortex
Specificity: 0.143
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
Cerebral Cortex (Mass)
Specificity: 0.214
3/4 (75.0%)
2
LNCaP cells (Mass)
Specificity: 0.143
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 20 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 83 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 89 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |