Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| O95837 | GNA14 | Guanine nucleotide-binding protein subunit alpha-14 … | Homo sapiens (Human) | 355 aa |
Protein Details: O95837 (GNA14)
Protein Information
| Accession | O95837 |
|---|---|
| Protein Names | Guanine nucleotide-binding protein subunit alpha-14 (G alpha-14) (G-protein subunit alpha-14) |
| Gene Symbol | GNA14 |
| Organism | Homo sapiens (Human) |
| Length | 355 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 29575903 32944167 33636221 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAGCCCLSAE11EKESQRISAE21IERQLRRDKK31DARRELKLLL41LGTGESGKST
51-10051FIKQMRIIHG61SGYSDEDRKG71FTKLVYQNIF81TAMQAMIRAM91DTLRIQYVCE
101-150101QNKENAQIIR111EVEVDKVSML121SREQVEAIKQ131LWQDPGIQEC141YDRRREYQLS
151-200151DSAKYYLTDI161DRIATPSFVP171TQQDVLRVRV181PTTGIIEYPF191DLENIIFRMV
201-250201DVGGQRSERR211KWIHCFESVT221SIIFLVALSE231YDQVLAECDN241ENRMEESKAL
251-300251FKTIITYPWF261LNSSVILFLN271KKDLLEEKIM281YSHLISYFPE291YTGPKQDVRA
301-350301ARDFILKLYQ311DQNPDKEKVI321YSHFTCATDT331DNIRFVFAAV341KDTILQLNLR
351-355351EFNLV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 4 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.98
Deep-Palm: 0.02
|
| 5 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.02
|
| 6 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.02
|
| 99 | - | - | - |
Deep-Palm: 0.60
|
|
| 140 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.86
|
|
| 215 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.88
|
|
| 238 | - | - | - |
Deep-Palm: 0.83
|
|
| 326 | - | - | - |
Deep-Palm: 0.24
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
PC3
Specificity: 0.571
4/4 (100.0%)
1
HeLa cell
Specificity: 0.143
1/1 (100.0%)
1
heart
Specificity: 0.143
1/1 (100.0%)
1
HUVECs
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 132 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 140 | C → C | 0.002288 | SNP | Silent | STAD |
| 162 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 177 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 243 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 334 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |