Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
O95859 TSPAN12 Tetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane … Homo sapiens (Human) 305 aa

Protein Details: O95859 (TSPAN12)

Protein Information
AccessionO95859
Protein NamesTetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane 4 superfamily member 12)
Gene SymbolTSPAN12
OrganismHomo sapiens (Human)
Length305 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MAREDSVKCL11RCLLYALNLL21FWLMSISVLA31VSAWMRDYLN41NVLTLTAETR
51-10051VEEAVILTYF61PVVHPVMIAV71CCFLIIVGML81GYCGTVKRNL91LLLAWYFGSL
101-150101LVIFCVELAC111GVWTYEQELM121VPVQWSDMVT131LKARMTNYGL141PRYRWLTHAW
151-200151NFFQREFKCC161GVVYFTDWLE171MTEMDWPPDS181CCVREFPGCS191KQAHQEDLSD
201-250201LYQEGCGKKM211YSFLRGTKQL221QVLRFLGISI231GVTQILAMIL241TITLLWALYY
251-300251DRREPGTDQM261MSLKNDNSQH271LSCPSVELLK281PSLSRIFEHT291SMANSFNTHF
301-305301EMEEL
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
9 DBPTM SWISSPALM - - -
GPS-Palm: 0.88
Deep-Palm: 0.05
12 DBPTM SWISSPALM - - -
Deep-Palm: 0.13
71 - - -
GPS-Palm: 0.72
Deep-Palm: 0.05
72 - - -
Deep-Palm: 0.05
83 DBPTM SWISSPALM Tetraspanin family - -
GPS-Palm: 0.92
Deep-Palm: 0.95
105 - - -
Deep-Palm: 0.74
110 - - -
Deep-Palm: 0.13
159 - - -
GPS-Palm: 0.74
Deep-Palm: 0.42
160 - - -
GPS-Palm: 0.77
Deep-Palm: 0.41
181 - - -
Deep-Palm: 0.09
182 - - -
Deep-Palm: 0.09
189 - - -
Deep-Palm: 0.12
206 - - -
GPS-Palm: 0.68
Deep-Palm: 0.90
273 - - -
Deep-Palm: 0.81
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
12 C → W 0.001014 SNP Missense Mutation BRCA
71 C → F 0.002033 SNP Missense Mutation LUSC
95 W → C 0.001887 SNP Missense Mutation UCEC
206 C → G 0.002288 SNP Missense Mutation STAD
206 C → F 0.001764 SNP Missense Mutation LUAD
206 C → Y 0.002506 SNP Missense Mutation COAD
287 F → C 0.001887 SNP Missense Mutation UCEC
159* C → ? 0.001887 SNP Nonsense Mutation UCEC