Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P00352 | ALDH1A1 | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) … | Homo sapiens (Human) | 501 aa |
Protein Details: P00352 (ALDH1A1)
Protein Information
| Accession | P00352 |
|---|---|
| Protein Names | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) |
| Gene Symbol | ALDH1A1 |
| Organism | Homo sapiens (Human) |
| Length | 501 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSSSGTPDLP11VLLTDLKIQY21TKIFINNEWH31DSVSGKKFPV41FNPATEEELC
51-10051QVEEGDKEDV61DKAVKAARQA71FQIGSPWRTM81DASERGRLLY91KLADLIERDR
101-150101LLLATMESMN111GGKLYSNAYL121NDLAGCIKTL131RYCAGWADKI141QGRTIPIDGN
151-200151FFTYTRHEPI161GVCGQIIPWN171FPLVMLIWKI181GPALSCGNTV191VVKPAEQTPL
201-250201TALHVASLIK211EAGFPPGVVN221IVPGYGPTAG231AAISSHMDID241KVAFTGSTEV
251-300251GKLIKEAAGK261SNLKRVTLEL271GGKSPCIVLA281DADLDNAVEF291AHHGVFYHQG
301-350301QCCIAASRIF311VEESIYDEFV321RRSVERAKKY331ILGNPLTPGV341TQGPQIDKEQ
351-400351YDKILDLIES361GKKEGAKLEC371GGGPWGNKGY381FVQPTVFSNV391TDEMRIAKEE
401-450401IFGPVQQIMK411FKSLDDVIKR421ANNTFYGLSA431GVFTKDIDKA441ITISSALQAG
451-500451TVWVNCYGVV461SAQCPFGGFK471MSGNGRELGE481YGFHEYTEVK491TVTVKISQKN
501-501501S
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 50 | Aldehyde dehydrogenase, N-terminal | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.98
|
|
| 126 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.84
|
|
| 133 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.88
|
|
| 163 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.13
|
|
| 186 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.96
|
|
| 276 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.98
|
|
| 302 | - | - | - |
Deep-Palm: 0.20
|
|
| 303 | - | - | - |
Deep-Palm: 0.14
|
|
| 370 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.98
|
|
| 456 | - | - | - |
Deep-Palm: 0.87
|
|
| 464 | - | - | - |
Deep-Palm: 0.94
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
cerebral cortex
Specificity: 0.400
4/4 (100.0%)
1
LNCaP
Specificity: 0.100
1/1 (100.0%)
1
heart
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.400
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 90 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 90 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 100 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 131 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 131 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 151 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 395 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 395 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 456 | C → S | 0.001969 | SNP | Missense Mutation | HNSC |
| 464 | C → C | 0.002506 | SNP | Silent | COAD |
| 464 | C → C | 0.001887 | SNP | Silent | UCEC |