Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P01023 | A2M | Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like … | Homo sapiens (Human) | 1474 aa |
Protein Details: P01023 (A2M)
Protein Information
| Accession | P01023 |
|---|---|
| Protein Names | Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5) |
| Gene Symbol | A2M |
| Organism | Homo sapiens (Human) |
| Length | 1474 aa |
| Isoforms | No isoforms |
| Related PMIDs | 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGKNKLLHPS11LVLLLLVLLP21TDASVSGKPQ31YMVLVPSLLH41TETTEKGCVL
51-10051LSYLNETVTV61SASLESVRGN71RSLFTDLEAE81NDVLHCVAFA91VPKSSSNEEV
101-150101MFLTVQVKGP111TQEFKKRTTV121MVKNEDSLVF131VQTDKSIYKP141GQTVKFRVVS
151-200151MDENFHPLNE161LIPLVYIQDP171KGNRIAQWQS181FQLEGGLKQF191SFPLSSEPFQ
201-250201GSYKVVVQKK211SGGRTEHPFT221VEEFVLPKFE231VQVTVPKIIT241ILEEEMNVSV
251-300251CGLYTYGKPV261PGHVTVSICR271KYSDASDCHG281EDSQAFCEKF291SGQLNSHGCF
301-350301YQQVKTKVFQ311LKRKEYEMKL321HTEAQIQEEG331TVVELTGRQS341SEITRTITKL
351-400351SFVKVDSHFR361QGIPFFGQVR371LVDGKGVPIP381NKVIFIRGNE391ANYYSNATTD
401-450401EHGLVQFSIN411TTNVMGTSLT421VRVNYKDRSP431CYGYQWVSEE441HEEAHHTAYL
451-500451VFSPSKSFVH461LEPMSHELPC471GHTQTVQAHY481ILNGGTLLGL491KKLSFYYLIM
501-550501AKGGIVRTGT511HGLLVKQEDM521KGHFSISIPV531KSDIAPVARL541LIYAVLPTGD
551-600551VIGDSAKYDV561ENCLANKVDL571SFSPSQSLPA581SHAHLRVTAA591PQSVCALRAV
601-650601DQSVLLMKPD611AELSASSVYN621LLPEKDLTGF631PGPLNDQDNE641DCINRHNVYI
651-700651NGITYTPVSS661TNEKDMYSFL671EDMGLKAFTN681SKIRKPKMCP691QLQQYEMHGP
701-750701EGLRVGFYES711DVMGRGHARL721VHVEEPHTET731VRKYFPETWI741WDLVVVNSAG
751-800751VAEVGVTVPD761TITEWKAGAF771CLSEDAGLGI781SSTASLRAFQ791PFFVELTMPY
801-850801SVIRGEAFTL811KATVLNYLPK821CIRVSVQLEA831SPAFLAVPVE841KEQAPHCICA
851-900851NGRQTVSWAV861TPKSLGNVNF871TVSAEALESQ881ELCGTEVPSV891PEHGRKDTVI
901-950901KPLLVEPEGL911EKETTFNSLL921CPSGGEVSEE931LSLKLPPNVV941EESARASVSV
951-1000951LGDILGSAMQ961NTQNLLQMPY971GCGEQNMVLF981APNIYVLDYL991NETQQLTPEI
1001-10501001KSKAIGYLNT1011GYQRQLNYKH1021YDGSYSTFGE1031RYGRNQGNTW1041LTAFVLKTFA
1051-11001051QARAYIFIDE1061AHITQALIWL1071SQRQKDNGCF1081RSSGSLLNNA1091IKGGVEDEVT
1101-11501101LSAYITIALL1111EIPLTVTHPV1121VRNALFCLES1131AWKTAQEGDH1141GSHVYTKALL
1151-12001151AYAFALAGNQ1161DKRKEVLKSL1171NEEAVKKDNS1181VHWERPQKPK1191APVGHFYEPQ
1201-12501201APSAEVEMTS1211YVLLAYLTAQ1221PAPTSEDLTS1231ATNIVKWITK1241QQNAQGGFSS
1251-13001251TQDTVVALHA1261LSKYGAATFT1271RTGKAAQVTI1281QSSGTFSSKF1291QVDNNNRLLL
1301-13501301QQVSLPELPG1311EYSMKVTGEG1321CVYLQTSLKY1331NILPEKEEFP1341FALGVQTLPQ
1351-14001351TCDEPKAHTS1361FQISLSVSYT1371GSRSASNMAI1381VDVKMVSGFI1391PLKPTVKMLE
1401-14501401RSNHVSRTEV1411SSNHVLIYLD1421KVSNQTLSLF1431FTVLQDVPVR1441DLKPAIVKVY
1451-14741451DYYETDEFAI1461AEYNAPCSKD1471LGNA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 48 | - | - | - |
Deep-Palm: 0.89
|
|
| 86 | - | - | - |
Deep-Palm: 0.82
|
|
| 251 | - | - | - |
Deep-Palm: 0.47
|
|
| 269 | - | - | - |
Deep-Palm: 0.26
|
|
| 278 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.19
|
|
| 287 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.10
|
|
| 299 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.86
Deep-Palm: 0.78
|
| 431 | SWISSPALM DBPTM CYSMODDB | Macroglobulin domain MG4 |
HeLa
(29575903)
| - |
Deep-Palm: 0.28
|
| 470 | - | - | - |
Deep-Palm: 0.32
|
|
| 563 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.71
Deep-Palm: 0.79
|
|
| 595 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.88
Deep-Palm: 0.96
|
|
| 642 | - | - | - |
Deep-Palm: 0.06
|
|
| 689 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.67
|
|
| 771 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.95
|
|
| 821 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.88
|
|
| 847 | - | - | - |
Deep-Palm: 0.75
|
|
| 849 | - | - | - |
Deep-Palm: 0.73
|
|
| 883 | - | - | - |
Deep-Palm: 0.94
|
|
| 921 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.98
|
|
| 972 | - | - | - |
Deep-Palm: 0.32
|
|
| 1079 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.92
|
|
| 1127 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.87
|
|
| 1321 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.68
Deep-Palm: 0.89
|
| 1352 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.82
|
|
| 1467 | - | - | - |
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
cerebral cortex
Specificity: 0.444
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.444
4/4 (100.0%)
1
Jurkat T cells (Mass)
Specificity: 0.111
1/10 (10.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 48 | C → R | 0.002288 | SNP | Missense Mutation | STAD |
| 147 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 147 | R → C | 0.008565 | SNP | Missense Mutation | SKCM |
| 166 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 174 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 174 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 299 | C → C | 0.002506 | SNP | Silent | COAD |
| 370 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 515 | V → Cfs*45 | 0.001764 | INS | Frame Shift Ins | LUAD |
| 695 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 719 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 782 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 821 | C → C | 0.001887 | SNP | Silent | UCEC |
| 1055 | Y → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 1102 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1321 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 1330 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1463 | Y → C | 0.017544 | SNP | Missense Mutation | UCS |