Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P01023 A2M; CPAMD5; FWP007 Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like … Homo sapiens (Human) 1474 aa

Protein Details: P01023 (A2M)

Protein Information
Accession P01023
Protein Names Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5)
Gene Symbol A2M; CPAMD5; FWP007
Organism Homo sapiens (Human)
Length 1474 aa
Isoforms No isoforms
Related PMIDs 29575903 36430497
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
4
Cerebral cortex
Specificity: 1.000
4/4 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGKNKLLHPS11LVLLLLVLLP21TDASVSGKPQ31YMVLVPSLLH41TETTEKGCVL
51-10051LSYLNETVTV61SASLESVRGN71RSLFTDLEAE81NDVLHCVAFA91VPKSSSNEEV
101-150101MFLTVQVKGP111TQEFKKRTTV121MVKNEDSLVF131VQTDKSIYKP141GQTVKFRVVS
151-200151MDENFHPLNE161LIPLVYIQDP171KGNRIAQWQS181FQLEGGLKQF191SFPLSSEPFQ
201-250201GSYKVVVQKK211SGGRTEHPFT221VEEFVLPKFE231VQVTVPKIIT241ILEEEMNVSV
251-300251CGLYTYGKPV261PGHVTVSICR271KYSDASDCHG281EDSQAFCEKF291SGQLNSHGCF
301-350301YQQVKTKVFQ311LKRKEYEMKL321HTEAQIQEEG331TVVELTGRQS341SEITRTITKL
351-400351SFVKVDSHFR361QGIPFFGQVR371LVDGKGVPIP381NKVIFIRGNE391ANYYSNATTD
401-450401EHGLVQFSIN411TTNVMGTSLT421VRVNYKDRSP431CYGYQWVSEE441HEEAHHTAYL
451-500451VFSPSKSFVH461LEPMSHELPC471GHTQTVQAHY481ILNGGTLLGL491KKLSFYYLIM
501-550501AKGGIVRTGT511HGLLVKQEDM521KGHFSISIPV531KSDIAPVARL541LIYAVLPTGD
551-600551VIGDSAKYDV561ENCLANKVDL571SFSPSQSLPA581SHAHLRVTAA591PQSVCALRAV
601-650601DQSVLLMKPD611AELSASSVYN621LLPEKDLTGF631PGPLNDQDNE641DCINRHNVYI
651-700651NGITYTPVSS661TNEKDMYSFL671EDMGLKAFTN681SKIRKPKMCP691QLQQYEMHGP
701-750701EGLRVGFYES711DVMGRGHARL721VHVEEPHTET731VRKYFPETWI741WDLVVVNSAG
751-800751VAEVGVTVPD761TITEWKAGAF771CLSEDAGLGI781SSTASLRAFQ791PFFVELTMPY
801-850801SVIRGEAFTL811KATVLNYLPK821CIRVSVQLEA831SPAFLAVPVE841KEQAPHCICA
851-900851NGRQTVSWAV861TPKSLGNVNF871TVSAEALESQ881ELCGTEVPSV891PEHGRKDTVI
901-950901KPLLVEPEGL911EKETTFNSLL921CPSGGEVSEE931LSLKLPPNVV941EESARASVSV
951-1000951LGDILGSAMQ961NTQNLLQMPY971GCGEQNMVLF981APNIYVLDYL991NETQQLTPEI
1001-10501001KSKAIGYLNT1011GYQRQLNYKH1021YDGSYSTFGE1031RYGRNQGNTW1041LTAFVLKTFA
1051-11001051QARAYIFIDE1061AHITQALIWL1071SQRQKDNGCF1081RSSGSLLNNA1091IKGGVEDEVT
1101-11501101LSAYITIALL1111EIPLTVTHPV1121VRNALFCLES1131AWKTAQEGDH1141GSHVYTKALL
1151-12001151AYAFALAGNQ1161DKRKEVLKSL1171NEEAVKKDNS1181VHWERPQKPK1191APVGHFYEPQ
1201-12501201APSAEVEMTS1211YVLLAYLTAQ1221PAPTSEDLTS1231ATNIVKWITK1241QQNAQGGFSS
1251-13001251TQDTVVALHA1261LSKYGAATFT1271RTGKAAQVTI1281QSSGTFSSKF1291QVDNNNRLLL
1301-13501301QQVSLPELPG1311EYSMKVTGEG1321CVYLQTSLKY1331NILPEKEEFP1341FALGVQTLPQ
1351-14001351TCDEPKAHTS1361FQISLSVSYT1371GSRSASNMAI1381VDVKMVSGFI1391PLKPTVKMLE
1401-14501401RSNHVSRTEV1411SSNHVLIYLD1421KVSNQTLSLF1431FTVLQDVPVR1441DLKPAIVKVY
1451-14741451DYYETDEFAI1461AEYNAPCSKD1471LGNA
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
299 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) - 29575903
431 Experimental CYSMODDB SWISSPALM DBPTM Macroglobulin domain MG4 29575903
563 Prediction (Low) - -
595 Prediction (Medium) - -
689 Prediction (Low) - -
771 Prediction (Low) - -
821 Prediction (Medium) - -
921 Prediction (Low) - -
1079 Prediction (Medium) - -
1321 Experimental CYSMODDB SWISSPALM DBPTM Prediction (Low) - 29575903
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
48 C → R 0.002288 SNP Missense Mutation STAD
147 R → C 0.002427 SNP Missense Mutation BLCA
147 R → C 0.008565 SNP Missense Mutation SKCM
166 Y → C 0.001887 SNP Missense Mutation UCEC
174 R → C 0.002506 SNP Missense Mutation COAD
174 R → C 0.001887 SNP Missense Mutation UCEC
299 C → C 0.002506 SNP Silent COAD
370 R → C 0.001887 SNP Missense Mutation UCEC
515 V → Cfs*45 0.001764 INS Frame Shift Ins LUAD
695 Y → C 0.001887 SNP Missense Mutation UCEC
719 R → C 0.001969 SNP Missense Mutation LGG
782 S → C 0.002033 SNP Missense Mutation LUSC
821 C → C 0.001887 SNP Silent UCEC
1055 Y → C 0.001014 SNP Missense Mutation BRCA
1102 S → C 0.001764 SNP Missense Mutation LUAD
1321 C → Y 0.001887 SNP Missense Mutation UCEC
1330 Y → C 0.001887 SNP Missense Mutation UCEC
1463 Y → C 0.017544 SNP Missense Mutation UCS