Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P01024 | C3 | Complement C3 (C3 and PZP-like … | Homo sapiens (Human) | 1663 aa |
Protein Details: P01024 (C3)
Protein Information
| Accession | P01024 |
|---|---|
| Protein Names | Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b (Complement C3b-alpha' chain); Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] |
| Gene Symbol | C3 |
| Organism | Homo sapiens (Human) |
| Length | 1663 aa |
| Isoforms | No isoforms |
| Related PMIDs | 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGPTSGPSLL11LLLLTHLPLA21LGSPMYSIIT31PNILRLESEE41TMVLEAHDAQ
51-10051GDVPVTVTVH61DFPGKKLVLS71SEKTVLTPAT81NHMGNVTFTI91PANREFKSEK
101-150101GRNKFVTVQA111TFGTQVVEKV121VLVSLQSGYL131FIQTDKTIYT141PGSTVLYRIF
151-200151TVNHKLLPVG161RTVMVNIENP171EGIPVKQDSL181SSQNQLGVLP191LSWDIPELVN
201-250201MGQWKIRAYY211ENSPQQVFST221EFEVKEYVLP231SFEVIVEPTE241KFYYIYNEKG
251-300251LEVTITARFL261YGKKVEGTAF271VIFGIQDGEQ281RISLPESLKR291IPIEDGSGEV
301-350301VLSRKVLLDG311VQNPRAEDLV321GKSLYVSATV331ILHSGSDMVQ341AERSGIPIVT
351-400351SPYQIHFTKT361PKYFKPGMPF371DLMVFVTNPD381GSPAYRVPVA391VQGEDTVQSL
401-450401TQGDGVAKLS411INTHPSQKPL421SITVRTKKQE431LSEAEQATRT441MQALPYSTVG
451-500451NSNNYLHLSV461LRTELRPGET471LNVNFLLRMD481RAHEAKIRYY491TYLIMNKGRL
501-550501LKAGRQVREP511GQDLVVLPLS521ITTDFIPSFR531LVAYYTLIGA541SGQREVVADS
551-600551VWVDVKDSCV561GSLVVKSGQS571EDRQPVPGQQ581MTLKIEGDHG591ARVVLVAVDK
601-650601GVFVLNKKNK611LTQSKIWDVV621EKADIGCTPG631SGKDYAGVFS641DAGLTFTSSS
651-700651GQQTAQRAEL661QCPQPAARRR671RSVQLTEKRM681DKVGKYPKEL691RKCCEDGMRE
701-750701NPMRFSCQRR711TRFISLGEAC721KKVFLDCCNY731ITELRRQHAR741ASHLGLARSN
751-800751LDEDIIAEEN761IVSRSEFPES771WLWNVEDLKE781PPKNGISTKL791MNIFLKDSIT
801-850801TWEILAVSMS811DKKGICVADP821FEVTVMQDFF831IDLRLPYSVV841RNEQVEIRAV
851-900851LYNYRQNQEL861KVRVELLHNP871AFCSLATTKR881RHQQTVTIPP891KSSLSVPYVI
901-950901VPLKTGLQEV911EVKAAVYHHF921ISDGVRKSLK931VVPEGIRMNK941TVAVRTLDPE
951-1000951RLGREGVQKE961DIPPADLSDQ971VPDTESETRI981LLQGTPVAQM991TEDAVDAERL
1001-10501001KHLIVTPSGC1011GEQNMIGMTP1021TVIAVHYLDE1031TEQWEKFGLE1041KRQGALELIK
1051-11001051KGYTQQLAFR1061QPSSAFAAFV1071KRAPSTWLTA1081YVVKVFSLAV1091NLIAIDSQVL
1101-11501101CGAVKWLILE1111KQKPDGVFQE1121DAPVIHQEMI1131GGLRNNNEKD1141MALTAFVLIS
1151-12001151LQEAKDICEE1161QVNSLPGSIT1171KAGDFLEANY1181MNLQRSYTVA1191IAGYALAQMG
1201-12501201RLKGPLLNKF1211LTTAKDKNRW1221EDPGKQLYNV1231EATSYALLAL1241LQLKDFDFVP
1251-13001251PVVRWLNEQR1261YYGGGYGSTQ1271ATFMVFQALA1281QYQKDAPDHQ1291ELNLDVSLQL
1301-13501301PSRSSKITHR1311IHWESASLLR1321SEETKENEGF1331TVTAEGKGQG1341TLSVVTMYHA
1351-14001351KAKDQLTCNK1361FDLKVTIKPA1371PETEKRPQDA1381KNTMILEICT1391RYRGDQDATM
1401-14501401SILDISMMTG1411FAPDTDDLKQ1421LANGVDRYIS1431KYELDKAFSD1441RNTLIIYLDK
1451-15001451VSHSEDDCLA1461FKVHQYFNVE1471LIQPGAVKVY1481AYYNLEESCT1491RFYHPEKEDG
1501-15501501KLNKLCRDEL1511CRCAEENCFI1521QKSDDKVTLE1531ERLDKACEPG1541VDYVYKTRLV
1551-16001551KVQLSNDFDE1561YIMAIEQTIK1571SGSDEVQVGQ1581QRTFISPIKC1591REALKLEEKK
1601-16501601HYLMWGLSSD1611FWGEKPNLSY1621IIGKDTWVEH1631WPEEDECQDE1641ENQKQCQDLG
1651-16631651AFTESMVVFG1661CPN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 559 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.94
|
|
| 627 | - | - | - |
Deep-Palm: 0.84
|
|
| 662 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.94
|
|
| 693 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.24
|
|
| 694 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.23
|
|
| 707 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.38
|
|
| 720 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.55
|
|
| 727 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.67
|
|
| 728 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.73
|
|
| 816 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.43
|
|
| 873 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.95
|
|
| 1010 | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.82
Deep-Palm: 0.96
|
|
| 1101 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.89
|
|
| 1158 | - | - | - |
Deep-Palm: 0.97
|
|
| 1358 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.78
|
|
| 1389 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.74
|
|
| 1458 | - | - | - |
Deep-Palm: 0.55
|
|
| 1489 | - | - | - |
Deep-Palm: 0.57
|
|
| 1506 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.46
|
|
| 1511 | - | - | - |
Deep-Palm: 0.44
|
|
| 1513 | - | - | - |
Deep-Palm: 0.51
|
|
| 1518 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.70
|
|
| 1537 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.97
|
|
| 1590 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.91
|
|
| 1637 | - | - | - |
Deep-Palm: 0.06
|
|
| 1646 | - | - | - |
Deep-Palm: 0.09
|
|
| 1661 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.01
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
cerebral cortex
Specificity: 0.500
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.500
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 343 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 450 | G → C | 0.002288 | SNP | Missense Mutation | STAD |
| 481 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 505 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 505 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 505 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 530 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 534 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 535 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 535 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 668 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 686 | Y → Cfs*19 | 0.002294 | INS | Frame Shift Ins | OV |
| 873 | C → Y | 0.002976 | SNP | Missense Mutation | KIRC |
| 951 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 954 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 1009 | G → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 1158 | C → C | 0.002506 | SNP | Silent | COAD |
| 1158 | C → C | 0.001887 | SNP | Silent | UCEC |
| 1219 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1268 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 1454 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 1482 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 1511 | C → C | 0.002141 | SNP | Silent | SKCM |
| 1627 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 1637 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 1658 | V → Cfs*17 | 0.002033 | INS | Frame Shift Ins | LUSC |
| 1590* | C → ? | 0.004219 | SNP | Nonsense Mutation | SARC |