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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P01111 NRAS; HRAS1 GTPase NRas (EC 3.6.5.2) (Transforming … Homo sapiens (Human) 189 aa

Protein Details: P01111 (NRAS)

Protein Information
Accession P01111
Protein Names GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene Symbol NRAS; HRAS1
Organism Homo sapiens (Human)
Length 189 aa
Isoforms No isoforms
Related PMIDs 19801377 21076176 22496122 24357059 25914232 26111759 29575903 29733200 31251020 32944167 33636221 36430497
Database Sources dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.409
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
27
LNCaP cells
Specificity: 0.409
27/46 (58.7%)
10
293T cells
Specificity: 0.152
10/10 (100.0%)
8
Jurkat T cells
Specificity: 0.121
8/25 (32.0%)
4
T cells
Specificity: 0.061
4/4 (100.0%)
4
HAP1 cells
Specificity: 0.061
4/10 (40.0%)
3
PC3 cells
Specificity: 0.045
3/4 (75.0%)
2
DU145 cells
Specificity: 0.030
2/2 (100.0%)
2
CEMx174 cells
Specificity: 0.030
2/3 (66.7%)
2
Endothelial cells
Specificity: 0.030
2/2 (100.0%)
2
Cerebral cortex
Specificity: 0.030
2/4 (50.0%)
1
HeLa cells
Specificity: 0.015
1/1 (100.0%)
1
Liver membrane
Specificity: 0.015
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MTEYKLVVVG11AGGVGKSALT21IQLIQNHFVD31EYDPTIEDSY41RKQVVIDGET
51-10051CLLDILDTAG61QEEYSAMRDQ71YMRTGEGFLC81VFAINNSKSF91ADINLYREQI
101-150101KRVKDSDDVP111MVLVGNKCDL121PTRTVDTKQA131HELAKSYGIP141FIETSAKTRQ
151-189151GVEDAFYTLV161REIRQYRMKK171LNSSDDGTQG181CMGLPCVVM
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
80 Prediction (Medium) - -
118 Prediction (Medium) - -
181 DBPTM SWISSPALM - -
186 Prediction (High) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
12 G → C 0.002506 SNP Missense Mutation COAD
12 G → C 0.014599 SNP Missense Mutation READ
12 G → C 0.002033 SNP Missense Mutation LUSC
164 R → C 0.002506 SNP Missense Mutation COAD
164 R → C 0.003774 SNP Missense Mutation UCEC