Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P01111 | NRAS | GTPase NRas (EC 3.6.5.2) (Transforming … | Homo sapiens (Human) | 189 aa |
Protein Details: P01111 (NRAS)
Protein Information
| Accession | P01111 |
|---|---|
| Protein Names | GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras) |
| Gene Symbol | NRAS |
| Organism | Homo sapiens (Human) |
| Length | 189 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 24357059 25914232 26111759 29575903 29733200 31251020 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | PTMDdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTEYKLVVVG11AGGVGKSALT21IQLIQNHFVD31EYDPTIEDSY41RKQVVIDGET
51-10051CLLDILDTAG61QEEYSAMRDQ71YMRTGEGFLC81VFAINNSKSF91ADINLYREQI
101-150101KRVKDSDDVP111MVLVGNKCDL121PTRTVDTKQA131HELAKSYGIP141FIETSAKTRQ
151-189151GVEDAFYTLV161REIRQYRMKK171LNSSDDGTQG181CMGLPCVVM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 51 | ras sub 4 P-loop containing nucleoside triphosphate hydrolase Small GTPase, Ras-type Small GTPase | - |
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.98
|
|
| 80 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.86
Deep-Palm: 0.85
|
|
| 118 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.96
|
|
| 181 | DBPTM SWISSPALM | - | - | - |
Deep-Palm: 0.03
|
| 186 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.125
3
LNCaP
Specificity: 0.103
3/3 (100.0%)
3
Primary T cell
Specificity: 0.103
3/3 (100.0%)
3
Jurkat T cell
Specificity: 0.103
3/3 (100.0%)
3
PC3
Specificity: 0.103
3/3 (100.0%)
2
HeLa cell
Specificity: 0.069
2/2 (100.0%)
2
CEM 174 cell
Specificity: 0.069
2/2 (100.0%)
2
293T cell
Specificity: 0.069
2/2 (100.0%)
2
cerebral cortex
Specificity: 0.069
2/2 (100.0%)
1
HAP1 cell
Specificity: 0.034
1/1 (100.0%)
1
EC cell
Specificity: 0.034
1/1 (100.0%)
1
heart
Specificity: 0.034
1/1 (100.0%)
1
HUVECs
Specificity: 0.034
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
Cerebral Cortex (Mass)
Specificity: 0.103
3/4 (75.0%)
2
LNCaP cells (Mass)
Specificity: 0.069
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 12 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 12 | G → C | 0.014599 | SNP | Missense Mutation | READ |
| 12 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 164 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 164 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |