Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P01375 | TNF | Tumor necrosis factor (Cachectin) (TNF-alpha) … | Homo sapiens (Human) | 233 aa |
Protein Details: P01375 (TNF)
Protein Information
| Accession | P01375 |
|---|---|
| Protein Names | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] |
| Gene Symbol | TNF |
| Organism | Homo sapiens (Human) |
| Length | 233 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSTESMIRDV11ELAEEALPKK21TGGPQGSRRC31LFLSLFSFLI41VAGATTLFCL
51-10051LHFGVIGPQR61EEFPRDLSLI71SPLAQAVRSS81SRTPSDKPVA91HVVANPQAEG
101-150101QLQWLNRRAN111ALLANGVELR121DNQLVVPSEG131LYLIYSQVLF141KGQGCPSTHV
151-200151LLTHTISRIA161VSYQTKVNLL171SAIKSPCQRE181TPEGAEAKPW191YEPIYLGGVF
201-233201QLEKGDRLSA211EINRPDYLDF221AESGQVYFGI231IAL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 30 | DBPTM SWISSPALM | Tumour necrosis factor alpha | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.98
|
| 49 | DBPTM SWISSPALM | - | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.87
|
| 145 | - | - | - |
Deep-Palm: 0.68
|
|
| 177 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 30 | C → C | 0.027027 | SNP | Silent | DLBC |
| 145 | C → C | 0.001887 | SNP | Silent | UCEC |