Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P01730 | CD4 | T-cell surface glycoprotein CD4 (T-cell … | Homo sapiens (Human) | 458 aa |
Protein Details: P01730 (CD4)
Protein Information
| Accession | P01730 |
|---|---|
| Protein Names | T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4) |
| Gene Symbol | CD4 |
| Organism | Homo sapiens (Human) |
| Length | 458 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26111759 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MNRGVPFRHL11LLVLQLALLP21AATQGKKVVL31GKKGDTVELT41CTASQKKSIQ
51-10051FHWKNSNQIK61ILGNQGSFLT71KGPSKLNDRA81DSRRSLWDQG91NFPLIIKNLK
101-150101IEDSDTYICE111VEDQKEEVQL121LVFGLTANSD131THLLQGQSLT141LTLESPPGSS
151-200151PSVQCRSPRG161KNIQGGKTLS171VSQLELQDSG181TWTCTVLQNQ191KKVEFKIDIV
201-250201VLAFQKASSI211VYKKEGEQVE221FSFPLAFTVE231KLTGSGELWW241QAERASSSKS
251-300251WITFDLKNKE261VSVKRVTQDP271KLQMGKKLPL281HLTLPQALPQ291YAGSGNLTLA
301-350301LEAKTGKLHQ311EVNLVVMRAT321QLQKNLTCEV331WGPTSPKLML341SLKLENKEAK
351-400351VSKREKAVWV361LNPEAGMWQC371LLSDSGQVLL381ESNIKVLPTW391STPVQPMALI
401-450401VLGGVAGLLL411FIGLGIFFCV421RCRHRRRQAE431RMSQIKRLLS441EKKTCQCPHR
451-458451FQKTCSPI
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 41 | Immunoglobulin-like fold Immunoglobulin-like domain Immunoglobulin-like beta-sandwich domain Immunoglobulin-like domain superfamily | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.92
|
|
| 109 | - | - | - |
Deep-Palm: 0.87
|
|
| 155 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.96
|
|
| 184 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.62
|
|
| 328 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.91
|
|
| 370 | - | - | - |
Deep-Palm: 0.97
|
|
| 419 | DBPTM SWISSPALM | T cell CD4 receptor C terminal region | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.98
|
| 422 | DBPTM SWISSPALM | T cell CD4 receptor C terminal region | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
| 445 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.26
|
|
| 447 | - | - | - |
Deep-Palm: 0.03
|
|
| 455 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.01
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Primary T cell
Specificity: 1.000
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 72 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 427 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |