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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P01857 IGHG1 Immunoglobulin heavy constant gamma 1 … Homo sapiens (Human) 399 aa

Protein Details: P01857 (IGHG1)

Protein Information
AccessionP01857
Protein NamesImmunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)
Gene SymbolIGHG1
OrganismHomo sapiens (Human)
Length399 aa
IsoformsNo isoforms
Related PMIDs 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501ASTKGPSVFP11LAPSSKSTSG21GTAALGCLVK31DYFPEPVTVS41WNSGALTSGV
51-10051HTFPAVLQSS61GLYSLSSVVT71VPSSSLGTQT81YICNVNHKPS91NTKVDKKVEP
101-150101KSCDKTHTCP111PCPAPELLGG121PSVFLFPPKP131KDTLMISRTP141EVTCVVVDVS
151-200151HEDPEVKFNW161YVDGVEVHNA171KTKPREEQYN181STYRVVSVLT191VLHQDWLNGK
201-250201EYKCKVSNKA211LPAPIEKTIS221KAKGQPREPQ231VYTLPPSRDE241LTKNQVSLTC
251-300251LVKGFYPSDI261AVEWESNGQP271ENNYKTTPPV281LDSDGSFFLY291SKLTVDKSRW
301-350301QQGNVFSCSV311MHEALHNHYT321QKSLSLSPEL331QLEESCAEAQ341DGELDGLWTT
351-399351ITIFITLFLL361SVCYSATVTF371FKVKWIFSSV381VDLKQTIIPD391YRNMIGQGA
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
27 SWISSPALM DBPTM CYSMODDB Immunoglobulin-like fold Immunoglobulin C1-set domain Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin C1-set
SW480 cell line (26865113)
cerebral cortex (36430497)
GPS-Palm: 0.82
Deep-Palm: 0.92
83 - - -
Deep-Palm: 0.81
103 - - -
Deep-Palm: 0.30
109 - -
cerebral cortex (36430497)
Deep-Palm: 0.78
112 - -
cerebral cortex (36430497)
Deep-Palm: 0.88
144 - -
cerebral cortex (36430497)
Deep-Palm: 0.61
204 - - -
GPS-Palm: 0.69
Deep-Palm: 0.94
250 - -
cerebral cortex (36430497)
GPS-Palm: 0.68
Deep-Palm: 0.77
308 - - -
Deep-Palm: 0.25
336 - - -
Deep-Palm: 0.97
363 - - -
GPS-Palm: 0.79
Deep-Palm: 0.32
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
cerebral cortex
Specificity: 0.500
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.500
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
83 C → W 0.027027 SNP Missense Mutation DLBC
85 G → C 0.001969 SNP Missense Mutation HNSC
112 C → C 0.002506 SNP Silent COAD
112 C → C 0.002141 SNP Silent SKCM
144 C → C 0.005618 SNP Silent PAAD
161 Y → C 0.001969 SNP Missense Mutation LGG
220 S → C 0.002288 SNP Missense Mutation STAD
250 C → C 0.002288 SNP Silent STAD
308 C → Y 0.001887 SNP Missense Mutation UCEC
? ? → ? 0.001014 SNP Missense Mutation BRCA