Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P01889 | HLA-B; HLAB | HLA class I histocompatibility antigen, … | Homo sapiens (Human) | 362 aa |
Protein Details: P01889 (HLA-B)
Protein Information
| Accession | P01889 |
|---|---|
| Protein Names | HLA class I histocompatibility antigen, B alpha chain (Human leukocyte antigen B) (HLA-B) |
| Gene Symbol | HLA-B; HLAB |
| Organism | Homo sapiens (Human) |
| Length | 362 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 24357059 25914232 26111759 31251020 32651440 32944167 |
| Database Sources | dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.619
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
26
LNCaP cells
Specificity: 0.619
26/46 (56.5%)
7
Jurkat T cells
Specificity: 0.167
7/25 (28.0%)
4
PC3 cells
Specificity: 0.095
4/4 (100.0%)
2
DU145 cells
Specificity: 0.048
2/2 (100.0%)
2
CEMx174 cells
Specificity: 0.048
2/3 (66.7%)
1
Endothelial cells
Specificity: 0.024
1/2 (50.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MLVMAPRTVL11LLLSAALALT21ETWAGSHSMR31YFYTSVSRPG41RGEPRFISVG
51-10051YVDDTQFVRF61DSDAASPREE71PRAPWIEQEG81PEYWDRNTQI91YKAQAQTDRE
101-150101SLRNLRGYYN111QSEAGSHTLQ121SMYGCDVGPD131GRLLRGHDQY141AYDGKDYIAL
151-200151NEDLRSWTAA161DTAAQITQRK171WEAAREAEQR181RAYLEGECVE191WLRRYLENGK
201-250201DKLERADPPK211THVTHHPISD221HEATLRCWAL231GFYPAEITLT241WQRDGEDQTQ
251-300251DTELVETRPA261GDRTFQKWAA271VVVPSGEEQR281YTCHVQHEGL291PKPLTLRWEP
301-350301SSQSTVPIVG311IVAGLAVLAV321VVIGAVVAAV331MCRRKSSGGK341GGSYSQAACS
351-362351DSAQGSDVSL361TA
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 125 | Prediction (Low) | - | - |
| 188 | Prediction (Low) | - | - |
| 283 | Prediction (Low) | - | - |
| 332 | DBPTM SWISSPALM Prediction (High) | MHC I C-terminus | - |
| 349 | DBPTM SWISSPALM | MHC I C-terminus | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 50 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 51 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 75 | W → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 219 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 304 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 312 | V → Cfs*22 | 0.002506 | INS | Frame Shift Ins | COAD |
| 227* | C → ? | 0.002141 | SNP | Nonsense Mutation | SKCM |