Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P01889 | HLA-B | HLA class I histocompatibility antigen, … | Homo sapiens (Human) | 362 aa |
Protein Details: P01889 (HLA-B)
Protein Information
| Accession | P01889 |
|---|---|
| Protein Names | HLA class I histocompatibility antigen, B alpha chain (Human leukocyte antigen B) (HLA-B) |
| Gene Symbol | HLA-B |
| Organism | Homo sapiens (Human) |
| Length | 362 aa |
| Isoforms | No isoforms |
| Related PMIDs | 24357059 25914232 26111759 31251020 32651440 |
| Database Sources | dbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLVMAPRTVL11LLLSAALALT21ETWAGSHSMR31YFYTSVSRPG41RGEPRFISVG
51-10051YVDDTQFVRF61DSDAASPREE71PRAPWIEQEG81PEYWDRNTQI91YKAQAQTDRE
101-150101SLRNLRGYYN111QSEAGSHTLQ121SMYGCDVGPD131GRLLRGHDQY141AYDGKDYIAL
151-200151NEDLRSWTAA161DTAAQITQRK171WEAAREAEQR181RAYLEGECVE191WLRRYLENGK
201-250201DKLERADPPK211THVTHHPISD221HEATLRCWAL231GFYPAEITLT241WQRDGEDQTQ
251-300251DTELVETRPA261GDRTFQKWAA271VVVPSGEEQR281YTCHVQHEGL291PKPLTLRWEP
301-350301SSQSTVPIVG311IVAGLAVLAV321VVIGAVVAAV331MCRRKSSGGK341GGSYSQAACS
351-362351DSAQGSDVSL361TA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 125 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.90
|
|
| 188 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.98
|
|
| 227 | - | - | - |
Deep-Palm: 0.09
|
|
| 283 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.94
|
|
| 332 | DBPTM SWISSPALM | MHC I C-terminus | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.98
|
| 349 | DBPTM SWISSPALM | MHC I C-terminus | - | - |
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
5
Jurkat T cell
Specificity: 0.500
5/5 (100.0%)
2
LNCaP
Specificity: 0.200
2/2 (100.0%)
2
CEM 174 cell
Specificity: 0.200
2/2 (100.0%)
1
HUVECs
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 50 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 51 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 75 | W → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 219 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 304 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 312 | V → Cfs*22 | 0.002506 | INS | Frame Shift Ins | COAD |
| 227* | C → ? | 0.002141 | SNP | Nonsense Mutation | SKCM |