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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P02749 APOH Beta-2-glycoprotein 1 (APC inhibitor) (Activated … Homo sapiens (Human) 345 aa

Protein Details: P02749 (APOH)

Protein Information
AccessionP02749
Protein NamesBeta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Anticardiolipin cofactor) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI)
Gene SymbolAPOH
OrganismHomo sapiens (Human)
Length345 aa
IsoformsNo isoforms
Related PMIDs 33636221
Database SourcesSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MISPVLILFS11SFLCHVAIAG21RTCPKPDDLP31FSTVVPLKTF41YEPGEEITYS
51-10051CKPGYVSRGG61MRKFICPLTG71LWPINTLKCT81PRVCPFAGIL91ENGAVRYTTF
101-150101EYPNTISFSC111NTGFYLNGAD121SAKCTEEGKW131SPELPVCAPI141ICPPPSIPTF
151-200151ATLRVYKPSA161GNNSLYRDTA171VFECLPQHAM181FGNDTITCTT191HGNWTKLPEC
201-250201REVKCPFPSR211PDNGFVNYPA221KPTLYYKDKA231TFGCHDGYSL241DGPEEIECTK
251-300251LGNWSAMPSC261KASCKVPVKK271ATVVYQGERV281KIQEKFKNGM291LHGDKVSFFC
301-345301KNKEKKCSYT311EDAQCIDGTI321EVPKCFKEHS331SLAFWKTDAS341DVKPC
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
14 - - -
Deep-Palm: 0.39
23 - - -
Deep-Palm: 0.86
51 Complement Module, domain 1 Sushi/SCR/CCP domain - -
Deep-Palm: 0.65
66 - - -
GPS-Palm: 0.93
Deep-Palm: 0.68
79 - - -
GPS-Palm: 0.73
Deep-Palm: 0.73
84 - - -
GPS-Palm: 0.93
Deep-Palm: 0.80
110 - - -
Deep-Palm: 0.04
124 - - -
Deep-Palm: 0.45
137 - - -
Deep-Palm: 0.34
142 - - -
Deep-Palm: 0.47
174 - - -
Deep-Palm: 0.10
188 - - -
Deep-Palm: 0.05
200 - - -
Deep-Palm: 0.05
205 - - -
Deep-Palm: 0.06
234 - - -
Deep-Palm: 0.37
248 - - -
Deep-Palm: 0.21
260 - - -
GPS-Palm: 0.87
Deep-Palm: 0.57
264 - - -
GPS-Palm: 0.70
Deep-Palm: 0.72
300 - - -
GPS-Palm: 0.68
Deep-Palm: 0.08
307 - - -
Deep-Palm: 0.06
315 - - -
Deep-Palm: 0.12
325 - - -
Deep-Palm: 0.34
345 - - -
GPS-Palm: 0.97
Deep-Palm: 0.03
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
heart
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
55 Y → C 0.001887 SNP Missense Mutation UCEC
96 R → C 0.001887 SNP Missense Mutation UCEC
110 C → C 0.002033 SNP Silent LUSC
154 R → C 0.001969 SNP Missense Mutation HNSC
154 R → C 0.001887 SNP Missense Mutation UCEC
205 C → Y 0.002545 SNP Missense Mutation GBM
242 G → C 0.002294 SNP Missense Mutation OV
307 C → Y 0.003460 SNP Missense Mutation CESC
315 C → Y 0.001887 SNP Missense Mutation UCEC
315* C → ? 0.002033 SNP Nonsense Mutation LUSC