Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P02786 | TFRC | Transferrin receptor protein 1 (TR) … | Homo sapiens (Human) | 760 aa |
Protein Details: P02786 (TFRC)
Protein Information
| Accession | P02786 |
|---|---|
| Protein Names | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (Transferrin receptor 1) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] |
| Gene Symbol | TFRC |
| Organism | Homo sapiens (Human) |
| Length | 760 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 19801377 21076176 22496122 24357059 25914232 26111759 29575903 29733200 31251020 31382980 32651440 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MMDQARSAFS11NLFGGEPLSY21TRFSLARQVD31GDNSHVEMKL41AVDEEENADN
51-10051NTKANVTKPK61RCSGSICYGT71IAVIVFFLIG81FMIGYLGYCK91GVEPKTECER
101-150101LAGTESPVRE111EPGEDFPAAR121RLYWDDLKRK131LSEKLDSTDF141TGTIKLLNEN
151-200151SYVPREAGSQ161KDENLALYVE171NQFREFKLSK181VWRDQHFVKI191QVKDSAQNSV
201-250201IIVDKNGRLV211YLVENPGGYV221AYSKAATVTG231KLVHANFGTK241KDFEDLYTPV
251-300251NGSIVIVRAG261KITFAEKVAN271AESLNAIGVL281IYMDQTKFPI291VNAELSFFGH
301-350301AHLGTGDPYT311PGFPSFNHTQ321FPPSRSSGLP331NIPVQTISRA341AAEKLFGNME
351-400351GDCPSDWKTD361STCRMVTSES371KNVKLTVSNV381LKEIKILNIF391GVIKGFVEPD
401-450401HYVVVGAQRD411AWGPGAAKSG421VGTALLLKLA431QMFSDMVLKD441GFQPSRSIIF
451-500451ASWSAGDFGS461VGATEWLEGY471LSSLHLKAFT481YINLDKAVLG491TSNFKVSASP
501-550501LLYTLIEKTM511QNVKHPVTGQ521FLYQDSNWAS531KVEKLTLDNA541AFPFLAYSGI
551-600551PAVSFCFCED561TDYPYLGTTM571DTYKELIERI581PELNKVARAA591AEVAGQFVIK
601-650601LTHDVELNLD611YERYNSQLLS621FVRDLNQYRA631DIKEMGLSLQ641WLYSARGDFF
651-700651RATSRLTTDF661GNAEKTDRFV671MKKLNDRVMR681VEYHFLSPYV691SPKESPFRHV
701-750701FWGSGSHTLP711ALLENLKLRK721QNNGAFNETL731FRNQLALATW741TIQGAANALS
751-760751GDVWDIDNEF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 62 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.55
|
| 67 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(37611173)
| - |
GPS-Palm: 0.80
Deep-Palm: 0.62
|
| 89 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.86
|
|
| 98 | - | - | - |
Deep-Palm: 0.93
|
|
| 353 | - |
HeLa
(29575903)
|
LNCaP
(31251020)
|
Deep-Palm: 0.90
|
|
| 363 | - |
HeLa
(29575903)
| - |
Deep-Palm: 0.59
|
|
| 556 | - | - | - |
Deep-Palm: 0.28
|
|
| 558 | - | - | - |
Deep-Palm: 0.18
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.138
4
LNCaP
Specificity: 0.133
4/4 (100.0%)
4
Primary T cell
Specificity: 0.133
4/4 (100.0%)
4
PC3
Specificity: 0.133
4/4 (100.0%)
3
Jurkat T cell
Specificity: 0.100
3/3 (100.0%)
3
CEM 174 cell
Specificity: 0.100
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.067
2/2 (100.0%)
2
HeLa cell
Specificity: 0.067
2/2 (100.0%)
1
U937 cell
Specificity: 0.033
1/1 (100.0%)
1
EC cell
Specificity: 0.033
1/1 (100.0%)
1
293T cell
Specificity: 0.033
1/1 (100.0%)
1
cerebral cortex
Specificity: 0.033
1/1 (100.0%)
1
heart
Specificity: 0.033
1/1 (100.0%)
1
HUVECs
Specificity: 0.033
1/1 (100.0%)
1
DU145 cell
Specificity: 0.033
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.033
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 152 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 174 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 174 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 174 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 321 | F → delinsLEYVALILIC | 0.002294 | INS | In Frame Ins | OV |
| 338 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 646 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 719 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 719 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 719 | R → C | 0.003460 | SNP | Missense Mutation | CESC |