Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P03372 ESR1 Estrogen receptor (ER) (ER-alpha) (Estradiol … Homo sapiens (Human) 595 aa

Protein Details: P03372 (ESR1)

Protein Information
AccessionP03372
Protein NamesEstrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene SymbolESR1
OrganismHomo sapiens (Human)
Length595 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MTMTLHTKAS11GMALLHQIQG21NELEPLNRPQ31LKIPLERPLG41EVYLDSSKPA
51-10051VYNYPEGAAY61EFNAAAAANA71QVYGQTGLPY81GPGSEAAAFG91SNGLGGFPPL
101-150101NSVSPSPLML111LHPPPQLSPF121LQPHGQQVPY131YLENEPSGYT141VREAGPPAFY
151-200151RPNSDNRRQG161GRERLASTND171KGSMAMESAK181ETRYCAVCND191YASGYHYGVW
201-250201SCEGCKAFFK211RSIQGHNDYM221CPATNQCTID231KNRRKSCQAC241RLRKCYEVGM
251-300251MKGGIRKDRR261GGRMLKHKRQ271RDDGEGRGEV281GSAGDMRAAN291LWPSPLMIKR
301-350301SKKNSLALSL311TADQMVSALL321DAEPPILYSE331YDPTRPFSEA341SMMGLLTNLA
351-400351DRELVHMINW361AKRVPGFVDL371TLHDQVHLLE381CAWLEILMIG391LVWRSMEHPG
401-450401KLLFAPNLLL411DRNQGKCVEG421MVEIFDMLLA431TSSRFRMMNL441QGEEFVCLKS
451-500451IILLNSGVYT461FLSSTLKSLE471EKDHIHRVLD481KITDTLIHLM491AKAGLTLQQQ
501-550501HQRLAQLLLI511LSHIRHMSNK521GMEHLYSMKC531KNVVPLYDLL541LEMLDAHRLH
551-595551APTSRGGASV561EETDQSHLAT571AGSTSSHSLQ581KYYITGEAEG591FPATV
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
185 - - -
Deep-Palm: 0.04
188 - - -
Deep-Palm: 0.03
202 - - -
Deep-Palm: 0.03
205 - - -
Deep-Palm: 0.04
221 - - -
Deep-Palm: 0.09
227 - - -
GPS-Palm: 0.65
Deep-Palm: 0.03
237 - - -
GPS-Palm: 0.80
Deep-Palm: 0.11
240 - - -
GPS-Palm: 0.74
Deep-Palm: 0.20
245 - - -
Deep-Palm: 0.44
381 - - -
Deep-Palm: 0.47
417 - - -
Deep-Palm: 0.89
447 DBPTM SWISSPALM - - -
GPS-Palm: 0.91
Deep-Palm: 0.90
530 - - -
Deep-Palm: 0.59
Score Interpretation:
GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
10 S → C 0.007299 SNP Missense Mutation READ
188 C → R 0.001887 SNP Missense Mutation UCEC
197 Y → C 0.001969 SNP Missense Mutation HNSC
240 C → Y 0.002288 SNP Missense Mutation STAD
243 R → C 0.002141 SNP Missense Mutation SKCM
278 G → C 0.001764 SNP Missense Mutation LUAD
394 R → C 0.002747 SNP Missense Mutation LIHC
415 G → _C417del 0.001887 DEL In Frame Del UCEC
537 Y → C 0.001887 SNP Missense Mutation UCEC
548 R → C 0.001969 SNP Missense Mutation LGG
237* C → ? 0.001764 SNP Nonsense Mutation LUAD
227* C → ? 0.002506 SNP Nonsense Mutation COAD