Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P04003 | C4BPA | C4b-binding protein alpha chain (C4bp) … | Homo sapiens (Human) | 597 aa |
Protein Details: P04003 (C4BPA)
Protein Information
| Accession | P04003 |
|---|---|
| Protein Names | C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP) |
| Gene Symbol | C4BPA |
| Organism | Homo sapiens (Human) |
| Length | 597 aa |
| Isoforms | No isoforms |
| Related PMIDs | 33636221 |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MHPPKTPSGA11LHRKRKMAAW21PFSRLWKVSD31PILFQMTLIA41ALLPAVLGNC
51-10051GPPPTLSFAA61PMDITLTETR71FKTGTTLKYT81CLPGYVRSHS91TQTLTCNSDG
101-150101EWVYNTFCIY111KRCRHPGELR121NGQVEIKTDL131SFGSQIEFSC141SEGFFLIGST
151-200151TSRCEVQDRG161VGWSHPLPQC171EIVKCKPPPD181IRNGRHSGEE191NFYAYGFSVT
201-250201YSCDPRFSLL211GHASISCTVE221NETIGVWRPS231PPTCEKITCR241KPDVSHGEMV
251-300251SGFGPIYNYK261DTIVFKCQKG271FVLRGSSVIH281CDADSKWNPS291PPACEPNSCI
301-350301NLPDIPHASW311ETYPRPTKED321VYVVGTVLRY331RCHPGYKPTT341DEPTTVICQK
351-400351NLRWTPYQGC361EALCCPEPKL371NNGEITQHRK381SRPANHCVYF391YGDEISFSCH
401-450401ETSRFSAICQ411GDGTWSPRTP421SCGDICNFPP431KIAHGHYKQS441SSYSFFKEEI
451-500451IYECDKGYIL461VGQAKLSCSY471SHWSAPAPQC481KALCRKPELV491NGRLSVDKDQ
501-550501YVEPENVTIQ511CDSGYGVVGP521QSITCSGNRT531WYPEVPKCEW541ETPEGCEQVL
551-597551TGKRLMQCLP561NPEDVKMALE571VYKLSLEIEQ581LELQRDSARQ591STLDKEL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 50 | - | - | - |
Deep-Palm: 0.96
|
|
| 81 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.71
|
|
| 96 | - | - | - |
Deep-Palm: 0.03
|
|
| 108 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.02
|
|
| 113 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.12
|
|
| 140 | - | - | - |
Deep-Palm: 0.43
|
|
| 154 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.43
|
|
| 170 | - | - | - |
Deep-Palm: 0.53
|
|
| 175 | - | - | - |
Deep-Palm: 0.34
|
|
| 203 | - | - | - |
Deep-Palm: 0.20
|
|
| 217 | - | - | - |
Deep-Palm: 0.44
|
|
| 234 | - | - | - |
Deep-Palm: 0.39
|
|
| 239 | - | - | - |
Deep-Palm: 0.14
|
|
| 267 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.15
|
|
| 281 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.49
|
|
| 294 | - | - | - |
Deep-Palm: 0.02
|
|
| 299 | - | - | - |
Deep-Palm: 0.06
|
|
| 332 | - | - | - |
Deep-Palm: 0.65
|
|
| 348 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.19
|
|
| 360 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.15
|
|
| 364 | - | - | - |
Deep-Palm: 0.34
|
|
| 365 | - | - | - |
Deep-Palm: 0.34
|
|
| 387 | - | - | - |
Deep-Palm: 0.08
|
|
| 399 | - | - | - |
Deep-Palm: 0.03
|
|
| 409 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.05
|
|
| 422 | - | - | - |
Deep-Palm: 0.04
|
|
| 426 | - | - | - |
Deep-Palm: 0.37
|
|
| 454 | - | - | - |
Deep-Palm: 0.42
|
|
| 468 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.73
|
|
| 480 | - | - | - |
Deep-Palm: 0.37
|
|
| 484 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.89
|
|
| 511 | - | - | - |
Deep-Palm: 0.16
|
|
| 525 | - | - | - |
Deep-Palm: 0.23
|
|
| 538 | - | - | - |
Deep-Palm: 0.08
|
|
| 546 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.43
|
|
| 558 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
heart
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 70 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 154 | C → F | 0.001887 | SNP | Missense Mutation | UCEC |
| 198 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 234 | C → Lfs*3 | 0.001887 | INS | Nonsense Mutation | UCEC |
| 267 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 267 | C → F | 0.002033 | SNP | Missense Mutation | LUSC |
| 361 | E → _A362insCL | 0.001969 | INS | In Frame Ins | HNSC |
| 364 | C → G | 0.001887 | SNP | Missense Mutation | UCEC |
| 391 | Y → C | 0.003460 | SNP | Missense Mutation | CESC |
| 409 | C → C | 0.001887 | SNP | Silent | UCEC |
| 591 | S → C | 0.002141 | SNP | Missense Mutation | SKCM |