Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P04083 | ANXA1 | Annexin A1 (Annexin I) (Annexin-1) … | Homo sapiens (Human) | 346 aa |
Protein Details: P04083 (ANXA1)
Protein Information
| Accession | P04083 |
|---|---|
| Protein Names | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] |
| Gene Symbol | ANXA1 |
| Organism | Homo sapiens (Human) |
| Length | 346 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAMVSEFLKQ11AWFIENEEQE21YVQTVKSSKG31GPGSAVSPYP41TFNPSSDVAA
51-10051LHKAIMVKGV61DEATIIDILT71KRNNAQRQQI81KAAYLQETGK91PLDETLKKAL
101-150101TGHLEEVVLA111LLKTPAQFDA121DELRAAMKGL131GTDEDTLIEI141LASRTNKEIR
151-200151DINRVYREEL161KRDLAKDITS171DTSGDFRNAL181LSLAKGDRSE191DFGVNEDLAD
201-250201SDARALYEAG211ERRKGTDVNV221FNTILTTRSY231PQLRRVFQKY241TKYSKHDMNK
251-300251VLDLELKGDI261EKCLTAIVKC271ATSKPAFFAE281KLHQAMKGVG291TRHKALIRIM
301-346301VSRSEIDMND311IKAFYQKMYG321ISLCQAILDE331TKGDYEKILV341ALCGGN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 263 | SWISSPALM DBPTM CYSMODDB | Annexin | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.98
|
| 270 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.93
|
|
| 324 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.95
|
|
| 343 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.98
Deep-Palm: 0.05
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
frontal cortex
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 102 | G → C | 0.002545 | SNP | Missense Mutation | GBM |
| 234 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 335 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |