Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P04083 | ANXA1; ANX1; LPC1 | Annexin A1 (Annexin I) (Annexin-1) … | Homo sapiens (Human) | 346 aa |
Protein Details: P04083 (ANXA1)
Protein Information
| Accession | P04083 |
|---|---|
| Protein Names | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] |
| Gene Symbol | ANXA1; ANX1; LPC1 |
| Organism | Homo sapiens (Human) |
| Length | 346 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 26876311 29575903 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
4
PC3 cells
Specificity: 0.571
4/4 (100.0%)
2
Jurkat T cells
Specificity: 0.286
2/25 (8.0%)
1
Prefrontal cortex
Specificity: 0.143
1/1 (100.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
LNCaP cells
Specificity: 0.000
0/46 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MAMVSEFLKQ11AWFIENEEQE21YVQTVKSSKG31GPGSAVSPYP41TFNPSSDVAA
51-10051LHKAIMVKGV61DEATIIDILT71KRNNAQRQQI81KAAYLQETGK91PLDETLKKAL
101-150101TGHLEEVVLA111LLKTPAQFDA121DELRAAMKGL131GTDEDTLIEI141LASRTNKEIR
151-200151DINRVYREEL161KRDLAKDITS171DTSGDFRNAL181LSLAKGDRSE191DFGVNEDLAD
201-250201SDARALYEAG211ERRKGTDVNV221FNTILTTRSY231PQLRRVFQKY241TKYSKHDMNK
251-300251VLDLELKGDI261EKCLTAIVKC271ATSKPAFFAE281KLHQAMKGVG291TRHKALIRIM
301-346301VSRSEIDMND311IKAFYQKMYG321ISLCQAILDE331TKGDYEKILV341ALCGGN
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 263 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | Annexin | - |
| 270 | Prediction (Medium) | - | - |
| 324 | Prediction (Low) | - | - |
| 343 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) | - | 29575903 |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 102 | G → C | 0.002545 | SNP | Missense Mutation | GBM |
| 234 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 335 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |