Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P04114 APOB Apolipoprotein B-100 (Apo B-100) [Cleaved … Homo sapiens (Human) 4563 aa

Protein Details: P04114 (APOB)

Protein Information
AccessionP04114
Protein NamesApolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]
Gene SymbolAPOB
OrganismHomo sapiens (Human)
Length4563 aa
IsoformsNo isoforms
Related PMIDs 33636221
Database SourcesdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MDPPRPALLA11LLALPALLLL21LLAGARAEEE31MLENVSLVCP41KDATRFKHLR
51-10051KYTYNYEAES61SSGVPGTADS71RSATRINCKV81ELEVPQLCSF91ILKTSQCTLK
101-150101EVYGFNPEGK111ALLKKTKNSE121EFAAAMSRYE131LKLAIPEGKQ141VFLYPEKDEP
151-200151TYILNIKRGI161ISALLVPPET171EEAKQVLFLD181TVYGNCSTHF191TVKTRKGNVA
201-250201TEISTERDLG211QCDRFKPIRT221GISPLALIKG231MTRPLSTLIS241SSQSCQYTLD
251-300251AKRKHVAEAI261CKEQHLFLPF271SYKNKYGMVA281QVTQTLKLED291TPKINSRFFG
301-350301EGTKKMGLAF311ESTKSTSPPK321QAEAVLKTLQ331ELKKLTISEQ341NIQRANLFNK
351-400351LVTELRGLSD361EAVTSLLPQL371IEVSSPITLQ381ALVQCGQPQC391STHILQWLKR
401-450401VHANPLLIDV411VTYLVALIPE421PSAQQLREIF431NMARDQRSRA441TLYALSHAVN
451-500451NYHKTNPTGT461QELLDIANYL471MEQIQDDCTG481DEDYTYLILR491VIGNMGQTME
501-550501QLTPELKSSI511LKCVQSTKPS521LMIQKAAIQA531LRKMEPKDKD541QEVLLQTFLD
551-600551DASPGDKRLA561AYLMLMRSPS571QADINKIVQI581LPWEQNEQVK591NFVASHIANI
601-650601LNSEELDIQD611LKKLVKEALK621ESQLPTVMDF631RKFSRNYQLY641KSVSLPSLDP
651-700651ASAKIEGNLI661FDPNNYLPKE671SMLKTTLTAF681GFASADLIEI691GLEGKGFEPT
701-750701LEALFGKQGF711FPDSVNKALY721WVNGQVPDGV731SKVLVDHFGY741TKDDKHEQDM
751-800751VNGIMLSVEK761LIKDLKSKEV771PEARAYLRIL781GEELGFASLH791DLQLLGKLLL
801-850801MGARTLQGIP811QMIGEVIRKG821SKNDFFLHYI831FMENAFELPT841GAGLQLQISS
851-900851SGVIAPGAKA861GVKLEVANMQ871AELVAKPSVS881VEFVTNMGII891IPDFARSGVQ
901-950901MNTNFFHESG911LEAHVALKAG921KLKFIIPSPK931RPVKLLSGGN941TLHLVSTTKT
951-1000951EVIPPLIENR961QSWSVCKQVF971PGLNYCTSGA981YSNASSTDSA991SYYPLTGDTR
1001-10501001LELELRPTGE1011IEQYSVSATY1021ELQREDRALV1031DTLKFVTQAE1041GAKQTEATMT
1051-11001051FKYNRQSMTL1061SSEVQIPDFD1071VDLGTILRVN1081DESTEGKTSY1091RLTLDIQNKK
1101-11501101ITEVALMGHL1111SCDTKEERKI1121KGVISIPRLQ1131AEARSEILAH1141WSPAKLLLQM
1151-12001151DSSATAYGST1161VSKRVAWHYD1171EEKIEFEWNT1181GTNVDTKKMT1191SNFPVDLSDY
1201-12501201PKSLHMYANR1211LLDHRVPQTD1221MTFRHVGSKL1231IVAMSSWLQK1241ASGSLPYTQT
1251-13001251LQDHLNSLKE1261FNLQNMGLPD1271FHIPENLFLK1281SDGRVKYTLN1291KNSLKIEIPL
1301-13501301PFGGKSSRDL1311KMLETVRTPA1321LHFKSVGFHL1331PSREFQVPTF1341TIPKLYQLQV
1351-14001351PLLGVLDLST1361NVYSNLYNWS1371ASYSGGNTST1381DHFSLRARYH1391MKADSVVDLL
1401-14501401SYNVQGSGET1411TYDHKNTFTL1421SCDGSLRHKF1431LDSNIKFSHV1441EKLGNNPVSK
1451-15001451GLLIFDASSS1461WGPQMSASVH1471LDSKKKQHLF1481VKEVKIDGQF1491RVSSFYAKGT
1501-15501501YGLSCQRDPN1511TGRLNGESNL1521RFNSSYLQGT1531NQITGRYEDG1541TLSLTSTSDL
1551-16001551QSGIIKNTAS1561LKYENYELTL1571KSDTNGKYKN1581FATSNKMDMT1591FSKQNALLRS
1601-16501601EYQADYESLR1611FFSLLSGSLN1621SHGLELNADI1631LGTDKINSGA1641HKATLRIGQD
1651-17001651GISTSATTNL1661KCSLLVLENE1671LNAELGLSGA1681SMKLTTNGRF1691REHNAKFSLD
1701-17501701GKAALTELSL1711GSAYQAMILG1721VDSKNIFNFK1731VSQEGLKLSN1741DMMGSYAEMK
1751-18001751FDHTNSLNIA1761GLSLDFSSKL1771DNIYSSDKFY1781KQTVNLQLQP1791YSLVTTLNSD
1801-18501801LKYNALDLTN1811NGKLRLEPLK1821LHVAGNLKGA1831YQNNEIKHIY1841AISSAALSAS
1851-19001851YKADTVAKVQ1861GVEFSHRLNT1871DIAGLASAID1881MSTNYNSDSL1891HFSNVFRSVM
1901-19501901APFTMTIDAH1911TNGNGKLALW1921GEHTGQLYSK1931FLLKAEPLAF1941TFSHDYKGST
1951-20001951SHHLVSRKSI1961SAALEHKVSA1971LLTPAEQTGT1981WKLKTQFNNN1991EYSQDLDAYN
2001-20502001TKDKIGVELT2011GRTLADLTLL2021DSPIKVPLLL2031SEPINIIDAL2041EMRDAVEKPQ
2051-21002051EFTIVAFVKY2061DKNQDVHSIN2071LPFFETLQEY2081FERNRQTIIV2091VLENVQRNLK
2101-21502101HINIDQFVRK2111YRAALGKLPQ2121QANDYLNSFN2131WERQVSHAKE2141KLTALTKKYR
2151-22002151ITENDIQIAL2161DDAKINFNEK2171LSQLQTYMIQ2181FDQYIKDSYD2191LHDLKIAIAN
2201-22502201IIDEIIEKLK2211SLDEHYHIRV2221NLVKTIHDLH2231LFIENIDFNK2241SGSSTASWIQ
2251-23002251NVDTKYQIRI2261QIQEKLQQLK2271RHIQNIDIQH2281LAGKLKQHIE2291AIDVRVLLDQ
2301-23502301LGTTISFERI2311NDILEHVKHF2321VINLIGDFEV2331AEKINAFRAK2341VHELIERYEV
2351-24002351DQQIQVLMDK2361LVELAHQYKL2371KETIQKLSNV2381LQQVKIKDYF2391EKLVGFIDDA
2401-24502401VKKLNELSFK2411TFIEDVNKFL2421DMLIKKLKSF2431DYHQFVDETN2441DKIREVTQRL
2451-25002451NGEIQALELP2461QKAEALKLFL2471EETKATVAVY2481LESLQDTKIT2491LIINWLQEAL
2501-25502501SSASLAHMKA2511KFRETLEDTR2521DRMYQMDIQQ2531ELQRYLSLVG2541QVYSTLVTYI
2551-26002551SDWWTLAAKN2561LTDFAEQYSI2571QDWAKRMKAL2581VEQGFTVPEI2591KTILGTMPAF
2601-26502601EVSLQALQKA2611TFQTPDFIVP2621LTDLRIPSVQ2631INFKDLKNIK2641IPSRFSTPEF
2651-27002651TILNTFHIPS2661FTIDFVEMKV2671KIIRTIDQML2681NSELQWPVPD2691IYLRDLKVED
2701-27502701IPLARITLPD2711FRLPEIAIPE2721FIIPTLNLND2731FQVPDLHIPE2741FQLPHISHTI
2751-28002751EVPTFGKLYS2761ILKIQSPLFT2771LDANADIGNG2781TTSANEAGIA2791ASITAKGESK
2801-28502801LEVLNFDFQA2811NAQLSNPKIN2821PLALKESVKF2831SSKYLRTEHG2841SEMLFFGNAI
2851-29002851EGKSNTVASL2861HTEKNTLELS2871NGVIVKINNQ2881LTLDSNTKYF2891HKLNIPKLDF
2901-29502901SSQADLRNEI2911KTLLKAGHIA2921WTSSGKGSWK2931WACPRFSDEG2941THESQISFTI
2951-30002951EGPLTSFGLS2961NKINSKHLRV2971NQNLVYESGS2981LNFSKLEIQS2991QVDSQHVGHS
3001-30503001VLTAKGMALF3011GEGKAEFTGR3021HDAHLNGKVI3031GTLKNSLFFS3041AQPFEITAST
3051-31003051NNEGNLKVRF3061PLRLTGKIDF3071LNNYALFLSP3081SAQQASWQVS3091ARFNQYKYNQ
3101-31503101NFSAGNNENI3111MEAHVGINGE3121ANLDFLNIPL3131TIPEMRLPYT3141IITTPPLKDF
3151-32003151SLWEKTGLKE3161FLKTTKQSFD3171LSVKAQYKKN3181KHRHSITNPL3191AVLCEFISQS
3201-32503201IKSFDRHFEK3211NRNNALDFVT3221KSYNETKIKF3231DKYKAEKSHD3241ELPRTFQIPG
3251-33003251YTVPVVNVEV3261SPFTIEMSAF3271GYVFPKAVSM3281PSFSILGSDV3291RVPSYTLILP
3301-33503301SLELPVLHVP3311RNLKLSLPDF3321KELCTISHIF3331IPAMGNITYD3341FSFKSSVITL
3351-34003351NTNAELFNQS3361DIVAHLLSSS3371SSVIDALQYK3381LEGTTRLTRK3391RGLKLATALS
3401-34503401LSNKFVEGSH3411NSTVSLTTKN3421MEVSVATTTK3431AQIPILRMNF3441KQELNGNTKS
3451-35003451KPTVSSSMEF3461KYDFNSSMLY3471STAKGAVDHK3481LSLESLTSYF3491SIESSTKGDV
3501-35503501KGSVLSREYS3511GTIASEANTY3521LNSKSTRSSV3531KLQGTSKIDD3541IWNLEVKENF
3551-36003551AGEATLQRIY3561SLWEHSTKNH3571LQLEGLFFTN3581GEHTSKATLE3591LSPWQMSALV
3601-36503601QVHASQPSSF3611HDFPDLGQEV3621ALNANTKNQK3631IRWKNEVRIH3641SGSFQSQVEL
3651-37003651SNDQEKAHLD3661IAGSLEGHLR3671FLKNIILPVY3681DKSLWDFLKL3691DVTTSIGRRQ
3701-37503701HLRVSTAFVY3711TKNPNGYSFS3721IPVKVLADKF3731IIPGLKLNDL3741NSVLVMPTFH
3751-38003751VPFTDLQVPS3761CKLDFREIQI3771YKKLRTSSFA3781LNLPTLPEVK3791FPEVDVLTKY
3801-38503801SQPEDSLIPF3811FEITVPESQL3821TVSQFTLPKS3831VSDGIAALDL3841NAVANKIADF
3851-39003851ELPTIIVPEQ3861TIEIPSIKFS3871VPAGIVIPSF3881QALTARFEVD3891SPVYNATWSA
3901-39503901SLKNKADYVE3911TVLDSTCSST3921VQFLEYELNV3931LGTHKIEDGT3941LASKTKGTFA
3951-40003951HRDFSAEYEE3961DGKYEGLQEW3971EGKAHLNIKS3981PAFTDLHLRY3991QKDKKGISTS
4001-40504001AASPAVGTVG4011MDMDEDDDFS4021KWNFYYSPQS4031SPDKKLTIFK4041TELRVRESDE
4051-41004051ETQIKVNWEE4061EAASGLLTSL4071KDNVPKATGV4081LYDYVNKYHW4091EHTGLTLREV
4101-41504101SSKLRRNLQN4111NAEWVYQGAI4121RQIDDIDVRF4131QKAASGTTGT4141YQEWKDKAQN
4151-42004151LYQELLTQEG4161QASFQGLKDN4171VFDGLVRVTQ4181EFHMKVKHLI4191DSLIDFLNFP
4201-42504201RFQFPGKPGI4211YTREELCTMF4221IREVGTVLSQ4231VYSKVHNGSE4241ILFSYFQDLV
4251-43004251ITLPFELRKH4261KLIDVISMYR4271ELLKDLSKEA4281QEVFKAIQSL4291KTTEVLRNLQ
4301-43504301DLLQFIFQLI4311EDNIKQLKEM4321KFTYLINYIQ4331DEINTIFSDY4341IPYVFKLLKE
4351-44004351NLCLNLHKFN4361EFIQNELQEA4371SQELQQIHQY4381IMALREEYFD4391PSIVGWTVKY
4401-44504401YELEEKIVSL4411IKNLLVALKD4421FHSEYIVSAS4431NFTSQLSSQV4441EQFLHRNIQE
4451-45004451YLSILTDPDG4461KGKEKIAELS4471ATAQEIIKSQ4481AIATKKIISD4491YHQQFRYKLQ
4501-45504501DFSDQLSDYY4511EKFIAESKRL4521IDLSIQNYHT4531FLIYITELLK4541KLQSTTVMNP
4551-45634551YMKLAPGELT4561IIL
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
39 Apolipoprotein B - -
GPS-Palm: 0.88
Deep-Palm: 0.94
78 - - -
Deep-Palm: 0.91
88 - - -
Deep-Palm: 0.81
97 - - -
GPS-Palm: 0.77
Deep-Palm: 0.95
186 - - -
Deep-Palm: 0.83
212 - - -
GPS-Palm: 0.74
Deep-Palm: 0.89
245 -
HeLa (37611173)
-
GPS-Palm: 0.68
Deep-Palm: 0.75
261 - - -
GPS-Palm: 0.72
Deep-Palm: 0.62
385 - - -
Deep-Palm: 0.84
390 - - -
Deep-Palm: 0.64
478 - - -
Deep-Palm: 0.61
513 - - -
GPS-Palm: 0.83
Deep-Palm: 0.92
966 - - -
Deep-Palm: 0.41
976 - - -
GPS-Palm: 0.65
Deep-Palm: 0.38
1112 DBPTM SWISSPALM - - -
GPS-Palm: 0.87
Deep-Palm: 0.91
1422 - - -
GPS-Palm: 0.74
Deep-Palm: 0.46
1505 - - -
GPS-Palm: 0.92
Deep-Palm: 0.88
1662 - - -
GPS-Palm: 0.80
Deep-Palm: 0.97
2933 - - -
Deep-Palm: 0.36
3194 - - -
Deep-Palm: 0.69
3324 - - -
GPS-Palm: 0.75
Deep-Palm: 0.87
3761 - - -
Deep-Palm: 0.48
3917 - - -
Deep-Palm: 0.83
4217 - - -
GPS-Palm: 0.76
Deep-Palm: 0.83
4353 - - -
GPS-Palm: 0.91
Deep-Palm: 0.36
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
heart
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
186 C → F 0.001887 SNP Missense Mutation UCEC
219 R → C 0.001887 SNP Missense Mutation UCEC
233 R → C 0.002427 SNP Missense Mutation BLCA
297 R → C 0.001887 SNP Missense Mutation UCEC
437 R → C 0.001969 SNP Missense Mutation LGG
452 Y → C 0.001887 SNP Missense Mutation UCEC
724 G → C 0.002033 SNP Missense Mutation LUSC
804 R → C 0.002033 SNP Missense Mutation LUSC
924 F → C 0.001887 SNP Missense Mutation UCEC
993 Y → C 0.001969 SNP Missense Mutation HNSC
1128 R → C 0.001969 SNP Missense Mutation LGG
1169 Y → C 0.001887 SNP Missense Mutation UCEC
1319 P → Cfs*41 0.002288 INS Frame Shift Ins STAD
1332 S → C 0.002747 SNP Missense Mutation LIHC
1388 R → C 0.008565 SNP Missense Mutation SKCM
1451 G → C 0.002506 SNP Missense Mutation COAD
1505 C → F 0.001969 SNP Missense Mutation HNSC
1512 G → C 0.001764 SNP Missense Mutation LUAD
2031 S → C 0.001764 SNP Missense Mutation LUAD
2057 F → C 0.002288 SNP Missense Mutation STAD
2058 V → _K2059insIMRESKCQRFCFQQEFTIVAFV 0.001887 INS In Frame Ins UCEC
2073 F → C 0.001887 SNP Missense Mutation UCEC
2181 F → C 0.002506 SNP Missense Mutation COAD
2181 F → C 0.001887 SNP Missense Mutation UCEC
2219 R → C 0.002141 SNP Missense Mutation SKCM
2432 Y → C 0.001887 SNP Missense Mutation UCEC
2573 W → C 0.001764 SNP Missense Mutation LUAD
2617 F → C 0.003774 SNP Missense Mutation UCEC
2650 F → C 0.001887 SNP Missense Mutation UCEC
2673 I → _R2674insCPTIFQDILKSH 0.002545 INS In Frame Ins GBM
2834 Y → C 0.001887 SNP Missense Mutation UCEC
2902 S → C 0.002747 SNP Missense Mutation LIHC
2980 S → C 0.005435 SNP Missense Mutation ESCA
3006 G → C 0.002506 SNP Missense Mutation COAD
3058 V → _R3059insLC 0.001887 INS In Frame Ins UCEC
3059 R → C 0.006424 SNP Missense Mutation SKCM
3136 R → C 0.002506 SNP Missense Mutation COAD
3136 R → C 0.002141 SNP Missense Mutation SKCM
3194 C → F 0.001969 SNP Missense Mutation HNSC
3233 Y → C 0.001969 SNP Missense Mutation HNSC
3251 Y → C 0.001887 SNP Missense Mutation UCEC
3454 V → Cfs*8 0.002747 INS Frame Shift Ins LIHC
3471 S → C 0.002294 SNP Missense Mutation OV
3495 S → C 0.002427 SNP Missense Mutation BLCA
3502 G → C 0.002976 SNP Missense Mutation KIRC
3558 R → C 0.007299 SNP Missense Mutation READ
3703 R → C 0.002141 SNP Missense Mutation SKCM
3958 Y → C 0.003559 SNP Missense Mutation KIRP
4130 F → C 0.002506 SNP Missense Mutation COAD
4322 F → C 0.002506 SNP Missense Mutation COAD
4345 F → C 0.003774 SNP Missense Mutation UCEC
4385 R → C 0.001969 SNP Missense Mutation LGG
4513 F → C 0.001887 SNP Missense Mutation UCEC