Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P04264 | KRT1 | Keratin, type II cytoskeletal 1 … | Homo sapiens (Human) | 644 aa |
Protein Details: P04264 (KRT1)
Protein Information
| Accession | P04264 |
|---|---|
| Protein Names | Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1) |
| Gene Symbol | KRT1 |
| Organism | Homo sapiens (Human) |
| Length | 644 aa |
| Isoforms | No isoforms |
| Related PMIDs | 25914232 31382980 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSRQFSSRSG11YRSGGGFSSG21SAGIINYQRR31TTSSSTRRSG41GGGGRFSSCG
51-10051GGGGSFGAGG61GFGSRSLVNL71GGSKSISISV81ARGGGRGSGF91GGGYGGGGFG
101-150101GGGFGGGGFG111GGGIGGGGFG121GFGSGGGGFG131GGGFGGGGYG141GGYGPVCPPG
151-200151GIQEVTINQS161LLQPLNVEID171PEIQKVKSRE181REQIKSLNNQ191FASFIDKVRF
201-250201LEQQNQVLQT211KWELLQQVDT221STRTHNLEPY231FESFINNLRR241RVDQLKSDQS
251-300251RLDSELKNMQ261DMVEDYRNKY271EDEINKRTNA281ENEFVTIKKD291VDGAYMTKVD
301-350301LQAKLDNLQQ311EIDFLTALYQ321AELSQMQTQI331SETNVILSMD341NNRSLDLDSI
351-400351IAEVKAQYED361IAQKSKAEAE371SLYQSKYEEL381QITAGRHGDS391VRNSKIEISE
401-450401LNRVIQRLRS411EIDNVKKQIS421NLQQSISDAE431QRGENALKDA441KNKLNDLEDA
451-500451LQQAKEDLAR461LLRDYQELMN471TKLALDLEIA481TYRTLLEGEE491SRMSGECAPN
501-550501VSVSVSTSHT511TISGGGSRGG521GGGGYGSGGS531SYGSGGGSYG541SGGGGGGGRG
551-600551SYGSGGSSYG561SGGGSYGSGG571GGGGHGSYGS581GSSSGGYRGG591SGGGGGGSSG
601-644601GRGSGGGSSG611GSIGGRGSSS621GGVKSSGGSS631SVKFVSTTYS641GVTR
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 49 | - | - |
Liver
(37925639)
Brain
(35358180)
Macrophage Raw 264.7
(29217618)
Brain
(31311849)
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.92
|
|
| 147 | - | - | - |
Deep-Palm: 0.69
|
|
| 497 | - | - |
Liver
(34884899)
Liver
(37925639)
Brain
(35358180)
Brain
(31311849)
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.88
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
PC3
Specificity: 0.308
4/4 (100.0%)
3
CEM 174 cell
Specificity: 0.231
3/3 (100.0%)
1
U937 cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.308
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.077
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 16 | G → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 20 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 29 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 29 | R → C | 0.005013 | SNP | Missense Mutation | COAD |
| 29 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 89 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 144 | G → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 230 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 324 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 343 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 403 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 432 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 463 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 605 | G → C | 0.001969 | SNP | Missense Mutation | HNSC |