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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P04350 TUBB4A Tubulin beta-4A chain (Tubulin 5 … Homo sapiens (Human) 444 aa

Protein Details: P04350 (TUBB4A)

Protein Information
AccessionP04350
Protein NamesTubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain)
Gene SymbolTUBB4A
OrganismHomo sapiens (Human)
Length444 aa
IsoformsNo isoforms
Related PMIDs 29733200 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MREIVHLQAG11QCGNQIGAKF21WEVISDEHGI31DPTGTYHGDS41DLQLERINVY
51-10051YNEATGGNYV61PRAVLVDLEP71GTMDSVRSGP81FGQIFRPDNF91VFGQSGAGNN
101-150101WAKGHYTEGA111ELVDAVLDVV121RKEAESCDCL131QGFQLTHSLG141GGTGSGMGTL
151-200151LISKIREEFP161DRIMNTFSVV171PSPKVSDTVV181EPYNATLSVH191QLVENTDETY
201-250201CIDNEALYDI211CFRTLKLTTP221TYGDLNHLVS231ATMSGVTTCL241RFPGQLNADL
251-300251RKLAVNMVPF261PRLHFFMPGF271APLTSRGSQQ281YRALTVPELT291QQMFDAKNMM
301-350301AACDPRHGRY311LTVAAVFRGR321MSMKEVDEQM331LSVQSKNSSY341FVEWIPNNVK
351-400351TAVCDIPPRG361LKMAATFIGN371STAIQELFKR381ISEQFTAMFR391RKAFLHWYTG
401-444401EGMDEMEFTE411AESNMNDLVS421EYQQYQDATA431EEGEFEEEAE441EEVA
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
12 Tubulin/FtsZ, GTPase domain superfamily OS01G0282866 PROTEIN - -
GPS-Palm: 0.65
Deep-Palm: 0.06
127 - - -
GPS-Palm: 0.68
Deep-Palm: 0.88
129 - - -
Deep-Palm: 0.92
201 - - -
Deep-Palm: 0.13
211 - - -
GPS-Palm: 0.79
Deep-Palm: 0.16
239 - -
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.90
Deep-Palm: 0.97
303 - -
Unknown (32651440)
cerebral cortex (36430497)
GPS-Palm: 0.94
Deep-Palm: 0.68
354 SWISSPALM DBPTM CYSMODDB Tubulin C-terminal domain -
cerebral cortex (36430497)
GPS-Palm: 0.92
Deep-Palm: 0.74
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
cerebral cortex
Specificity: 0.333
4/4 (100.0%)
3
LNCaP
Specificity: 0.250
3/3 (100.0%)
1
HAP1 cell
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.333
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
77 R → C 0.002141 SNP Missense Mutation SKCM
127 C → C 0.001887 SNP Silent UCEC
156 R → C 0.002020 SNP Missense Mutation PRAD
162 R → C 0.002506 SNP Missense Mutation COAD
183 Y → C 0.002033 SNP Missense Mutation LUSC
213 R → C 0.001969 SNP Missense Mutation HNSC
251 R → C 0.002506 SNP Missense Mutation COAD
251 R → C 0.001969 SNP Missense Mutation LGG
262 R → C 0.002288 SNP Missense Mutation STAD
303 C → C 0.002545 SNP Silent GBM
309 R → C 0.002545 SNP Missense Mutation GBM
309 R → C 0.001887 SNP Missense Mutation UCEC
354 C → C 0.002506 SNP Silent COAD
354 C → C 0.003774 SNP Silent UCEC
380 R → C 0.001887 SNP Missense Mutation UCEC
391 R → C 0.002020 SNP Missense Mutation PRAD
391 R → C 0.002294 SNP Missense Mutation OV