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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
P04350 TUBB4A; TUBB4; TUBB5 Tubulin beta-4A chain (Tubulin 5 … Homo sapiens (Human) 444 aa

Protein Details: P04350 (TUBB4A)

Protein Information
Accession P04350
Protein Names Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain)
Gene Symbol TUBB4A; TUBB4; TUBB5
Organism Homo sapiens (Human)
Length 444 aa
Isoforms No isoforms
Related PMIDs 29733200 31251020 36430497 37611173
Database Sources CysModDB dbPTM SwissPalm
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.778
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
35
LNCaP cells
Specificity: 0.778
35/46 (76.1%)
6
HAP1 cells
Specificity: 0.133
6/10 (60.0%)
4
Cerebral cortex
Specificity: 0.089
4/4 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MREIVHLQAG11QCGNQIGAKF21WEVISDEHGI31DPTGTYHGDS41DLQLERINVY
51-10051YNEATGGNYV61PRAVLVDLEP71GTMDSVRSGP81FGQIFRPDNF91VFGQSGAGNN
101-150101WAKGHYTEGA111ELVDAVLDVV121RKEAESCDCL131QGFQLTHSLG141GGTGSGMGTL
151-200151LISKIREEFP161DRIMNTFSVV171PSPKVSDTVV181EPYNATLSVH191QLVENTDETY
201-250201CIDNEALYDI211CFRTLKLTTP221TYGDLNHLVS231ATMSGVTTCL241RFPGQLNADL
251-300251RKLAVNMVPF261PRLHFFMPGF271APLTSRGSQQ281YRALTVPELT291QQMFDAKNMM
301-350301AACDPRHGRY311LTVAAVFRGR321MSMKEVDEQM331LSVQSKNSSY341FVEWIPNNVK
351-400351TAVCDIPPRG361LKMAATFIGN371STAIQELFKR381ISEQFTAMFR391RKAFLHWYTG
401-444401EGMDEMEFTE411AESNMNDLVS421EYQQYQDATA431EEGEFEEEAE441EEVA
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
12 Prediction (Low) - -
127 Prediction (Low) - -
211 Prediction (Medium) - -
239 Prediction (High) - -
303 Prediction (High) - -
354 Experimental CYSMODDB SWISSPALM DBPTM Prediction (High) Tubulin C-terminal domain 37611173
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
77 R → C 0.002141 SNP Missense Mutation SKCM
127 C → C 0.001887 SNP Silent UCEC
156 R → C 0.002020 SNP Missense Mutation PRAD
162 R → C 0.002506 SNP Missense Mutation COAD
183 Y → C 0.002033 SNP Missense Mutation LUSC
213 R → C 0.001969 SNP Missense Mutation HNSC
251 R → C 0.002506 SNP Missense Mutation COAD
251 R → C 0.001969 SNP Missense Mutation LGG
262 R → C 0.002288 SNP Missense Mutation STAD
303 C → C 0.002545 SNP Silent GBM
309 R → C 0.002545 SNP Missense Mutation GBM
309 R → C 0.001887 SNP Missense Mutation UCEC
354 C → C 0.002506 SNP Silent COAD
354 C → C 0.003774 SNP Silent UCEC
380 R → C 0.001887 SNP Missense Mutation UCEC
391 R → C 0.002020 SNP Missense Mutation PRAD
391 R → C 0.002294 SNP Missense Mutation OV