Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P04843 | RPN1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein … | Homo sapiens (Human) | 607 aa |
Protein Details: P04843 (RPN1)
Protein Information
| Accession | P04843 |
|---|---|
| Protein Names | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) |
| Gene Symbol | RPN1 |
| Organism | Homo sapiens (Human) |
| Length | 607 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29733200 31251020 32944167 33636221 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEAPAAGLFL11LLLLGTWAPA21PGSASSEAPP31LINEDVKRTV41DLSSHLAKVT
51-10051AEVVLAHLGG61GSTSRATSFL71LALEPELEAR81LAHLGVQVKG91EDEEENNLEV
101-150101RETKIKGKSG111RFFTVKLPVA121LDPGAKISVI131VETVYTHVLH141PYPTQITQSE
151-200151KQFVVFEGNH161YFYSPYPTKT171QTMRVKLASR181NVESYTKLGN191PTRSEDLLDY
201-250201GPFRDVPAYS211QDTFKVHYEN221NSPFLTITSM231TRVIEVSHWG241NIAVEENVDL
251-300251KHTGAVLKGP261FSRYDYQRQP271DSGISSIRSF281KTILPAAAQD291VYYRDEIGNV
301-350301STSHLLILDD311SVEMEIRPRF321PLFGGWKTHY331IVGYNLPSYE341YLYNLGDQYA
351-400351LKMRFVDHVF361DEQVIDSLTV371KIILPEGAKN381IEIDSPYEIS391RAPDELHYTY
401-450401LDTFGRPVIV411AYKKNLVEQH421IQDIVVHYTF431NKVLMLQEPL441LVVAAFYILF
451-500451FTVIIYVRLD461FSITKDPAAE471ARMKVACITE481QVLTLVNKRI491GLYRHFDETV
501-550501NRYKQSRDIS511TLNSGKKSLE521TEHKALTSEI531ALLQSRLKTE541GSDLCDRVSE
551-600551MQKLDAQVKE561LVLKSAVEAE571RLVAGKLKKD581TYIENEKLIS591GKRQELVTKI
601-607601DHILDAL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 477 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.85
Deep-Palm: 0.97
|
| 545 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.79
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.273
3
LNCaP
Specificity: 0.273
3/3 (100.0%)
3
PC3
Specificity: 0.273
3/3 (100.0%)
2
HAP1 cell
Specificity: 0.182
2/2 (100.0%)
2
293T cell
Specificity: 0.182
2/2 (100.0%)
1
heart
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 101 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 263 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 406 | R → C | 0.001969 | SNP | Missense Mutation | LGG |