Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| P07195 | LDHB | L-lactate dehydrogenase B chain (LDH-B) … | Homo sapiens (Human) | 334 aa |
Protein Details: P07195 (LDHB)
Protein Information
| Accession | P07195 |
|---|---|
| Protein Names | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) |
| Gene Symbol | LDHB |
| Organism | Homo sapiens (Human) |
| Length | 334 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 29733200 31251020 31382980 32944167 33636221 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MATLKEKLIA11PVAEEEATVP21NNKITVVGVG31QVGMACAISI41LGKSLADELA
51-10051LVDVLEDKLK61GEMMDLQHGS71LFLQTPKIVA81DKDYSVTANS91KIVVVTAGVR
101-150101QQEGESRLNL111VQRNVNVFKF121IIPQIVKYSP131DCIIIVVSNP141VDILTYVTWK
151-200151LSGLPKHRVI161GSGCNLDSAR171FRYLMAEKLG181IHPSSCHGWI191LGEHGDSSVA
201-250201VWSGVNVAGV211SLQELNPEMG221TDNDSENWKE231VHKMVVESAY241EVIKLKGYTN
251-300251WAIGLSVADL261IESMLKNLSR271IHPVSTMVKG281MYGIENEVFL291SLPCILNARG
301-334301LTSVINQKLK311DDEVAQLKKS321ADTLWDIQKD331LKDL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 36 | L-lactate/malate dehydrogenase L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) NAD(P)-binding domain superfamily Lactate/malate dehydrogenase, N-terminal | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.98
|
|
| 132 | - | - | - |
Deep-Palm: 0.76
|
|
| 164 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.95
Deep-Palm: 0.98
|
| 186 | - | - | - |
Deep-Palm: 0.77
|
|
| 294 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.89
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.250
4
PC3
Specificity: 0.200
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.200
4/4 (100.0%)
2
LNCaP
Specificity: 0.100
2/2 (100.0%)
2
HAP1 cell
Specificity: 0.100
2/2 (100.0%)
1
U937 cell
Specificity: 0.050
1/1 (100.0%)
1
EC cell
Specificity: 0.050
1/1 (100.0%)
1
293T cell
Specificity: 0.050
1/1 (100.0%)
1
heart
Specificity: 0.050
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.200
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 100 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 158 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 204 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| ? | ? → ? | 0.002506 | SNP | Nonstop Mutation | COAD |